Dapaturn Gm Forte 1 Tab

DAPATURN GM FORTE 1 TAB by LUPIN LTD: Detailed Product Description

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Name

• Common Name: Dapaturn GM Forte 1 Tablet
• Manufacturer: Lupin Ltd.

Composition

Dapaturn GM Forte 1 Tablet is a fixed-dose combination medication containing three active ingredients:

• Dapagliflozin: 10 mg (Sodium-glucose cotransporter-2 (SGLT2) inhibitor)
• Metformin: 1000 mg (Biguanide)
• Glimepiride: 1 mg (Sulfonylurea)

Uses

Dapaturn GM Forte 1 Tablet is an antidiabetic medicine primarily used for the management of Type 2 Diabetes Mellitus in adults. It is prescribed when diet and exercise alone, or dual therapy, are insufficient to control blood sugar levels. Its actions include:

• Controlling high blood sugar levels.
• Improving glycemic control (long-term blood sugar control).
• Enhancing insulin sensitivity.
• Reducing glucose production by the liver.
• Increasing the elimination of excess glucose through urine.
• Stimulating natural insulin release from the pancreas.
• Reducing the risk of diabetes-related complications such as kidney damage, nerve issues, and heart disease.

Dosage and Administration

• Take Dapaturn GM Forte 1 Tablet orally as prescribed by your doctor.
• It is usually taken once daily with or after the first meal of the day to minimize stomach upset and reduce the risk of low blood sugar.
• Swallow the tablet whole with water; do not crush, break, or chew it.
• Adhere strictly to the prescribed dosage and do not stop taking the medicine without consulting your doctor.
• This medication is part of a treatment program that should include a healthy diet, regular exercise, and weight reduction as advised by your doctor.

Side Effects

Common Side Effects:

• Vomiting, nausea, abdominal pain.
• Headache, dizziness, asthenia.
• Low blood sugar (hypoglycemia), sweating, shakiness, hunger, confusion.
• Diarrhea, constipation.
• Urinary tract infections.
• Female genital infections.
• Nasopharyngitis (common cold).
• Sore throat, muscle pain, back pain.
• Increased urination.

Serious Side Effects (Seek immediate medical help if these occur):

• Lactic acidosis (a rare but life-threatening buildup of lactic acid in the blood).
• Severe urinary tract infections.
• Severe low blood sugar.
• Allergic reactions (e.g., rash, hives, itching, swelling of face, lips, tongue, or throat).

Precautions

• Contraindications: Do not use if allergic to dapagliflozin, glimepiride, metformin, or any other component. It is also contraindicated in individuals with severe kidney disease (eGFR below 30 ml/min/1.73 m²), metabolic acidosis, severe liver disease, Type 1 diabetes, bladder cancer, severe heart failure, lactic acidosis, severe low blood pressure, severe dehydration, diabetic ketoacidosis, or severe infection.
• Alcohol: Avoid excessive alcohol consumption as it increases the risk of hypoglycemia and lactic acidosis.
• Pregnancy & Breastfeeding: Not recommended during pregnancy (especially 2nd and 3rd trimesters) or breastfeeding. Consult your doctor if you are pregnant, planning pregnancy, or breastfeeding.
• Kidney & Liver Function: Use with caution in patients with kidney or liver problems. Regular monitoring of kidney function is recommended, and dosage adjustments may be necessary.
• Children: Not recommended for use in children below 18 years as safety and effectiveness have not been established.
• Driving: Exercise caution while driving or operating machinery, as the medicine may cause low blood sugar (hypoglycemia) or dizziness, affecting concentration.
• Drug Interactions: Inform your doctor about all medicines, supplements, or herbal products you are currently taking to avoid potential interactions. Specific interactions include insulin secretagogues, protein-bound medicines (e.g., salicylates, sulfonamides), carbonic anhydrase inhibitors, diuretics, and iodinated contrast agents.
• Hydration: Stay well-hydrated, as this medicine may increase urination and the risk of dehydration.

Storage

• Store Dapaturn GM Forte 1 Tablet in a cool and dry place, away from direct sunlight.
• Maintain storage temperatures between 10ºC to 25ºC or below 30ºC.
• Protect from moisture and light.
• Keep out of the sight and reach of children.

What is DAPATURN GM FORTE 1 TAB used for?

DAPATURN GM FORTE 1 TAB is an anti-diabetic medicine used in adults to treat Type 2 Diabetes Mellitus. It helps control high blood sugar levels, especially when diet and exercise alone or treatment with a single or dual therapy are not sufficient. It also aims to reduce the risk of diabetes-related complications, such as kidney damage, nerve issues, heart problems, and eye damage, and to improve long-term blood sugar control (HbA1c levels).

