Mymarda 50 Mg

MYMARDA 50 MG Tablet

MYMARDA 50 MG is a prescription medicine manufactured by Macleods Pharmaceuticals Pvt Ltd. It is an angiotensin receptor neprilysin inhibitor (ARNI) combination medication.

Composition

Each MYMARDA 50 MG tablet contains two active ingredients:

• Sacubitril 24 mg
• Valsartan 26 mg

Uses

MYMARDA 50 MG is primarily used to treat chronic heart failure in adults, specifically those with reduced ejection fraction. Its main purpose is to reduce the risk of cardiovascular death and hospitalization for heart failure. The medication works by relaxing and widening blood vessels, making it easier for the heart to pump blood effectively throughout the body and reducing strain on the heart.

Dosage and Administration

MYMARDA 50 MG should be taken as advised by a healthcare professional. The dosage and duration of treatment will be determined by the doctor based on the individual's medical condition and response to therapy. Tablets should be swallowed whole and not crushed or chewed. For some patients, such as those with moderate renal impairment or specific blood pressure ranges, a starting dose of 50 mg twice daily may be considered, with slow dose titration recommended.

Side Effects

Common side effects include:

• Dizziness, light-headedness (due to low blood pressure)
• Hyperkalemia (high potassium levels), which can manifest as irregular heartbeat or muscle weakness
• Cough
• Decreased renal function or renal impairment
• Nausea, diarrhea, vomiting
• Fatigue, tiredness, weakness, headache

Serious side effects, though rare, can include angioedema (swelling of the face, lips, tongue, or throat), which requires immediate medical attention.

Precautions

• Pregnancy and Breastfeeding: MYMARDA 50 MG is contraindicated during pregnancy and breastfeeding due to potential harm to the fetus or infant.
• Allergies: Do not take if allergic to sacubitril, valsartan, or any other ingredients.
• Liver and Kidney Impairment: Use with caution in patients with liver disease (contraindicated in severe hepatic impairment) or kidney problems.
• Driving and Operating Machinery: This medication may cause dizziness or tiredness; avoid driving or operating heavy machinery if affected.
• Drug Interactions:
  • Should not be taken with ACE inhibitors; a 36-hour washout period is required between discontinuing an ACE inhibitor and starting MYMARDA 50 MG to reduce the risk of angioedema.
  • Avoid concomitant use with aliskiren in patients with diabetes or kidney disease.
  • Caution with potassium supplements, potassium-sparing diuretics (e.g., spironolactone), and NSAIDs, which can increase the risk of hyperkalemia or reduce efficacy.
  • Sildenafil may cause a further decrease in blood pressure when used concurrently.
  • Inform your doctor about all other medications, including over-the-counter drugs and supplements.
• Dietary Considerations: Monitor potassium intake as valsartan can increase potassium levels. Follow any diet restrictions recommended by your healthcare provider.

Storage

Store MYMARDA 50 MG tablets at room temperature, ideally between 15°C to 30°C, away from sunlight and moisture. Keep the medicine in its original packaging and out of the sight and reach of children.

Here are the frequently asked questions about MYMARDA 50 MG:

What is MYMARDA 50 MG used for?

MYMARDA 50 MG is primarily used to treat chronic heart failure in adults, particularly in patients with reduced ejection fraction. It helps to reduce the risk of cardiovascular death and hospitalization due to heart failure.

How does MYMARDA 50 MG work?

MYMARDA 50 MG is a combination medicine containing Sacubitril (24 mg) and Valsartan (26 mg), belonging to a class of drugs called Angiotensin Receptor Neprilysin Inhibitors (ARNIs). Sacubitril works by inhibiting an enzyme called neprilysin, which increases the levels of certain natural substances (natriuretic peptides) in the body that help relax blood vessels and promote fluid excretion. Valsartan is an angiotensin II receptor blocker (ARB) that prevents the action of angiotensin II, a hormone that constricts blood vessels and promotes salt and fluid retention. Together, these actions relax blood vessels, reduce blood pressure, decrease the heart's workload, and improve heart function.

What is the usual dosage for MYMARDA 50 MG?

The dosage of MYMARDA 50 MG is determined by your doctor based on your specific medical condition and response to treatment. It is crucial to follow your doctor's instructions regarding the dose and frequency, and not to exceed or alter it without medical advice. For some patients, a starting dose of 50 mg twice daily may be considered, for instance, in those with moderate renal impairment or specific blood pressure levels, or those not currently taking ACE inhibitors or ARBs. The tablets should be swallowed whole and not crushed or chewed.

What are the possible side effects of MYMARDA 50 MG?

Common side effects of MYMARDA 50 MG can include dizziness, light-headedness, low blood pressure, high blood potassium levels (hyperkalemia), cough, headache, tiredness, weakness, nausea, diarrhea, and decreased kidney function. A serious but rare side effect is angioedema, which involves swelling of the face, lips, tongue, or throat and requires immediate medical attention.

Is MYMARDA 50 MG safe during pregnancy or breastfeeding?

MYMARDA 50 MG is contraindicated during pregnancy, especially after the first three months, as it can cause serious harm to the unborn baby. It is also not recommended for use in breastfeeding women. You should consult your doctor for safer alternative options if you are pregnant, planning to conceive, or breastfeeding.

Can MYMARDA 50 MG be taken with other medications?

You should inform your doctor about all medications you are taking, including over-the-counter drugs and supplements, to avoid potential drug interactions. MYMARDA 50 MG should not be taken with ACE inhibitors; a waiting period of at least 36 hours is required after discontinuing an ACE inhibitor before starting MYMARDA 50 MG. It should also be avoided with aliskiren (especially if you have diabetes or impaired kidney function), potassium-sparing diuretics, potassium supplements, and NSAIDs (Non-Steroidal Anti-Inflammatory Drugs) as these can increase the risk of side effects like hyperkalemia or kidney problems.

What precautions should be taken while using MYMARDA 50 MG?

While taking MYMARDA 50 MG, you should regularly monitor your blood pressure. Exercise caution if you have liver or kidney problems (it is not recommended for severe liver disease). If you have diabetes, regular blood sugar monitoring is necessary. Avoid potassium-rich foods and potassium-containing salt substitutes. Alcohol consumption should be limited or avoided as it can increase the risk of dizziness. If you experience dizziness or tiredness, avoid driving or operating heavy machinery. Also, be aware of a personal or family history of angioedema.

What happens if a dose of MYMARDA 50 MG is missed?

If you forget to take a dose of MYMARDA 50 MG, take it as soon as you remember. However, if it is nearly time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one. Always consult your doctor before making any changes to your dosage.

How should MYMARDA 50 MG be stored?

Store MYMARDA 50 MG tablets at room temperature, ideally between 15°C to 30°C (59°F to 86°F). Keep the medicine in its original packaging to protect it from moisture and sunlight. Ensure it is placed in a safe location, out of reach of children. Always check the expiry date before use and do not use expired medication.