Zivast F Tablet ( 10 Tab )

ZIVAST F TABLET (10 TAB) by FDC LIMITED

ZIVAST F TABLET is a combination medication manufactured by FDC LIMITED, designed to effectively manage lipid levels in the blood and reduce the risk of cardiovascular diseases.

Composition

ZIVAST F TABLET contains two active ingredients:

• Atorvastatin (10 mg): This belongs to the statin class of drugs, which works by inhibiting cholesterol production in the liver.
• Fenofibrate (160 mg): This is a fibrate that primarily works by increasing the breakdown of triglycerides and helps to increase good cholesterol (HDL) levels.

Uses

ZIVAST F TABLET is prescribed for the following medical conditions:

• Treatment of high cholesterol (hypercholesterolemia): It helps lower low-density lipoprotein (LDL or "bad") cholesterol and total cholesterol levels.
• Treatment of high triglycerides (hypertriglyceridemia): It reduces elevated triglyceride levels, which can minimize the risk of pancreatitis and heart disease.
• Treatment of mixed dyslipidemia: This is a condition characterized by abnormal levels of both cholesterol and triglycerides in the blood.
• Prevention of heart attack and stroke: By improving lipid profiles and reducing plaque buildup in arteries (atherosclerosis), it helps prevent cardiovascular events.
• Prevention of coronary artery disease and slowing the progression of atherosclerosis.

Dosage and Administration

The recommended dosage of ZIVAST F TABLET varies based on individual patient factors, including the severity of the condition and response to medication.

• It is typically taken once daily, with or without food, preferably at the same time each day to maintain consistent medication levels.
• The tablets should be swallowed whole with a glass of water; they should not be chewed, crushed, or broken.
• Adhere strictly to your physician's prescribed dosage and schedule.

Side Effects

Common side effects of ZIVAST F TABLET may include:

• Muscle pain, tenderness, or weakness (myalgia)
• Headache
• Nausea, stomach pain, indigestion, diarrhea, constipation, flatulence
• Increased blood sugar levels
• Increased liver enzymes
• Insomnia

Serious side effects, though less common, require immediate medical attention:

• Severe unexplained muscle pain or weakness, particularly if accompanied by fever, malaise, or reddish-brown urine, which could indicate rhabdomyolysis.
• Signs of liver damage such as yellowing of the skin or eyes (jaundice), fever, rash, loss of appetite, vomiting, fatigue, or dark urine.

Precautions

• Liver Disease: ZIVAST F TABLET is not recommended for patients with severe liver or gallbladder problems and should be used with caution in individuals with other liver issues. Regular monitoring of liver function is necessary during treatment.
• Kidney Disease: Caution is advised in patients with kidney disease, and dosage adjustment may be required.
• Pregnancy and Breastfeeding: This medicine is highly unsafe during pregnancy (Category X) and is generally not recommended for breastfeeding women as it may pass into breast milk.
• Alcohol Consumption: Avoid consuming alcohol as it can increase triglyceride levels and the risk of liver damage.
• Drug Interactions: Inform your doctor about all medications you are taking. It should not be taken with Fusidic acid. Avoid grapefruit and grapefruit juice as they can increase atorvastatin levels.
• Muscle Disorders: Inform your doctor if you have a muscle disorder (e.g., fibromyalgia) or a family history of muscle problems.
• Diabetes: Diabetic patients should monitor their blood sugar levels regularly as the medicine might impact blood sugar control.
• Do not discontinue the medication without consulting your healthcare provider, as this can worsen your condition.

Storage

Store ZIVAST F TABLET at room temperature, below 25°C or 30°C, away from direct sunlight, moisture, and heat. Keep it out of sight and reach of children.

Here are some frequently asked questions about ZIVAST F TABLET:

What is ZIVAST F TABLET used for?

ZIVAST F TABLET is a combination medication primarily used to manage high cholesterol and triglyceride levels in the blood. It is prescribed to treat conditions like hyperlipidemia, mixed dyslipidemia, hypercholesterolemia, and hypertriglyceridemia. By lowering these lipid levels, it helps reduce the risk of cardiovascular events such as heart attack, stroke, and the progression of atherosclerosis (plaque buildup in arteries). This medicine is typically used when diet and exercise alone have not been sufficient to control cholesterol levels.

