Nintabid 100mg

NINTABID 100MG

NINTABID 100MG is a brand-name medication containing the active ingredient Nintedanib. It is manufactured by J.B. CHEMICALS.

• Composition: Each capsule of NINTABID 100MG contains Nintedanib 100mg. Nintedanib is classified as a tyrosine kinase inhibitor, which works by blocking enzymes involved in fibrosis (scarring) and tumor growth.

• Uses: NINTABID 100MG is primarily prescribed for adults to manage various serious lung conditions and certain types of lung cancer:

  • Idiopathic Pulmonary Fibrosis (IPF): A chronic lung disease causing scarring in the lungs.
  • Chronic Fibrosing Interstitial Lung Diseases (ILDs) with a progressive phenotype.
  • Systemic Sclerosis-Associated Interstitial Lung Disease (SSc-ILD).
  • Non-Small Cell Lung Cancer (NSCLC): Specifically, locally advanced, metastatic, or recurrent adenocarcinoma, typically in combination with other chemotherapy after first-line treatment.

• Dosage and Administration: The typical recommended adult dosage for Nintedanib is 150 mg taken orally twice daily, approximately 12 hours apart. However, NINTABID is available in 100mg capsules, and your doctor will determine the appropriate dose and regimen for your specific condition. Capsules should be swallowed whole with food and a full glass of water, without crushing, chewing, or breaking them. If a dose is missed, skip it and resume the regular dosing schedule; do not take a double dose. This medication is recommended only for adults.

• Side Effects:

  • Common: Diarrhea, nausea, vomiting, abdominal pain, decreased appetite, headache, weight loss, high blood pressure, and abnormal liver function tests.
  • Serious: May include severe or persistent gastrointestinal issues (nausea, vomiting, diarrhea, abdominal pain), liver problems (e.g., jaundice, dark urine), increased risk of bleeding, blood clots, heart attack, stroke, or stomach/bowel perforation.

• Precautions: Regular monitoring of liver function through blood tests is crucial, especially during the initial months of treatment. Inform your doctor about all other medications, including over-the-counter drugs, herbal supplements (like St. John's Wort), and blood thinners, to avoid potential interactions. NINTABID 100MG is not recommended during pregnancy due to potential harm to the fetus; effective contraception is advised during treatment and for at least three months afterward. Patients with a history of bleeding disorders, liver, or heart problems should inform their doctor. Smoking and alcohol consumption should be avoided.

• Storage: Store NINTABID 100MG capsules in a closed container at room temperature, away from excessive heat, moisture, and direct light. Do not freeze. Keep this medication out of the reach of children.

NINTABID 100MG (Nintedanib 100mg) is a medication manufactured by J.B. Chemicals & Pharmaceuticals Ltd. It is a tyrosine kinase inhibitor primarily used to manage certain lung conditions and specific types of lung cancer.

What is NINTABID 100MG used for?

NINTABID 100MG is used to treat Idiopathic Pulmonary Fibrosis (IPF), which is a chronic lung disease that causes scarring in the lungs. It is also prescribed for chronic fibrosing interstitial lung diseases with a progressive phenotype, systemic sclerosis-associated interstitial lung disease (SSc-ILD), and advanced non-small cell lung cancer (NSCLC) of adenocarcinoma type, particularly after first-line chemotherapy has been unsuccessful.

How does NINTABID 100MG work?

NINTABID 100MG contains Nintedanib, which is an antineoplastic and antiangiogenic agent, functioning as a tyrosine kinase inhibitor. It works by blocking multiple receptor tyrosine kinases (such as PDGFR, FGFR, VEGFR) and non-receptor tyrosine kinases, which are involved in processes that lead to fibrosis (scarring) in the lungs and tumor growth. By inhibiting these enzymes, it helps slow down the progression of lung fibrosis and the multiplication of abnormal cells in certain cancers.

What is the usual dosage for NINTABID 100MG?

For Idiopathic Pulmonary Fibrosis (IPF) and Systemic Sclerosis-associated Interstitial Lung Disease (SSc-ILD), the recommended dosage is typically 100mg taken orally twice a day with food. For non-small cell lung cancer, when used in combination with docetaxel, the recommended dose may be 200mg twice daily on days 2 to 21 of a 21-day docetaxel cycle, but not on the same day as docetaxel administration. Your doctor will determine the exact dose and duration of treatment based on your specific condition and how you respond to the medication.

What are the possible side effects of NINTABID 100MG?

Common side effects include diarrhea, nausea, vomiting, abdominal pain, decreased appetite, headache, weight loss, and elevated liver enzymes. Other possible side effects can include hypertension, skin ulcer, bleeding events, bronchitis, hypothyroidism, and gastrointestinal perforation. If you experience severe or persistent side effects, especially severe diarrhea, unusual bleeding, yellowing of skin or eyes, or dark urine, contact your doctor immediately.

Is NINTABID 100MG safe during pregnancy or breastfeeding?

NINTABID 100MG is not recommended during pregnancy due to definite evidence of risk to the developing baby, as it can cause embryo-fetal toxicity. Women of childbearing potential should use effective contraception during treatment and for at least one month after stopping the medication. It is also not recommended for use during breastfeeding, as the drug and its metabolites may pass into breast milk and could harm the infant.

Can NINTABID 100MG be taken with other medications?

NINTABID 100MG can interact with other medications. For example, medicines like ketoconazole and itraconazole may increase its levels in the blood, potentially leading to more side effects. Anticonvulsants such as carbamazepine and phenytoin may reduce its effectiveness. Taking it with blood thinners (anticoagulants like warfarin or heparin) or NSAIDs can increase the risk of bleeding. It is important to inform your doctor about all medications, supplements, and herbal products you are taking to avoid potential interactions.

What precautions should be taken with NINTABID 100MG?

You should take NINTABID 100MG with food, and swallow the capsule whole without chewing or crushing it. Regular monitoring of liver function and blood pressure is essential during treatment. Exercise caution when driving or operating machinery, as the medication can cause side effects like dizziness or tiredness. Avoid consuming grapes and grapefruit juice while on this medication. Alcohol intake should also be discussed with your doctor due to potential increased risk of liver problems. Inform your doctor if you have liver, kidney, or bleeding problems, or a history of heart issues.

What happens if a dose is missed?

If you miss a dose of NINTABID 100MG, take it as soon as you remember, provided it is within 6 hours of the scheduled time. If more than 6 hours have passed, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a forgotten one.

How should NINTABID 100MG be stored?

NINTABID 100MG should be stored at room temperature, generally below 30°C, away from moisture and heat. It should be kept out of the reach and sight of children and pets. Dispose of expired medication immediately and safely, preferably through a medication take-back program.