Lipril 10 Tablet

LIPRIL 10 TABLET

LIPRIL 10 TABLET, manufactured by Lupin Ltd, is a medication primarily used for cardiovascular conditions.

• Name:

  • Brand Name: LIPRIL 10 TABLET
  • Common Name (Active Ingredient): Lisinopril

• Composition: LIPRIL 10 TABLET contains Lisinopril 10 mg as its active ingredient.

• Uses: LIPRIL 10 TABLET is prescribed to manage several medical conditions:

  • Hypertension (High Blood Pressure): It belongs to a class of drugs called Angiotensin-Converting Enzyme (ACE) inhibitors, which relax and widen blood vessels to lower blood pressure and reduce the heart's workload.
  • Heart Failure: It helps the heart pump blood more effectively, alleviating symptoms and improving heart function.
  • Prevention of Heart Attack and Stroke: By lowering blood pressure, it reduces the risk of damage to blood vessels in the heart and kidneys.
  • Diabetic Nephropathy: It is used for hypertensive type 2 diabetics with microalbuminuria.
  • Post-Myocardial Infarction (Heart Attack): It is used in hemodynamically stable patients within 24 hours of a heart attack to improve survival rates.

• Dosage and Administration: LIPRIL 10 TABLET should be taken as directed by a doctor. It can be taken with or without food, but ideally at the same time each day. The first dose may be advised at bedtime to mitigate initial dizziness.

  • Adults (Hypertension): Initial dose is typically 10 mg once daily, possibly given at bedtime.
  • Children (6 years and older, Hypertension): Initial dose is 0.07 mg/kg, up to 5 mg once daily.
  • Dosage for heart failure and post-myocardial infarction also varies and should be determined by a healthcare professional. Do not discontinue the medication abruptly, as it may lead to a rise in blood pressure.

• Side Effects: Common side effects include:

  • Headache
  • Dizziness
  • Fatigue/Weakness
  • Cough (can be persistent and dry)
  • Nausea and Diarrhea
  • Increased potassium levels (hyperkalemia) Serious side effects can include angioedema (swelling beneath the skin, especially around the face and throat), which warrants immediate medical attention.

• Precautions:

  • Pregnancy and Breastfeeding: LIPRIL 10 TABLET is not recommended during pregnancy as it can harm the developing baby. Caution is advised during breastfeeding.
  • Allergies: Do not take if allergic to Lisinopril or other ACE inhibitors, or if there's a history of angioedema.
  • Kidney and Liver Issues: Use with caution in patients with kidney problems, and liver problems. Regular monitoring of kidney function, blood pressure, and potassium levels is advisable.
  • Diabetes: May impact blood sugar control, requiring close monitoring of glucose levels.
  • Alcohol: Limit alcohol intake as it may increase side effects like dizziness and low blood pressure.
  • Drug Interactions: Inform your doctor about all medicines, including diuretics (e.g., furosemide), potassium supplements, NSAIDs (e.g., ibuprofen), lithium, and other blood pressure medications (e.g., aliskiren, sacubitril/valsartan), as interactions can occur.
  • High-Potassium Foods: Avoid excessive consumption of high-potassium foods as it can raise blood potassium levels.
  • Driving/Operating Machinery: May cause dizziness; avoid these activities if affected.

• Storage: Store LIPRIL 10 TABLET below 30°C, or at controlled room temperature (20º to 25ºC), protected from direct sunlight, moisture, and heat. Keep out of reach of children and pets.

LIPRIL 10 TABLET, manufactured by LUPIN LTD, contains Lisinopril, an angiotensin-converting enzyme (ACE) inhibitor. It is commonly prescribed for managing high blood pressure and certain heart conditions.

Here are some frequently asked questions about LIPRIL 10 TABLET:

What is LIPRIL 10 TABLET used for?

LIPRIL 10 TABLET (Lisinopril) is used to treat high blood pressure (hypertension), either alone or in combination with other medications. It is also prescribed to manage certain types of heart failure and to improve survival after a heart attack. In some cases, it's used to prevent kidney problems in individuals with diabetes mellitus.