How does ZIVAST F TABLET work?

ZIVAST F TABLET contains two active ingredients: Atorvastatin and Fenofibrate. Atorvastatin belongs to a class of drugs called statins. It works by inhibiting an enzyme in the liver (HMG-CoA reductase) that is essential for cholesterol production, thereby lowering "bad" cholesterol (LDL-C) and total cholesterol. Fenofibrate is a fibrate that works by increasing the breakdown of triglycerides and increasing the levels of "good" cholesterol (HDL-C) in the blood. The combined action of these two components provides a comprehensive approach to managing abnormal lipid levels.

What is the usual dosage for ZIVAST F TABLET?

ZIVAST F TABLET is usually taken once daily, with or without food. The specific dosage will be determined by your doctor based on your individual needs, the severity of your condition, and your response to the treatment. It is crucial to adhere strictly to the prescribed dosage and not to discontinue the medication without consulting your healthcare provider.

What are the possible side effects of ZIVAST F TABLET?

Common side effects of ZIVAST F TABLET can include muscle pain, tenderness, or weakness (myalgia), headache, nausea, diarrhea, abdominal discomfort, indigestion, and increased blood sugar levels. If you experience severe unexplained muscle pain or weakness, especially if accompanied by fever or reddish-brown urine, you should contact your doctor immediately. Most side effects are temporary and resolve as your body adjusts to the medication.

Is ZIVAST F TABLET safe during pregnancy or breastfeeding?

No, ZIVAST F TABLET is contraindicated during pregnancy and is considered unsafe for pregnant women due to potential risks to the fetus. Women of childbearing potential should use a suitable contraceptive method to avoid pregnancy while undergoing therapy with this medicine. It is also not recommended for use in breastfeeding women as it is known to pass into breast milk and can affect the baby's health.

Can ZIVAST F TABLET be taken with other medications?

ZIVAST F TABLET can interact with several other medications. Inform your doctor about all medicines, supplements, or herbal products you are currently taking or might take to avoid potential interactions. Some medications that may interact include:

• Immunosuppressants (e.g., cyclosporine, tacrolimus)
• Certain antibiotics (e.g., clarithromycin, erythromycin, fusidic acid)
• Antiviral medications (e.g., ritonavir, lopinavir, glecaprevir, pibrentasvir)
• Blood thinners (e.g., warfarin)
• Other cholesterol-lowering medications (e.g., niacin, gemfibrozil)
• Antifungal medications (e.g., itraconazole)
• Colchicine These interactions can increase the risk of side effects like muscle problems or alter the effectiveness of the medications.

What precautions should be taken while taking ZIVAST F TABLET?

Several precautions should be taken:

• Liver and Kidney Function: Regular monitoring of liver function tests is recommended as ZIVAST F TABLET can affect the liver. It should be used with caution in patients with kidney disease, and dosage adjustment may be necessary.
• Alcohol Consumption: Avoid drinking large amounts of alcohol as it can increase the risk of liver damage.
• Grapefruit Juice: Avoid consuming grapefruit juice as it can increase the blood levels of atorvastatin, potentially leading to increased side effects.
• Muscle Pain: Report any unexplained muscle pain, tenderness, or weakness to your doctor promptly.
• Diabetes: If you have diabetes, blood sugar levels should be closely monitored as the medicine might impact blood sugar control.
• Gallbladder Disease: It is contraindicated in patients with gallbladder disease.
• Hypothyroidism: Inform your doctor if you have an underactive thyroid.
• Lifestyle: This medication should be used as part of a comprehensive treatment plan that includes a healthy diet, regular exercise, and weight management.

What happens if a dose of ZIVAST F TABLET is missed?

If you miss a dose of ZIVAST F TABLET, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up.

How should ZIVAST F TABLET be stored?

ZIVAST F TABLET should be stored at room temperature, away from direct sunlight, moisture, and heat. Keep the medicine out of sight and reach of children and pets.