Pirox Gel 30 Gm

Pirox Gel 30 GM by Cipla Ltd.

Pirox Gel 30 GM is a topical non-steroidal anti-inflammatory drug (NSAID) designed for localized relief of pain and inflammation. It is manufactured by Cipla Ltd. (Generic Division).

• Name:

  • Common Name: Pirox Gel
  • Brand Name: Pirox Gel (Cipla Ltd.)

• Composition:

  • Active Ingredient: Piroxicam 0.5% w/w
  • Other Ingredients: Benzyl alcohol, carbopol 980, di-isopropanolamine, ethanol, hydroxy-ethyl cellulose, propylene glycol, and purified water. Propylene glycol and benzyl alcohol are known excipients that may cause irritation or allergic reactions.

• Uses: Pirox Gel is primarily used for the symptomatic treatment of pain, inflammation, and stiffness associated with various musculoskeletal conditions. It works by inhibiting the production of prostaglandins, which are chemicals in the body responsible for pain and swelling.

  • Medical Conditions:
    • Osteoarthritis (especially superficial joints like the knee)
    • Rheumatoid arthritis
    • Ankylosing spondylitis
    • Acute musculoskeletal injuries (e.g., bursitis, periarthritis, tendinitis, tenosynovitis)
    • Post-traumatic conditions (e.g., sprains, strains, bruises)
    • Lower back pain
    • Acute gout

• Dosage and Administration:

  • Pirox Gel is for external use only.
  • Adults: Apply approximately 1g of gel (about 3 cm or 1 1/4 inches) to the affected area.
  • Frequency: Typically, apply 2 to 4 times daily, or as directed by a healthcare professional.
  • Gently massage the gel into the skin until no residual material remains.
  • Wash hands thoroughly before and after application, unless the treatment area is on the hands.
  • Do not apply occlusive dressings (e.g., bandages) over the treated area.
  • Do not use for more than 4 weeks without consulting a doctor.
  • Do not exceed 25g of the gel in one day.
  • Not recommended for children under 12 or 15 years of age due to lack of established dosage and experience.

• Side Effects:

  • Common: Local skin reactions such as irritation, redness (erythema), itching, rash, contact dermatitis, eczema, skin pigmentation, mild discoloration, soreness, pain, numbness, or tingling at the application site. Increased sensitivity to sunlight (photosensitivity) may also occur.
  • Serious (rare but possible): Allergic reactions including hives, swelling of the face or tongue, difficulty breathing, or breathlessness. Severe cutaneous adverse reactions (SCARs) like Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) have been reported with systemic piroxicam and cannot be entirely ruled out with topical use. Stop use immediately if blistering, bruising, or ulcers appear on the skin or mucous membranes (mouth, nose, throat, genitals).
  • Systemic Effects (less common with topical application): Stomach pain, indigestion, nausea, vomiting, diarrhea, constipation, headaches, dizziness, lightheadedness, elevated blood pressure, increased risk of bleeding, impaired kidney function, or liver damage.

• Precautions:

  • Avoid contact with eyes, nose, mouth, and other mucous membranes. If accidental contact occurs, rinse thoroughly with plenty of clean water.
  • Do not apply the gel to broken, inflamed, diseased, infected, or open skin/wounds.
  • Avoid exposing treated areas to direct sunlight or sunlamps as the gel can increase skin sensitivity.
  • Contraindicated in individuals with a history of hypersensitivity to piroxicam, aspirin, or other NSAIDs, especially if these caused asthma, rhinitis, urticaria, nasal polyps, or angioneurotic edema.
  • Pregnant or breastfeeding women should avoid using Pirox Gel.
  • Use with caution in elderly patients and those with a history of serious allergic skin reactions, or with existing liver or kidney problems.
  • Inform your doctor or pharmacist about any other medications you are taking, especially aspirin, other painkillers, or anticoagulants, as interactions may occur.
  • Fabrics (clothing, bedding, dressings) that have been in contact with this product burn more easily and pose a serious fire hazard.

