Sacu V 50 Mg Tablet (14 Tab)

SACU V 50 MG TABLET (14 TAB) by GLENMARK PHARMACEUTICALS LTD.

Name

Brand Name: SACU V 50 Tablet Common Name: Sacubitril and Valsartan

Composition

Each SACU V 50 Tablet contains two active ingredients:

• Sacubitril: 24 mg
• Valsartan: 26 mg

Uses

SACU V 50 Tablet is primarily used for the treatment of chronic heart failure with reduced ejection fraction in adults. It helps to improve symptoms, reduce the risk of hospitalization, and decrease the risk of cardiovascular death in patients with long-lasting heart failure. The medication aids in managing symptoms such as breathlessness, fatigue, and fluid retention (e.g., ankle swelling) by improving the heart's pumping action. It can also be used in children above one year of age with heart failure.

Dosage and Administration

SACU V 50 Tablet should be taken as prescribed by a healthcare professional.

• The dosage and frequency are determined based on the individual's condition and response to treatment.
• It can be taken with or without food, but it is recommended to take it regularly at the same time each day to maximize benefits.
• Swallow the tablet whole; do not chew, crush, or break it.
• Do not stop taking the medication without consulting your doctor, even if you feel well, as it is crucial for preventing future complications.

Side Effects

Common Side Effects:

• Low blood pressure (hypotension), which may cause dizziness or light-headedness.
• High potassium levels in the blood (hyperkalemia).
• Cough.
• Impaired kidney function or increased serum creatinine.
• Dizziness, fainting, or spinning sensation (vertigo).
• Nausea, diarrhea, or stomach pain.
• Weakness or tiredness.
• Headache.

Serious Side Effects (Seek immediate medical attention if experienced):

• Angioedema (severe allergic reactions such as swelling of the face, lips, tongue, or throat, which may cause difficulties in breathing or swallowing).

Precautions

• Pregnancy and Breastfeeding: SACU V 50 Tablet is contraindicated in pregnancy, especially during the second and third trimesters, as it can cause serious harm to the fetus. It is not recommended for use in breastfeeding women.
• Drug Interactions: Do not take SACU V 50 Tablet with ACE inhibitors (e.g., captopril or enalapril) and allow at least 36 hours between taking an ACE inhibitor and SACU V 50 Tablet due to an increased risk of side effects like angioedema. Inform your doctor about all other medications, including over-the-counter drugs and supplements, especially those for blood pressure or heart conditions, lithium, and potassium-containing mineral supplements.
• Medical Conditions: Inform your doctor if you have kidney or liver diseases, diabetes, a history of angioedema, low blood pressure, vomiting, or diarrhea.
• Alcohol: It is advisable to avoid alcohol while taking this medication as it may increase the risk of dizziness and low blood pressure.
• Driving and Operating Machinery: This medicine may cause dizziness or tiredness; avoid driving or operating heavy machinery if you experience these symptoms.
• Monitoring: Regular monitoring of blood pressure, kidney function, and potassium levels is advised during treatment.

Storage

Store SACU V 50 Tablet in a cool and dry place, ideally at a temperature not exceeding 30°C. Keep it protected from light and moisture to maintain its effectiveness. Always ensure the medicine is kept out of the sight and reach of children.

Here are some frequently asked questions about SACU V 50 MG TABLET:

What is SACU V 50 MG TABLET used for?

SACU V 50 MG TABLET is primarily used to treat chronic heart failure in adults, particularly those with reduced ejection fraction. It helps to reduce the risk of hospitalization and cardiovascular death in these patients by improving the heart's pumping efficiency and managing symptoms like breathlessness, fatigue, and fluid retention.

How does SACU V 50 MG TABLET work?

This medicine is a combination of two active ingredients: Sacubitril and Valsartan, belonging to a class of drugs called Angiotensin Receptor Neprilysin Inhibitors (ARNIs). Sacubitril works by inhibiting the enzyme neprilysin, which increases the levels of beneficial peptides that help relax blood vessels and reduce fluid retention. Valsartan is an angiotensin receptor blocker (ARB) that blocks the action of angiotensin II, a hormone that narrows blood vessels. Together, they relax and widen blood vessels, making it easier for the heart to pump blood, thereby reducing the workload on the heart and improving its function.

What is the usual dosage of SACU V 50 MG TABLET?

The dosage and frequency of SACU V 50 MG TABLET will be determined by your doctor based on your individual medical condition and response to the medication. It is crucial to take the tablets regularly at the same time each day as prescribed. Do not stop taking the medication without consulting your doctor, even if you feel well.

What are the possible side effects of SACU V 50 MG TABLET?

Common side effects may include low blood pressure (hypotension), high potassium levels in the blood (hyperkalemia), cough, dizziness, headache, nausea, diarrhea, fainting, and weakness. Some more severe, but rare, side effects can include angioedema (swelling of the face, lips, tongue, or throat) which requires immediate medical attention. If you experience severe or persistent side effects, inform your doctor promptly.

Is SACU V 50 MG TABLET safe during pregnancy or breastfeeding?

SACU V 50 MG TABLET is not recommended during early pregnancy and is contraindicated in pregnant women beyond the first three months of pregnancy due to the risk of serious harm to the developing baby. It is also not recommended for use in breastfeeding women. Always consult your doctor if you are pregnant, planning to conceive, or breastfeeding.

Can SACU V 50 MG TABLET be taken with other medications?

SACU V 50 MG TABLET can interact with several other medications. It should not be taken with ACE inhibitors (e.g., enalapril, lisinopril) and a period of at least 36 hours should pass between stopping an ACE inhibitor and starting Sacu-V, or vice versa. Concomitant use with aliskiren (especially in patients with diabetes or kidney disease), NSAIDs (non-steroidal anti-inflammatory drugs), potassium-sparing diuretics, potassium supplements, and lithium can also lead to adverse effects or reduced effectiveness. Inform your doctor about all medications, supplements, and herbal products you are currently taking.

What precautions should be taken while taking SACU V 50 MG TABLET?

Before starting treatment, inform your doctor if you have kidney or liver diseases, diabetes, a history of angioedema, or low blood pressure. You should avoid or limit alcohol consumption as it can increase the blood pressure-lowering effect and risk of dizziness. If you experience dizziness or lightheadedness, rise slowly from sitting or lying positions. Regular monitoring of blood pressure and kidney function may be advised during treatment. Following a low-sodium diet is also recommended to support heart health. Avoid driving or operating heavy machinery if you experience dizziness or tiredness.

What happens if a dose of SACU V 50 MG TABLET is missed?

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.

How should SACU V 50 MG TABLET be stored?

Store SACU V 50 MG TABLET in a cool and dry place, ideally at a temperature not exceeding 30°C. Keep the product protected from light and moisture to maintain its effectiveness. Always ensure the medicine is kept out of reach of children.