Dapavel Trio 500 Mg Tablet (10 Tab)

DAPAVEL TRIO 500 MG TABLET, manufactured by INTAS PHARMACEUTICALS LTD., is a prescription medication designed for the comprehensive management of type 2 diabetes mellitus.

Name

• Brand Name: DAPAVEL TRIO 500 MG TABLET
• Common Name: Sitagliptin, Metformin, and Dapagliflozin combination tablet

Composition Each tablet contains a fixed-dose combination of:

• Sitagliptin Phosphate: 100 mg
• Metformin: 500 mg
• Dapagliflozin: 10 mg

Uses DAPAVEL TRIO 500 MG TABLET is prescribed for adults with type 2 diabetes mellitus to:

• Improve blood sugar control.
• Enhance insulin sensitivity and reduce glucose production.
• Promote glucose excretion through urine.
• Lower the risk of cardiovascular events, including cardiovascular death and hospitalization due to heart failure.
• Reduce the risk of severe kidney disease progression in applicable patients.

Dosage and Administration Take DAPAVEL TRIO 500 MG TABLET exactly as directed by your doctor. It is typically taken once or twice daily, usually with meals to minimize stomach upset. Swallow the tablets whole with a glass of water; do not crush or chew them. Do not discontinue the medication abruptly without consulting your doctor.

Side Effects Common side effects may include:

• Diarrhea, nausea, vomiting, abdominal pain
• Headache
• Hypoglycemia (low blood sugar)
• Urinary tract infections (UTIs)
• Genital fungal infections (mycotic infections)
• Nasopharyngitis, upper respiratory tract infections Serious, though less common, side effects include lactic acidosis and diabetic ketoacidosis. Consult your doctor if any side effects persist or worsen.

Precautions

• Pregnancy & Breastfeeding: Consult your doctor before use; individual risks and benefits must be discussed.
• Alcohol: Limit alcohol consumption, as it can increase the risk of lactic acidosis.
• Drug Interactions: Inform your doctor about all medications you are taking, including insulin, sulfonylureas, rifampicin, digoxin, and diuretics, as interactions may occur.
• Disease States: Use with caution in patients with kidney impairment, liver disease, or a history of pancreatitis. Regular monitoring of kidney function is advisable, especially in the elderly.
• Children: The safety and efficacy in children have not been established.

Storage Store DAPAVEL TRIO 500 MG TABLET in a cool, dry place, away from direct heat and sunlight, ideally below 30°C. Keep it out of the reach of children and pets.

Here are frequently asked questions about DAPAVEL TRIO 500 MG TABLET:

What is Dapavel Trio 500 mg Tablet used for?

Dapavel Trio 500 mg Tablet is an antidiabetic medicine used to manage blood sugar levels in adults with Type 2 Diabetes Mellitus. It is prescribed when diet and exercise alone, or therapy with conventional medicines, are not sufficient. The medication also helps to reduce the risk of cardiovascular death, hospitalization due to heart failure, and the progression of kidney disease in adults with related conditions.

How does Dapavel Trio 500 mg Tablet work?

Dapavel Trio 500 mg Tablet contains a combination of three active ingredients: Dapagliflozin, Sitagliptin, and Metformin.

• Dapagliflozin works by removing excess sugar from the body through urine.
• Sitagliptin increases the levels of certain natural substances that lower blood sugar when it is high, enhances insulin release, and decreases glucagon levels in the body.
• Metformin reduces the amount of sugar produced by the liver, delays sugar absorption from the intestines, and improves the body's sensitivity to insulin.

What is the usual dosage for Dapavel Trio 500 mg Tablet?

The usual starting dose is generally one tablet taken orally once or twice daily, as advised by your doctor. It should be swallowed whole with a glass of water and not crushed, chewed, or broken. Taking the tablet with food is often recommended to minimize gastrointestinal side effects. Your doctor will determine the exact dosage based on your blood sugar levels, kidney function, and other medications you may be taking.

What are the possible side effects of Dapavel Trio 500 mg Tablet?

Common side effects may include genital mycotic infections (fungal infections), urinary tract infections (UTIs), nasopharyngitis (inflammation of the throat and nasal passages), diarrhea, nausea, vomiting, headache, and increased or frequent urination. Less common but serious side effects can include lactic acidosis, diabetic ketoacidosis, acute pancreatitis, and severe allergic reactions. If side effects persist or worsen, consult your doctor.

Is Dapavel Trio 500 mg Tablet safe during pregnancy or breastfeeding?

Dapavel Trio 500 mg Tablet is generally not recommended for use during pregnancy or while breastfeeding. Limited information is available regarding its effects in pregnant or breastfeeding women. It is crucial to consult your doctor if you are pregnant, planning to become pregnant, or breastfeeding.

Can Dapavel Trio 500 mg Tablet be taken with other medications?

It is important to inform your doctor about all other medications, supplements, and herbal products you are currently taking or plan to take. Dapavel Trio 500 mg Tablet may interact with certain medications, including other diabetes medicines like insulin or sulfonylureas (which can lead to extremely low blood sugar levels), diuretics (water pills) that may increase the risk of dehydration and low blood pressure, and some antifungals (e.g., ketoconazole), antivirals (e.g., ritonavir), antibacterials (e.g., clarithromycin), and corticosteroids.

What precautions should be taken while using Dapavel Trio 500 mg Tablet?

Avoid alcohol consumption while taking this medicine, as it can increase the risk of hypoglycemia (low blood sugar) and lactic acidosis. It is not recommended if you have severe liver or kidney disease, respiratory failure, heart failure, or Type 1 diabetes. Stay well-hydrated by drinking plenty of fluids. Regular monitoring of blood sugar levels and kidney function is essential. Do not stop taking the medicine abruptly without consulting your doctor. This medicine is not recommended for children below 18 years of age.

What happens if a dose of Dapavel Trio 500 mg Tablet is missed?

If you miss a dose of Dapavel Trio 500 mg Tablet, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one, as this can cause your blood sugar level to fall rapidly.

How should Dapavel Trio 500 mg Tablet be stored?

Dapavel Trio 500 mg Tablet should be stored in a cool, dry place, typically below 30°C, away from direct sunlight and moisture. Keep it out of the sight and reach of children and pets.