Rabemac Ls Capsule (10 Cap)

RABEMAC LS CAPSULE (10 CAP) by MACLEODS PHARMACEUTICALS LTD.

Name

• Brand Name: RABEMAC LS CAPSULE, Rabemac LS Capsule SR
• Common Name: Rabeprazole and Levosulpiride capsules

Composition

• Active Ingredients: Each capsule contains Rabeprazole (20 mg) and Levosulpiride (75 mg).
  • Rabeprazole is a proton pump inhibitor (PPI) that reduces stomach acid production by blocking the H+/K+ ATPase enzyme system in the stomach lining.
  • Levosulpiride is a prokinetic agent and dopamine antagonist that improves gastrointestinal motility by stimulating the release of acetylcholine, helping to move food from the stomach more efficiently and preventing reflux.

Uses

RABEMAC LS CAPSULE is prescribed for a range of gastrointestinal conditions:

• Gastroesophageal Reflux Disease (GERD): Manages acid reflux, heartburn, and related symptoms like difficulty swallowing and persistent coughing.
• Peptic Ulcers: Treats and promotes the healing of stomach (gastric) and duodenal ulcers.
• Irritable Bowel Syndrome (IBS): Particularly effective in cases involving bloating and delayed gastric emptying.
• Zollinger-Ellison Syndrome: Manages conditions where the stomach produces excessive acid.
• Functional Dyspepsia: Addresses chronic upper abdominal discomfort, bloating, and nausea without an obvious organic cause.
• Diabetic Gastroparesis: Helps with delayed gastric emptying caused by diabetes.

Dosage and Administration

• Typically, one capsule is taken once daily.
• It is advisable to take RABEMAC LS CAPSULE on an empty stomach, preferably at least one hour before a meal.
• Swallow the capsule whole with water; do not chew, crush, or break it.
• Always follow the dosage and duration prescribed by your doctor.

Side Effects

Common Side Effects:

• Nausea and vomiting.
• Diarrhea, constipation.
• Stomach pain, flatulence.
• Headache, dizziness, drowsiness, weakness, sleepiness.
• Dry mouth, flu-like symptoms.

Serious or Less Common Side Effects:

• Long-term use of rabeprazole may increase the risk of osteoporosis-related bone fractures and hypomagnesemia (low magnesium levels).
• Other reported side effects include breast enlargement in males, altered libido, absence of menstrual periods, and unusual production of breast milk.

Precautions

• Pregnancy and Breastfeeding: Caution is recommended. It is not recommended for use in pregnant or breastfeeding women; consult your doctor.
• Alcohol: Avoid or limit alcohol consumption as it can worsen symptoms and enhance side effects like drowsiness.
• Pre-existing Conditions: Inform your doctor if you have liver disease, kidney disease, pheochromocytoma, epilepsy, mania, gastrointestinal bleeding, intestinal obstruction, or Parkinson's disease, as the medicine may exacerbate these conditions or require caution.
• Driving and Machinery: This medicine may cause dizziness or drowsiness; avoid driving or operating machinery if affected.
• Children: Not recommended for children under 18 years as safety and effectiveness have not been established.
• Drug Interactions:
  • Antifungals (e.g., ketoconazole) may have reduced efficacy.
  • Anticoagulants (e.g., warfarin) may have altered blood-thinning action.
  • Immunosuppressants (e.g., cyclosporine) and antineoplastics (e.g., methotrexate) may interact, potentially altering their effects or increasing toxicity.
  • Antacids should be taken at least 2 hours apart from RABEMAC LS CAPSULE.
  • Inform your doctor about all other medications you are taking.
• Food Interactions: Avoid consuming large amounts of grapefruit or grapefruit juice as it can increase the risk of side effects.

Storage

• Store at room temperature (20-25°C).
• Protect from light and moisture.
• Keep out of reach and sight of children.

What is RABEMAC LS CAPSULE used for?

RABEMAC LS CAPSULE is primarily used to treat various gastrointestinal conditions, including gastroesophageal reflux disease (GERD), peptic ulcers, and irritable bowel syndrome (IBS). It also helps manage conditions like acidity, heartburn, indigestion, Zollinger-Ellison syndrome, and functional dyspepsia.

How does RABEMAC LS CAPSULE work?

This medicine is a combination of two active ingredients: Rabeprazole and Levosulpiride. Rabeprazole is a proton pump inhibitor (PPI) that works by reducing the production of stomach acid. It blocks an enzyme in the stomach lining responsible for acid secretion. Levosulpiride is a prokinetic agent that enhances gastrointestinal motility by increasing the release of acetylcholine, a chemical messenger. This action increases the movement of the stomach and intestines, preventing food and acid from flowing back into the food pipe and improving digestion.

What is the usual dosage for RABEMAC LS CAPSULE?

The dosage of RABEMAC LS CAPSULE is determined by your doctor based on your specific condition and response to the medicine. It is generally advised to take one capsule once a day, preferably on an empty stomach, at least one hour before eating. Swallow the capsule whole with water; do not chew, crush, or break it.

What are the possible side effects of RABEMAC LS CAPSULE?

Common side effects may include nausea, vomiting, diarrhoea, stomach pain, headache, dizziness, drowsiness, dry mouth, flatulence, and constipation. Most side effects are usually mild and temporary, but if they persist or worsen, consult your doctor.

Is RABEMAC LS CAPSULE safe during pregnancy or breastfeeding?

RABEMAC LS CAPSULE is not recommended for use in pregnant or breastfeeding women. If you are pregnant, planning to conceive, or breastfeeding, it is essential to discuss this with your doctor to assess potential risks and benefits. Animal studies have shown harmful effects on the developing baby.

Can RABEMAC LS CAPSULE be taken with other medications?

RABEMAC LS CAPSULE can interact with certain medications. For example, antifungals like ketoconazole may have reduced effectiveness, and the blood-thinning action of warfarin can be affected. Immunosuppressants like cyclosporine and anti-cancer medicines like methotrexate might also interact, potentially altering their effects. It's recommended to take antacids at least 2 hours before or after RABEMAC LS CAPSULE to avoid interactions. Always inform your doctor about all medications you are taking to avoid potential drug interactions.

What precautions should be taken while using RABEMAC LS CAPSULE?

Inform your doctor if you have liver or kidney problems, heart disease, a history of pheochromocytoma, epilepsy, mania, gastrointestinal bleeding, intestinal obstruction, or osteoporosis. Avoid alcohol consumption as it can worsen symptoms and increase side effects like confusion, anxiety, and drowsiness. Prolonged use of rabeprazole may increase the risk of osteoporosis-related bone fractures. This medicine may cause dizziness or drowsiness, so avoid driving or operating heavy machinery if you experience these symptoms. It is not recommended for children and adolescents under 18 years of age.

What happens if a dose of RABEMAC LS CAPSULE is missed?

If you miss a dose, take it as soon as you remember. However, if it's nearly time for your next scheduled dose, skip the missed one and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one.

How should RABEMAC LS CAPSULE be stored?

Store RABEMAC LS CAPSULE at room temperature, ideally below 30 °C. Protect it from direct sunlight, excessive heat, and moisture. Always keep this medication out of the reach of children. Ensure you use it before its expiration date.