How does LIPRIL 10 TABLET work?

Lisinopril, the active ingredient in LIPRIL 10 TABLET, is an ACE inhibitor. It works by blocking the action of an enzyme called angiotensin-converting enzyme (ACE), which is responsible for producing angiotensin II. Angiotensin II is a substance that narrows blood vessels and increases blood pressure. By blocking its production, Lisinopril relaxes and widens blood vessels, making it easier for the heart to pump blood throughout the body. This lowers blood pressure and reduces the workload on the heart.

What is the usual dosage of LIPRIL 10 TABLET?

The dosage of LIPRIL 10 TABLET varies depending on the condition being treated and individual patient factors. For high blood pressure in adults, the usual starting dose is 10 mg once daily, which may be increased up to a maximum of 40 mg per day. For heart failure, the initial adult dose is typically 5 mg once daily, with a maximum of 40 mg per day. After a heart attack, the initial dose is often 5 mg once daily, with specific titration schedules. For children aged 6 years and older with high blood pressure, the dose is based on body weight. Always follow your doctor's instructions for dosage.

What are the possible side effects of LIPRIL 10 TABLET?

Common side effects can include headache, dizziness, feeling tired, and a persistent dry cough. Other possible side effects include nausea, diarrhea, and rash. More serious, but less common, side effects can include low blood pressure (especially when standing up), high blood potassium levels (hyperkalemia), kidney problems, and liver problems. A severe allergic reaction called angioedema (swelling of the face, lips, tongue, or throat) is a rare but serious side effect that requires immediate medical attention.

Is LIPRIL 10 TABLET safe during pregnancy or breastfeeding?

LIPRIL 10 TABLET (Lisinopril) is generally not recommended during pregnancy. It carries a boxed warning from the FDA due to the risk of harm to the fetus, especially during the second and third trimesters, which can lead to kidney problems, lung problems, or skeletal changes in the baby. If you become pregnant while taking Lisinopril, contact your doctor immediately.

Regarding breastfeeding, the FDA states it is unknown whether Lisinopril is excreted in human milk. While some studies suggest minimal transfer into breast milk, it is generally advised to avoid it, especially for newborns or premature infants, due to concerns about potential neonatal hypotension. Your doctor can help determine the best course of action.

Can LIPRIL 10 TABLET be taken with other medications?

LIPRIL 10 TABLET can interact with several other medications. It should not be taken with medications containing aliskiren (like Tekturna) if you have diabetes or kidney disease. It also should not be taken with sacubitril/valsartan (Entresto) due to an increased risk of angioedema; a 36-hour washout period is required between these drugs. Other medications that may interact include:

• Diuretics (water pills): Can lead to a severe drop in blood pressure.
• NSAIDs (non-steroidal anti-inflammatory drugs): Such as ibuprofen or naproxen, can reduce Lisinopril's effectiveness and increase the risk of kidney damage.
• Potassium-sparing diuretics or potassium supplements: Can increase potassium levels in the blood, leading to hyperkalemia.
• Lithium: Lisinopril can increase lithium levels in the body.
• Antidiabetic medications (insulin, oral hypoglycemic agents): Can increase the risk of low blood sugar. Always inform your doctor about all medications, supplements, and herbal products you are taking.

What precautions should be taken while on LIPRIL 10 TABLET?

It's important to monitor for symptoms like severe or continuing nausea, vomiting, or diarrhea, as these can lead to dehydration and low blood pressure. Avoid salt substitutes and potassium supplements unless advised by your doctor, as Lisinopril can increase potassium levels. Be cautious when standing up quickly, as dizziness or lightheadedness may occur. Inform your doctor if you have kidney or liver disease, diabetes, or a history of angioedema.

What happens if a dose of LIPRIL 10 TABLET is missed?

If you miss a dose of LIPRIL 10 TABLET, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a forgotten one.

How should LIPRIL 10 TABLET be stored?

Store LIPRIL 10 TABLET at room temperature, typically between 20° to 25°C (68° to 77°F). Protect it from moisture, freezing, and excessive heat. Keep the container tightly closed and out of reach of children.