Glucreta M 10+ 1000 Tablet (10 Tab)

GLUCRETA M 10+1000 TABLET is a combination medication manufactured by Torrent Pharmaceuticals Ltd., primarily used for the management of type 2 diabetes mellitus. It helps to control high blood sugar levels and may reduce the risk of diabetes-related complications and heart disease.

Name

• Brand Name: GLUCRETA M 10+1000 TABLET (ER - Extended Release formulation is also mentioned in some sources)
• Common Name: Dapagliflozin and Metformin tablets

Composition

Each tablet contains:

• Dapagliflozin: 10 mg
• Metformin Hydrochloride: 1000 mg (often in a sustained-release or extended-release formulation)

Uses

GLUCRETA M 10+1000 TABLET is prescribed for:

• Managing blood sugar levels in adults with type 2 diabetes mellitus.
• Improving glycemic control when diet and exercise alone are insufficient.
• Reducing the risk of heart disease and heart failure in patients with type 2 diabetes.
• It can be used alone or in combination with other diabetes medications, including insulin or GLP-1 receptor agonists.

Dosage and Administration

• Typically, it is prescribed to be taken orally once daily, usually in the morning, or once or twice daily, as directed by a healthcare provider.
• It should generally be taken with meals to minimize gastrointestinal side effects and improve absorption.
• Swallow the tablet whole; do not crush, chew, or break it.
• The exact dosage and duration are determined by the doctor based on the patient's medical condition and response to treatment.

Side Effects

Common Side Effects:

• Nausea, vomiting, diarrhea, abdominal pain, or stomach upset.
• Headache, dizziness.
• Genital fungal infections.
• Urinary tract infections (UTIs) and increased urination frequency.
• Nasal congestion, runny nose, sore throat (nasopharyngitis).
• Mild skin rash or itching.

Serious Side Effects (less common but require immediate medical attention):

• Lactic acidosis (symptoms include muscle cramps, severe abdominal pain, difficulty breathing, general weakness).
• Dehydration.
• Kidney problems.
• Hypoglycemia (low blood sugar), especially when used with other antidiabetic medicines or alcohol.
• Allergic reactions (rash, swelling, difficulty breathing).

Precautions

• Kidney and Liver Conditions: Use with caution in patients with liver problems and not recommended for those with moderate to severe kidney disease due to the risk of lactic acidosis.
• Alcohol Consumption: Avoid excessive alcohol consumption as it can increase the risk of lactic acidosis and hypoglycemia.
• Dehydration: Stay well-hydrated, as the medication can increase urination and lead to dehydration.
• Pregnancy and Breastfeeding: Consult a doctor, as safety during pregnancy and breastfeeding is not fully established, and animal studies have shown potential harmful effects.
• Drug Interactions: Inform your doctor about all other medications, supplements, or herbal remedies you are taking, especially diuretics, insulin, insulin secretagogues, and carbonic anhydrase inhibitors.
• Monitoring: Regular monitoring of blood sugar levels is crucial.

Storage

• Store at room temperature, away from moisture and heat.
• Keep in a cool and dry place, typically below 30°C.
• Keep out of sight and reach of children.

What is GLUCRETA M 10+ 1000 Tablet used for?

GLUCRETA M 10+ 1000 Tablet is primarily used to manage blood sugar levels in adults with type 2 diabetes mellitus. It is prescribed when diet and exercise alone are not sufficient to control blood sugar, or when a single medication therapy doesn't provide adequate control. This medicine can also help reduce the risk of serious complications of diabetes, such as kidney damage, and may offer cardiovascular benefits, including a reduced risk of heart attack or heart failure in certain patients.

How does GLUCRETA M 10+ 1000 Tablet work?

GLUCRETA M 10+ 1000 Tablet is a combination medication containing two active ingredients: Dapagliflozin (10mg) and Metformin (1000mg).

• Dapagliflozin works by inhibiting a protein in the kidneys called sodium-glucose co-transporter 2 (SGLT2). This protein is responsible for reabsorbing glucose from the urine back into the bloodstream. By blocking SGLT2, dapagliflozin causes excess glucose to be excreted through the urine, thereby lowering blood sugar levels.
• Metformin belongs to the biguanide class of antidiabetic drugs. It primarily works by decreasing glucose production in the liver and reducing the absorption of glucose from the intestine. Metformin also helps improve the body's sensitivity to insulin, allowing cells to utilize glucose more effectively.