• Storage:

  • Store below 30°C.
  • Keep out of sight and reach of children.
  • Store in its original packaging in a cool, dry place, away from direct heat and light.
  • Do not store in the bathroom or near a sink.
  • Always replace the cap tightly after use.

PIROX GEL 30 GM by CIPLA LTD. (GENERIC DIVISION) is a topical medication containing Piroxicam, a non-steroidal anti-inflammatory drug (NSAID), primarily used to relieve pain and inflammation in various musculoskeletal conditions.

What is PIROX GEL used for?

PIROX GEL is primarily used for the short-term relief of pain, inflammation, and stiffness associated with conditions affecting joints and muscles. This includes conditions such as osteoarthritis, rheumatoid arthritis, minor injuries like sprains and bruises, tendinitis, tenosynovitis, periarthritis, and low back pain.

How does PIROX GEL work?

PIROX GEL contains Piroxicam, which belongs to the class of NSAIDs. It works by inhibiting enzymes responsible for producing prostaglandins, which are natural chemicals in the body that cause pain, swelling, and inflammation at the site of injury or disease. By blocking these chemical messengers, Piroxicam helps to reduce discomfort and improve movement in the affected area.

What is the usual dosage of PIROX GEL?

PIROX GEL is for external use only. A thin layer of the gel should be applied to the affected area and gently massaged into the skin. The specific frequency and duration of application should be as advised by your doctor. It is recommended to wash your hands thoroughly before and after applying the gel, unless your hands are the area being treated.

What are the possible side effects of PIROX GEL?

Common side effects of PIROX GEL include localized skin reactions such as irritation, redness (erythema), itching (pruritus), skin rash, contact dermatitis, or eczema at the application site. In rare cases, more severe reactions like increased sensitivity to sunlight, blistering, or mouth sores may occur. If severe reactions or worsening of symptoms are experienced, it is important to contact your doctor immediately.

Is PIROX GEL safe during pregnancy or breastfeeding?

The use of PIROX GEL is generally not recommended during pregnancy, especially during the later stages, as studies in animals have shown harmful effects on the developing baby. Similarly, it is probably unsafe to use during breastfeeding, as limited human data suggests the drug may pass into breast milk and potentially harm the baby. Always consult your doctor before using this medicine if you are pregnant, planning to become pregnant, or breastfeeding.

Can PIROX GEL be taken with other medications?

Due to its topical application, PIROX GEL is less likely to interact with oral medications. However, it may interact with other topical medications. For instance, topical anti-acne medicines containing benzoyl peroxide or salicylic acid, and topical corticosteroids, may have altered effectiveness or increased risk of skin irritation when used concurrently. It is advisable to inform your doctor about all medicines you are currently using, including prescription, over-the-counter, and herbal products, to avoid potential interactions.

What precautions should be taken while using PIROX GEL?

Avoid applying PIROX GEL to broken, wounded, diseased, infected, or irritated skin, as this may increase absorption and potential side effects. Do not let the gel come into contact with your eyes, lips, mouth, nose, or genital/anal areas; if accidental contact occurs, rinse thoroughly with clean water. Do not cover the treated area with occlusive bandages or dressings unless specifically instructed by your doctor, as this may increase the risk of side effects. Use caution if you have pre-existing skin conditions like eczema or psoriasis, or if you have a history of severe allergic reactions to NSAIDs. Avoid prolonged exposure to sunlight on the treated area, as the gel may increase sensitivity to the sun.

What happens if a dose of PIROX GEL is missed?

If you miss a dose of PIROX GEL, apply it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular application schedule. Do not apply a double dose to compensate for the missed one.

How should PIROX GEL be stored?

PIROX GEL should be stored in a cool, dry place, away from direct sunlight. Keep it out of the reach and sight of children and pets. The gel should be stored at temperatures between 10ºC and 25ºC or below 30ºC, and should not be frozen.