Oxramet Ir 5mg/1000mg Tab

OXRAMET IR 5MG/1000MG TAB

OXRAMET IR 5MG/1000MG TAB is a medication used in the management of Type 2 Diabetes Mellitus, manufactured by Sun Pharmaceutical Industries Ltd. It helps to control high blood glucose levels, particularly when diet and exercise alone are insufficient.

• Composition: Each tablet contains a combination of Dapagliflozin (5mg) and Metformin (1000mg).

  • Dapagliflozin is a gliflozin (SGLT2 inhibitor) that works by helping the kidneys remove excess sugar from the body through urine.
  • Metformin is a biguanide that primarily decreases glucose production in the liver and improves the body's sensitivity to insulin.

• Uses: OXRAMET IR is primarily prescribed for the treatment of Type 2 Diabetes Mellitus. It aids in regulating blood sugar levels, thereby reducing the risk of serious complications associated with uncontrolled diabetes, such as kidney damage, eye damage, nerve issues, and cardiovascular disease.

• Dosage and Administration: The dosage is determined by a doctor based on individual patient needs and blood glucose levels. It is typically taken orally, with meals, usually once or twice daily, to minimize gastrointestinal side effects. The tablet should be swallowed whole with water and not chewed, crushed, or broken. Regular monitoring of blood sugar levels is crucial for effective dosage adjustment.

• Side Effects: Common side effects may include:

  • Sore throat, nasal congestion, runny nose (nasopharyngitis)
  • Headache, dizziness
  • Nausea, vomiting, diarrhea, stomach pain, loss of appetite
  • Genital fungal infections and urinary tract infections
  • Increased frequency of urination (polyuria)
  • Low blood sugar levels (hypoglycemia), especially when used with other antidiabetic medicines or alcohol
  • Skin rash, changes in taste

• Precautions:

  • Inform your doctor about any existing kidney or liver issues, urinary tract infections, or if you are taking diuretics. OXRAMET IR is contraindicated in severe renal impairment.
  • Pregnant or breastfeeding women should consult their healthcare provider before use.
  • Avoid excessive alcohol consumption, as it can increase the risk of lactic acidosis.
  • Stay well-hydrated to prevent dehydration.
  • Regular monitoring of blood sugar levels is important.

• Storage: Store OXRAMET IR tablets at room temperature, below 30°C, away from moisture and heat, and out of reach of children.

What is OXRAMET IR 5MG/1000MG TAB used for?

OXRAMET IR 5MG/1000MG TAB is a combination medication primarily used to manage high blood sugar levels in adults with type 2 diabetes mellitus. It is used as an adjunct to diet and exercise. This medicine can also reduce the risk of cardiovascular death in patients with type 2 diabetes and established cardiovascular disease. Additionally, it helps to lower the risk of worsening kidney disease, hospitalization due to heart failure, and cardiovascular death in patients with type 2 diabetes who also have chronic kidney disease.

How does OXRAMET IR 5MG/1000MG TAB work?

OXRAMET IR contains two active ingredients: Dapagliflozin and Metformin.

• Dapagliflozin works by blocking a protein called sodium-glucose co-transporter 2 (SGLT2) in the kidneys. This prevents the reabsorption of glucose from the urine back into the blood, leading to increased excretion of glucose through urine and thus lowering blood sugar levels.
• Metformin works through multiple mechanisms. It primarily decreases glucose production in the liver, reduces the absorption of glucose from the intestines, and improves the body's sensitivity to insulin, allowing cells to use glucose more effectively.

What is the usual dosage for OXRAMET IR 5MG/1000MG TAB?

The dosage of OXRAMET IR 5MG/1000MG TAB is typically one tablet, taken twice daily with meals. It's crucial to follow your doctor's specific instructions, as they may adjust the dose based on your individual needs and how well your blood sugar levels are controlled. The tablet should be swallowed whole and not crushed, broken, or chewed.

What are the possible side effects of OXRAMET IR 5MG/1000MG TAB?

Common side effects include headache, nausea, diarrhea, vomiting, gas, stomach pain, sore throat, nasal congestion, runny nose, and genital fungal infections. More serious, though rare, side effects can include lactic acidosis (a build-up of lactic acid in the blood), dehydration, urinary tract infections (UTIs) (including severe ones), genital yeast infections, and ketoacidosis. You should seek immediate medical attention if you experience severe muscle pain, unusual tiredness, trouble breathing, stomach discomfort, or any signs of an allergic reaction like rash, hives, or swelling of the face, lips, or throat. There is also a potential increased risk of lower limb amputations, though this is rare.

Is OXRAMET IR 5MG/1000MG TAB safe during pregnancy or breastfeeding?

Pregnancy: OXRAMET IR is not recommended during the second and third trimesters of pregnancy due to potential risks to the unborn baby's kidney development. If you are pregnant, planning to become pregnant, or could become pregnant, discuss birth control options and alternative treatments with your doctor. Breastfeeding: It is generally not recommended to take this medication while breastfeeding. While it's unlikely to pass into breast milk in clinically significant amounts, there's a theoretical risk to the infant's developing kidney. Your doctor may suggest safer alternatives, especially if nursing a newborn or premature infant.

Can OXRAMET IR 5MG/1000MG TAB be taken with other medications?

Yes, but caution is advised, as it can interact with several medications. Your doctor may need to adjust doses or take other precautions. Some medications that can interact include diuretics, certain blood pressure medications, insulin or insulin secretagogues (which can increase the risk of low blood sugar), carbonic anhydrase inhibitors, and iodinated contrast media used in imaging procedures. It's important to inform your doctor about all prescription, over-the-counter, vitamin, and herbal supplements you are taking.

What precautions should be taken while using OXRAMET IR 5MG/1000MG TAB?

Assess your kidney function before starting treatment and regularly thereafter, as the risk of serious side effects like lactic acidosis increases with impaired kidney function. Avoid excessive alcohol consumption, as it can increase the risk of lactic acidosis. Stay well-hydrated to prevent dehydration, especially during exercise or hot weather. Inform your doctor if you have liver disease, heart failure, or a history of urinary tract or genital infections, as these conditions may require special monitoring. You may need to temporarily stop this medicine before surgery or certain medical tests involving contrast dyes. This medication is not for type 1 diabetes.

What happens if a dose of OXRAMET IR 5MG/1000MG TAB is missed?

If you miss a dose, take it as soon as you remember, unless it is almost time for your next scheduled dose. In that case, skip the missed dose and resume your regular dosing schedule. Do not double doses to make up for a missed one.

How should OXRAMET IR 5MG/1000MG TAB be stored?

Store the medicine in its original closed container at room temperature, away from heat, moisture, and direct light. Do not freeze it. Keep it out of reach of children. Dispose of any outdated or no longer needed medicine safely as advised by your healthcare professional.