What is the usual dosage for GLUCRETA M 10+ 1000 Tablet?

The exact dosage of GLUCRETA M 10+ 1000 Tablet will be determined by your doctor based on your individual medical condition and response to treatment. It is typically taken orally, usually once daily with food, preferably with your main meal, to help minimize gastrointestinal side effects. The tablet should be swallowed whole and not crushed or chewed. Always follow your doctor's instructions carefully and do not alter your dosage without consulting them.

What are the possible side effects of GLUCRETA M 10+ 1000 Tablet?

Common side effects may include genital fungal infections, urinary tract infections (UTIs), nausea, vomiting, diarrhea, headache, and nasopharyngitis (symptoms similar to the common cold, such as a sore throat, stuffy or runny nose). You might also experience increased urination and dehydration; drinking plenty of fluids can help mitigate these. Less common but serious side effects can include lactic acidosis (a rare but severe complication, particularly with excessive alcohol intake or pre-existing kidney/liver issues), significant dehydration, kidney problems, and hypoglycemia (low blood sugar), especially when taken with other diabetes medications like insulin or sulfonylureas. If you experience any severe or persistent side effects, contact your doctor immediately.

Is GLUCRETA M 10+ 1000 Tablet safe during pregnancy or breastfeeding?

Pregnancy: The safety of GLUCRETA M 10+ 1000 Tablet during pregnancy has not been fully established. It should only be used if the potential benefit justifies the potential risk to the fetus and is generally not recommended during the second and third trimesters. Always consult your doctor if you are pregnant or planning to conceive.

Breastfeeding: It is not fully known whether GLUCRETA M 10+ 1000 Tablet passes into breast milk, and its safety for breastfeeding women is uncertain. It is considered probably unsafe during breastfeeding. Consult your doctor before using this medication while breastfeeding.

Can GLUCRETA M 10+ 1000 Tablet be taken with other medications?

It is crucial to inform your doctor about all medicines, supplements, or herbal remedies you are currently taking or plan to take, as GLUCRETA M 10+ 1000 Tablet can interact with certain drugs.

• Taking it with diuretics (e.g., furosemide, hydrochlorothiazide) may increase the risk of dehydration and low blood pressure.
• When used with insulin or insulin secretagogues (e.g., glipizide, glimepiride), there is an increased risk of low blood sugar (hypoglycemia).
• Carbonic anhydrase inhibitors (e.g., acetazolamide) may increase the risk of lactic acidosis.
• It should not be used with iodinated contrast agents (used for certain X-rays) or some medicines used to treat stomach acidity, such as cimetidine.
• Interactions can also occur with certain antidiabetic medicines, anticoagulants, antilipidemic agents, anti-TB agents, NSAIDs, and anticonvulsants.

What precautions should be taken while using GLUCRETA M 10+ 1000 Tablet?

• Do not take this medicine if you have a known allergy to dapagliflozin, metformin, or any other ingredient in the tablet.
• Use with caution if you have kidney or liver problems, as the medication could potentially worsen these conditions; it is not recommended for moderate to severe kidney disease or liver disease.
• Avoid excessive alcohol consumption while taking this medication, as it can significantly increase the risk of lactic acidosis and low blood sugar.
• Patients with a history of urinary tract infections may experience an increase in infection frequency due to dapagliflozin.
• This medicine is not indicated for type 1 diabetes or diabetic ketoacidosis.
• Your ability to drive or operate machinery may be affected if your blood sugar levels become too low or too high.
• Regular monitoring of your blood sugar levels, along with maintaining a balanced diet and regular exercise, is essential.
• GLUCRETA M 10+ 1000 Tablet is intended for adults and should not be given to children under 18 without medical advice. Caution is also advised for elderly patients.

What happens if a dose of GLUCRETA M 10+ 1000 Tablet is missed?

If you forget to take a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to compensate for the missed one. Missing doses can lead to elevated blood sugar levels. If you miss multiple doses or have concerns about a missed dose, contact your doctor for advice.

How should GLUCRETA M 10+ 1000 Tablet be stored?

GLUCRETA M 10+ 1000 Tablet should be stored at room temperature, ideally between 15°C and 30°C (59°F and 86°F). Keep the medication protected from moisture and heat. Always store it out of the sight and reach of children.