Gliptagreat Dm 1000

GLIPTAGREAT DM 1000

GLIPTAGREAT DM 1000 is a prescription medication manufactured by Mankind Pharma Ltd. used for the management of Type 2 Diabetes Mellitus.

Composition

GLIPTAGREAT DM 1000 contains a combination of three active antidiabetic ingredients:

• Dapagliflozin 10mg: A sodium-glucose cotransporter-2 (SGLT-2) inhibitor, which promotes the excretion of excess glucose through urine.
• Metformin 1000mg: A biguanide that reduces glucose production by the liver and decreases glucose absorption from the intestines.
• Vildagliptin 100mg: A dipeptidyl peptidase-4 (DPP-4) inhibitor that enhances glucose-mediated insulin secretion and reduces glucose production by the liver.

Uses

GLIPTAGREAT DM 1000 is prescribed for adults with Type 2 Diabetes Mellitus to help control high blood sugar levels. It is used as an adjunct to diet and exercise to improve glycemic control by improving insulin sensitivity, reducing glucose production, and increasing glucose excretion. Beyond glycemic control, it also contributes to cardiovascular and renal protection, helping to reduce the risk of heart failure and kidney complications, and supports weight and metabolic control.

Dosage and Administration

This medicine should be taken orally with food to minimize gastrointestinal side effects. The tablet should be swallowed whole with a glass of water and not crushed, broken, or chewed. Adhere strictly to the dosage and duration advised by your healthcare provider. Do not exceed the prescribed dose or discontinue the medication without consulting your doctor.

Side Effects

Common side effects may include:

• Vomiting, nausea, abdominal pain, diarrhea
• Headache, dizziness, fatigue
• Frequent urination, painful urination, urinary tract infection
• Low blood sugar (hypoglycemia), which can manifest as sweating, confusion, shakiness, anger, or a fast heartbeat
• Vaginal yeast infection, inflammation of the penis (in men)
• Bad taste in the mouth

Serious but rare side effects can include lactic acidosis, a condition where lactic acid accumulates in the body, and abnormal liver function.

Precautions

• Allergies: Do not use if you are allergic to dapagliflozin, metformin, vildagliptin, or any other components of the medicine.
• Pregnancy and Breastfeeding: It is not recommended for pregnant or breastfeeding women; consult your doctor if you are pregnant, planning to conceive, or breastfeeding.
• Pediatric Use: Not recommended for use in children below 18 years of age.
• Alcohol: Avoid alcohol consumption as it increases the risk of hypoglycemia and lactic acidosis.
• Medical Conditions: Inform your doctor about your complete medical history, especially if you have kidney or liver disease, heart problems, hypertension, type 1 diabetes, diabetic ketoacidosis, metabolic acidosis, history of lactic acidosis, severe dehydration, or vitamin B12/folic acid deficiency.
• Drug Interactions: Inform your doctor about all current medications, supplements, and herbal products you are taking, as GLIPTAGREAT DM 1000 can interact with other antidiabetic medications, diuretics, birth control pills, certain antivirals, thyroid medicines, corticosteroids, and others.
• Procedures: Inform your doctor if you are scheduled for any surgery, X-ray, or scanning procedures.
• Driving: Exercise caution when driving or operating machinery as the medicine may cause dizziness.
• Diet: Maintain a healthy diet, avoid high-sugar and high-fat foods, and avoid grapefruit or grapefruit juice.
• Monitoring: Regular monitoring of blood sugar levels is essential.

Storage

Store GLIPTAGREAT DM 1000 in a cool, dry place at room temperature (20-25°C) or below 30°C. Protect it from direct sunlight and moisture, and keep it out of the sight and reach of children and pets.

GLIPTAGREAT DM 1000 by MANKIND PHARMA LTD. - Frequently Asked Questions

What is GLIPTAGREAT DM 1000 used for?

GLIPTAGREAT DM 1000 is an antidiabetic medicine primarily used as an adjunct to diet and exercise to improve glycemic control in adults with Type 2 Diabetes Mellitus (T2DM). It helps to control high blood sugar levels. Beyond blood sugar management, it also helps reduce the risk of cardiovascular diseases, hospitalisation due to heart failure, and kidney complications associated with diabetes.