How does DAPATURN GM FORTE 1 TAB work?

This medicine is a combination of three active ingredients: Dapagliflozin, Metformin, and Glimepiride, each working through a different mechanism to lower blood sugar.

• Dapagliflozin (an SGLT2 inhibitor) helps remove excess sugar from the body by increasing its excretion through urine.
• Metformin (a biguanide) reduces the production of sugar by the liver, delays the absorption of sugar from the intestines, and enhances the body's sensitivity to insulin.
• Glimepiride (a sulfonylurea) stimulates the beta cells in the pancreas to produce and release more insulin, which helps remove sugar from the blood.

What is the usual dosage for DAPATURN GM FORTE 1 TAB?

The dosage of DAPATURN GM FORTE 1 TAB should be strictly as prescribed by your doctor. It is typically taken with meals to help reduce the risk of stomach upset. The exact dose may vary based on your individual response to the treatment and your kidney function.

What are the possible side effects of DAPATURN GM FORTE 1 TAB?

Common side effects may include low blood sugar (hypoglycemia), nausea, vomiting, abdominal pain, headache, diarrhea, female genital infections, urinary tract infections, sore throat, muscle pain, dizziness, back pain, increased urination, nasopharyngitis, loss of appetite, metallic taste, constipation, and weight gain. If any of these side effects persist or worsen, you should consult your doctor. Serious but rare side effects can include lactic acidosis, a dangerous buildup of acid in the blood, and severe urinary tract infections.

Is DAPATURN GM FORTE 1 TAB safe during pregnancy or breastfeeding?

Pregnancy: DAPATURN GM FORTE 1 TAB is generally not recommended during pregnancy. Limited human studies exist, and animal studies have shown potential harmful effects on the developing baby. Your doctor will weigh the benefits and potential risks before prescribing it. Breastfeeding: This medicine is generally not recommended for breastfeeding mothers. Information regarding its use during breastfeeding is often unavailable, or data suggests a potential for toxicity to the baby. Consult your doctor if you are breastfeeding.

Can DAPATURN GM FORTE 1 TAB be taken with other medications?

DAPATURN GM FORTE 1 TAB can interact with various medications. It's crucial to inform your doctor about all prescription drugs, over-the-counter medicines, supplements, and herbal products you are currently taking or plan to take. Potential interactions include:

• Other anti-diabetic medications (e.g., insulin secretagogues like glibenclamide, gliclazide, or insulin itself) which can increase the risk of low blood sugar.
• Certain protein-bound medicines (e.g., salicylates, sulfonamides, chloramphenicol).
• Carbonic anhydrase inhibitors (e.g., acetazolamide, topiramate) which can increase the risk of lactic acidosis.
• Diuretics (water pills, e.g., furosemide, hydrochlorothiazide) which may increase the risk of dehydration and low blood pressure.
• Certain antibiotics, antifungals, calcium channel blockers, antacids, HIV/AIDS drugs, heart medicines, anticancer drugs, and anticonvulsants.
• Some pain management medications (e.g., aspirin, ibuprofen, certain corticosteroids).

What precautions should be taken while using DAPATURN GM FORTE 1 TAB?

• Alcohol: Avoid consuming alcohol, as it can significantly increase the risk of hypoglycemia (low blood sugar) and a serious condition called lactic acidosis.
• Medical Conditions: This medicine is not for Type 1 diabetes. Use with caution if you have kidney or liver disease, severe heart problems, low blood pressure, severe infections, dehydration, or a history of pancreatitis.
• Monitoring: Regular monitoring of your blood sugar levels and kidney function is recommended during therapy.
• Driving/Operating Machinery: Be cautious, as the medicine may cause low blood sugar or dizziness, which can impair your ability to drive or operate machinery safely.
• Hydration & Hygiene: Stay well-hydrated throughout the day and maintain good personal hygiene to help prevent urinary tract and genital infections.

What happens if a dose of DAPATURN GM FORTE 1 TAB is missed?

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to compensate for a missed one, as this can lead to dangerously low blood sugar levels.

How should DAPATURN GM FORTE 1 TAB be stored?

DAPATURN GM FORTE 1 TAB should be stored in a cool and dry place, away from direct sunlight. It is best to keep it in its original packaging to protect it from moisture. Ensure the medicine is kept out of the sight and reach of children. The storage temperature should typically be below 30°C (or between 10°C to 25°C).