Rapilif M 25 (10 Tablets)

RAPILIF M 25

RAPILIF M 25 is a medication manufactured by IPCA LABORATORIES LTD, designed to manage symptoms associated with benign prostatic hyperplasia (BPH) complicated by an overactive bladder.

Composition Each tablet of RAPILIF M 25 contains:

• Mirabegron: 25 mg
• Silodosin: 8 mg

Uses RAPILIF M 25 is primarily prescribed for men with Benign Prostatic Hyperplasia (BPH), a non-cancerous enlargement of the prostate gland, particularly when it is accompanied by symptoms of an overactive bladder. It helps alleviate urinary symptoms such as:

• Difficulty in starting urination
• Weak urine stream
• Frequent urination, especially at night (nocturia)
• Sudden, strong urges to urinate (urgency)
• Feeling of incomplete bladder emptying
• Urge urinary incontinence (involuntary leakage of urine)

Mirabegron works by relaxing the bladder muscles, which helps the bladder hold more urine and reduces frequent, urgent, or uncontrollable urination. Silodosin relaxes the muscles around the bladder exit and prostate gland, making it easier to pass urine.

Dosage and Administration RAPILIF M 25 should be taken orally as prescribed by a healthcare professional. It can be taken with or without food, preferably at the same time each day to maintain consistent effectiveness. The tablet should be swallowed whole with a glass of water and not chewed, crushed, or broken. Do not exceed the prescribed dose.

Side Effects Common side effects may include:

• Abnormal ejaculation (e.g., retrograde ejaculation)
• Dizziness
• Increased heart rate
• Nausea
• Constipation
• Urinary tract infections
• Runny or blocked nose (nasal congestion, nasopharyngitis)
• Headache
• Diarrhea
• Orthostatic hypotension (a sudden drop in blood pressure upon standing)

Most of these side effects are usually mild and may resolve over time. However, if they persist or become bothersome, consult your doctor.

Precautions

• Allergies: Do not take RAPILIF M 25 if you are allergic to Mirabegron, Silodosin, or any other ingredients in the medicine.
• Medical Conditions: This medicine is not recommended for individuals with severe kidney disease, severe liver disease, or severe, uncontrolled high blood pressure. Use with caution in patients with mild to moderate kidney or liver impairment and those with ECG abnormalities (QT prolongation).
• Driving and Operating Machinery: RAPILIF M 25 may cause dizziness, especially at the beginning of treatment. Avoid driving or operating heavy machinery until you know how the medication affects you.
• Interactions: Inform your doctor about all other medications, herbal preparations, and supplements you are taking. Interactions can occur with certain antifungals (e.g., ketoconazole, itraconazole), immunosuppressants (e.g., cyclosporine), antivirals (e.g., ritonavir), other alpha-blockers (e.g., doxazosin, tamsulosin), and beta-blockers (e.g., atenolol, propranolol).
• Alcohol: Alcohol consumption may worsen dizziness and drowsiness.
• Surgery: Inform your eye specialist if you are taking this medicine before undergoing cataract or glaucoma eye surgery, as it may cause complications during the procedure.
• Specific Populations: RAPILIF M 25 is intended for use in men. It is not recommended for women (especially pregnant or breastfeeding) or children and adolescents under 18 years of age.

Storage Store RAPILIF M 25 in a cool and dry place, away from direct sunlight, ideally below 30°C. Keep the medicine in its original packaging and out of the sight and reach of children.

RAPILIF M 25 (10 TABLETS) is a medication primarily used to treat symptoms associated with Benign Prostatic Hyperplasia (BPH), particularly when complicated by an overactive bladder. It contains two active ingredients: Mirabegron and Silodosin.

Here are some frequently asked questions about RAPILIF M 25:

What is RAPILIF M 25 used for?

RAPILIF M 25 is prescribed for men to manage the symptoms of Benign Prostatic Hyperplasia (BPH), an enlargement of the prostate gland. This medication is particularly useful when BPH is accompanied by an overactive bladder, addressing symptoms such as frequent urination, urgency, a weak urine stream, difficulty initiating urination, and the feeling of incomplete bladder emptying.

How does RAPILIF M 25 work?

RAPILIF M 25 works through its two active components: Mirabegron and Silodosin. Mirabegron is a bladder muscle relaxant that reduces the activity of an overactive bladder, helping to control urgency and frequency. Silodosin is an alpha-blocker that relaxes the muscles around the bladder exit and prostate gland, making it easier to pass urine and relieving urinary symptoms associated with BPH.

What is the usual dosage for RAPILIF M 25?

The dosage of RAPILIF M 25 should be taken exactly as prescribed by your doctor, as it can vary based on your medical condition. It is generally recommended to swallow the tablet whole with a glass of water, without crushing or chewing it. The medication can be taken with or without food, but maintaining a consistent schedule, ideally taking it at the same time each day, is important for optimal results.

What are the possible side effects of RAPILIF M 25?

Common side effects of RAPILIF M 25 may include abnormal ejaculation (retrograde ejaculation), dizziness, headache, diarrhea, constipation, nausea, nasal congestion, and orthostatic hypotension (a sudden drop in blood pressure upon standing). Most of these side effects are typically temporary and resolve over time. However, if any side effects persist or worsen, it is important to consult your doctor.

Is RAPILIF M 25 safe during pregnancy or breastfeeding?

RAPILIF M 25 is recommended for use in men and is not applicable for women. It is contraindicated for pregnant or breastfeeding women.

Can RAPILIF M 25 be taken with other medications?

It is crucial to inform your doctor about all other medications, including over-the-counter drugs, supplements, and herbal products, you are currently taking to avoid potential interactions. RAPILIF M 25 may interact with certain medicines, such as other alpha-blockers (e.g., doxazosin, tamsulosin), beta-blockers (e.g., atenolol, propranolol), and strong CYP3A4 inhibitors (e.g., ketoconazole, ritonavir, itraconazole, cyclosporine), potentially leading to increased side effects or altered drug levels. Concomitant use with blood pressure medicines should be approached with caution due to the risk of excessive blood pressure lowering.

What precautions should be taken while taking RAPILIF M 25?

Several precautions should be considered:

• Heart Conditions: Use with caution if you have heart problems, as it may raise blood pressure and increase the risk of arrhythmias.
• Liver and Kidney Disease: Inform your doctor if you have liver or kidney diseases, as dosage adjustments may be necessary. It is contraindicated in severe liver or kidney disorders.
• Dizziness: The medication can cause dizziness, so avoid driving or operating heavy machinery until you know how it affects you.
• Cataract Eye Surgery: Inform your eye specialist if you are taking this medicine before undergoing cataract or glaucoma eye surgery, as it may cause complications during the procedure.
• Children: RAPILIF M 25 is not recommended for children and adolescents under 18 years of age.
• Alcohol: Avoid or limit alcohol consumption as it may worsen dizziness.

What happens if a dose of RAPILIF M 25 is missed?

If you miss a dose of RAPILIF M 25, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.

How should RAPILIF M 25 be stored?

Store RAPILIF M 25 at room temperature, ideally below 30°C (or between 10ºC to 25ºC). Keep the medicine in its original packaging to protect it from moisture and direct sunlight. Always keep it out of the sight and reach of children. Ensure to use the medicine before the expiry date printed on the pack.