Sitaday M 1000

SITADAY M 1000 is a combination medication used for the management of Type 2 Diabetes Mellitus in adults. Manufactured by Mankind Pharma Ltd., it helps to control high blood sugar levels when diet and exercise alone are insufficient, and when either sitagliptin or metformin alone is not enough to manage the condition. By improving blood sugar control, it aims to reduce the risk of diabetes-related complications such as kidney damage, blindness, nerve problems, heart-related issues, and sexual dysfunction.

Name

• Common Name: SITADAY M 1000 Tablet
• Brand Name: SITADAY M 1000 (by Mankind Pharma Ltd.)

Composition SITADAY M 1000 Tablet contains two active ingredients:

• Sitagliptin (50 mg): This acts as a DPP-4 inhibitor, which increases the release of insulin from the pancreas and reduces glucagon secretion in a glucose-dependent manner.
• Metformin (1000 mg): This is a biguanide that reduces glucose production in the liver, decreases glucose absorption from the intestines, and enhances insulin sensitivity in the body's peripheral areas.

Uses SITADAY M 1000 is prescribed for the management of Type 2 Diabetes Mellitus in adults. It helps to improve glycemic control and can be used alone or in conjunction with other diabetes medications, along with a healthy diet and regular exercise.

Dosage and Administration

• The dosage should be taken as advised by a doctor, as it can vary based on individual health conditions and response to the medicine.
• Tablets should be swallowed whole with a glass of water, typically during meals to reduce gastrointestinal side effects.
• Do not break, chew, or crush the tablet.
• It is important to take the medicine regularly, ideally at the same time each day, and not to stop unless advised by a doctor.

Side Effects Common side effects may include:

• Diarrhea
• Nausea and Vomiting
• Abdominal pain/stomach upset
• Headache
• Upper respiratory tract infections (e.g., runny nose, sore throat, coughing)
• Flatulence
• Low blood sugar levels (hypoglycemia), especially when taken with other diabetes medications like insulin or sulfonylurea.
• Metallic taste in the mouth.
• Drowsiness/dizziness

Serious but rare side effects include:

• Lactic acidosis, a medical emergency with symptoms like deep or rapid breathing, persistent nausea, vomiting, stomach pain, muscle pain or weakness, dizziness, tiredness, cold feeling in arms and legs.
• Severe allergic reactions (hives, swelling of face/lips/tongue/throat causing difficulty breathing or swallowing).
• Severe blistering of the skin (bullous pemphigoid).
• Pancreatitis (severe and persistent stomach pain that might reach the back, with or without nausea and vomiting).
• Long-term use can lead to Vitamin B12 deficiency.

Precautions

• Pregnancy and Breastfeeding: Not recommended during pregnancy and breastfeeding. Consult a doctor if pregnant, planning to conceive, or breastfeeding.
• Alcohol: Avoid consuming alcohol as it can increase the risk of lactic acidosis and hypoglycemia.
• Kidney/Liver Problems: Use with caution in patients with liver problems and not recommended for severe kidney impairment.
• Heart Disease: Should be used with caution in patients with heart disease requiring pharmacologic management and is contraindicated in some cases.
• Other Medical Conditions: Inform your doctor about any history of pancreatitis, high blood cholesterol, severe systemic infections, or recent severe dehydration. Contraindicated in Type 1 diabetes and diabetic ketoacidosis.
• Drug Interactions: Medicines like insulin, insulin secretagogues (e.g., glimepiride), and salicylates (e.g., aspirin) can increase the risk of low blood sugar. Some beta-blockers may mask hypoglycemia symptoms.
• Monitoring: Regular monitoring of blood sugar levels and kidney function is recommended.

Storage Store SITADAY M 1000 Tablet at room temperature below 30°C, away from sunlight and moisture. Keep it out of reach of children and pets.

SITADAY M 1000 is a medication manufactured by Mankind Pharma Ltd., used to manage Type 2 Diabetes Mellitus in adults. It combines two active ingredients: Sitagliptin (50 mg) and Metformin (1000 mg). This combination helps improve blood sugar control when diet and exercise alone, or either metformin or sitagliptin by themselves, are not sufficient.

What is SITADAY M 1000 used for?

SITADAY M 1000 is primarily used for the management of Type 2 Diabetes Mellitus in adults. It helps control high blood sugar levels and, by doing so, reduces the risk of serious diabetes-related complications such as kidney damage, blindness, nerve problems, heart-related issues, and sexual dysfunction.

How does SITADAY M 1000 work?

This medicine combines two different mechanisms of action. Sitagliptin, a DPP-4 inhibitor, works by increasing the release of insulin from the pancreas and reducing glucagon secretion in a glucose-dependent manner. This helps regulate blood sugar levels, especially after meals. Metformin, a biguanide, reduces the production of glucose in the liver, decreases the absorption of glucose from the intestines, and enhances the body's sensitivity to insulin, allowing it to use glucose more effectively.

What is the usual dosage?

The daily dose of SITADAY M 1000 should be taken as advised by your doctor. The dosage can vary based on individual factors like your health condition and how you respond to the medicine. It is crucial to adhere to the prescribed dosage and take it regularly, ideally with food to minimize stomach upset. Tablets should be swallowed whole with a glass of water and not crushed, chewed, or broken.

What are the possible side effects?

Common side effects of SITADAY M 1000 include gastrointestinal issues such as diarrhea, nausea, vomiting, abdominal pain, and flatulence. Other common side effects may include headaches, upper respiratory tract infections (like runny nose, sore throat, and coughing), and low blood sugar levels (hypoglycemia), especially if taken with other diabetes medications. Serious but rare side effects can include lactic acidosis and pancreatitis.

Is it safe during pregnancy or breastfeeding?

SITADAY M 1000 is generally not recommended during pregnancy or breastfeeding. It is considered unsafe during pregnancy as it may cause harmful effects to the fetus. Metformin, one of its components, is known to be excreted in human breast milk, making it potentially unsafe during breastfeeding. Always consult with your doctor if you are pregnant, planning to conceive, or breastfeeding.

Can it be taken with other medications?

SITADAY M 1000 can interact with several medications. For instance, taking it with insulin or insulin secretagogues (like glimepiride or gliclazide) can increase the risk of low blood sugar. Salicylates, such as aspirin, can also enhance its glucose-lowering effect. It's crucial to inform your doctor about all other medications you are currently taking, including over-the-counter drugs and supplements, to avoid potential interactions. Certain blood pressure medications (ACE inhibitors, ARBs), corticosteroids, and diuretics may also interact.

What precautions should be taken?

Before taking SITADAY M 1000, inform your doctor if you have a history of kidney, liver, or heart disease, pancreatic problems, or if you consume alcohol excessively. Patients with severe kidney or liver impairment, congestive heart failure, or those with a history of lactic acidosis should avoid this medication. Alcohol consumption should be avoided as it can increase the risk of lactic acidosis and hypoglycemia. Regular monitoring of blood sugar levels and kidney function is recommended during treatment. Long-term use can lead to Vitamin B12 deficiency.

What happens if a dose is missed?

If you forget to take a dose of SITADAY M 1000, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed one and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. Always consult your doctor before altering your dose.

How should it be stored?

SITADAY M 1000 tablets should be stored at room temperature below 30°C, away from sunlight and moisture. Keep the medication out of the sight and reach of children and pets. Ensure you use the medicine before its expiry date.