How does GLIPTAGREAT DM 1000 work?

GLIPTAGREAT DM 1000 is a combination of three active ingredients: Dapagliflozin, Metformin, and Vildagliptin.

• Dapagliflozin works by inhibiting the reabsorption of glucose in the kidneys, leading to increased excretion of excess glucose through urine and thus lowering blood glucose levels.
• Metformin helps control blood sugar by reducing the amount of sugar the liver makes, decreasing sugar absorption from the intestines, and enhancing the body's sensitivity to insulin.
• Vildagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor that improves glycemic control by increasing the levels of incretin hormones (GLP-1 and GIP), which promote insulin release from the pancreas and signal the liver to stop producing sugar when blood sugar is high.

What is the usual dosage for GLIPTAGREAT DM 1000?

The dosage and duration of GLIPTAGREAT DM 1000 are determined by your doctor based on your age, body weight, and medical condition. It should be taken as advised by your physician, swallowed whole with a glass of water, and not crushed or chewed. It is generally recommended to take this medicine with food to minimize gastrointestinal side effects.

What are the possible side effects of GLIPTAGREAT DM 1000?

Common side effects of GLIPTAGREAT DM 1000 can include low blood sugar levels (hypoglycemia), painful urination, repetitive or frequent urination, inflammation of the penis (in men), vaginal yeast infections, urinary tract infections, diarrhea, nausea, vomiting, abdominal pain, headache, and fatigue. A rare but serious side effect, lactic acidosis, can occur due to metformin accumulation, with symptoms like muscle pain, dizziness, tiredness, stomach pain, and difficulty breathing.

Is GLIPTAGREAT DM 1000 safe during pregnancy or breastfeeding?

GLIPTAGREAT DM 1000 is generally not recommended for use in pregnant or breastfeeding women. Limited information is available on its use during pregnancy, and animal studies have shown harmful effects on the developing baby. It is known to pass into breast milk, which may harm the baby. Always consult your doctor if you are pregnant, planning to conceive, or breastfeeding.

Can GLIPTAGREAT DM 1000 be taken with other medications?

It is crucial to inform your doctor about all current medications, supplements, or herbal products you are taking to avoid potential interactions. GLIPTAGREAT DM 1000 can interact with:

• Other diabetic medications (e.g., insulin, glyburide, rosiglitazone), which may increase the risk of low blood sugar.
• Diuretics (water pills like furosemide, hydrochlorothiazide) can lead to excessive water loss and potentially increase the risk of dehydration and low blood pressure.
• Birth control pills, thyroid medicines (e.g., levothyroxine), corticosteroids (e.g., prednisone), anti-epileptics (e.g., phenytoin), and certain cardiovascular agents (e.g., nifedipine, digoxin).
• If you require an iodine-based contrast medium for an X-ray or scan, your doctor may advise you to stop taking GLIPTAGREAT DM 1000 temporarily.

What precautions should be taken with GLIPTAGREAT DM 1000?

• Alcohol: Consumption of alcohol is not recommended as it can lower blood sugar levels and increase the risk of serious complications like lactic acidosis.
• Kidney/Liver Disease: Use with caution in patients with kidney problems, and it is generally unsafe for those with severe liver disease. Your doctor may adjust the dose or prescribe an alternative.
• Heart Problems: Caution is advised for patients with heart problems or a history of heart attack.
• Surgery/Procedures: Inform your doctor if you are scheduled for surgery, x-ray, or scanning procedures.
• Vitamin B12/Folic Acid Deficiency: Inform your doctor if you have these deficiencies.
• Do not drive or use machinery if you feel dizzy after taking this medicine.

What happens if a dose of GLIPTAGREAT DM 1000 is missed?

If you miss a dose of GLIPTAGREAT DM 1000, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one, as this can cause your blood sugar level to fall rapidly.

How should GLIPTAGREAT DM 1000 be stored?

GLIPTAGREAT DM 1000 should be stored in a cool, dry place away from direct sunlight and moisture, and kept out of the sight and reach of children and pets. Store at room temperature (20-25°C or below 30°C).