Metafort G 851

METAFORT G 851 Tablet

METAFORT G 851 is an oral anti-diabetic medication manufactured by Eris Lifesciences Ltd. It is designed to help manage blood sugar levels in adults with Type 2 Diabetes Mellitus.

Composition

Each tablet contains a combination of two active ingredients:

• Glimepiride (1 mg): A sulfonylurea that stimulates the pancreatic beta cells to release more insulin.
• Metformin (850 mg): A biguanide that reduces glucose production in the liver, delays glucose absorption from the intestines, and increases insulin sensitivity in peripheral tissues like muscles.

Uses

METAFORT G 851 is prescribed for:

• Treatment of Type 2 Diabetes Mellitus in adults, especially when diet and exercise alone are insufficient to control blood sugar levels.
• Management of high blood glucose levels.
• Improving the body's response to insulin and preventing long-term complications associated with uncontrolled diabetes, such as kidney problems, blindness, nerve damage, and heart disease.
• Supporting patients unresponsive to single medicine therapy.

Dosage and Administration

• The daily dose should be taken as prescribed by your doctor.
• Dosage may vary based on individual blood sugar levels and response to treatment.
• It is typically taken once or twice daily with meals.
• Swallow the tablet whole without crushing, chewing, or breaking it.
• Consistency is key; take it at the same time each day for optimal results.
• Do not adjust the dose or stop the medication without consulting your doctor.

Side Effects

Common Side Effects:

• Diarrhoea
• Nausea and Vomiting
• Abdominal discomfort/Stomach pain
• Metallic taste
• Hypoglycaemia (low blood sugar levels), which can cause symptoms like sweating, shakiness, confusion, dizziness, and hunger.
• Headache
• Loss of appetite

Serious Side Effects (Contact your doctor immediately if you experience these):

• Lactic acidosis (dangerous acid buildup in the blood)
• Inflammation of the liver, potentially leading to jaundice (yellowing of skin or eyes)
• Severe allergic reactions (e.g., skin rash, hives, increased sun sensitivity, inflammation of blood vessels, difficulty breathing, fall in blood pressure, shock)
• Severe low blood sugar levels, including loss of consciousness or seizures.

Precautions

• Contraindications: Not recommended for individuals with severe kidney or liver disease, Type 1 diabetes mellitus, diabetic ketoacidosis, or a history of lactic acidosis. It is also generally not recommended during pregnancy or breastfeeding.
• Alcohol: Avoid alcohol completely while using METAFORT G 851, as it can increase the risk of low blood sugar and lactic acidosis.
• Kidney/Liver Disease: Caution is advised. Dose adjustment may be necessary, and regular monitoring of kidney and liver function tests is recommended.
• Hypoglycaemia Risk: Be aware of symptoms of low blood sugar. Carry a fast-acting source of glucose (e.g., sugary food or fruit juice).
• Drug Interactions: May interact with insulin and other antidiabetics (increased risk of hypoglycaemia), beta-blockers (can mask hypoglycaemia symptoms), NSAIDs, diuretics, and certain kidney-affecting medicines. Inform your doctor about all current medications.
• Driving/Operating Machinery: Exercise caution, as altered blood sugar levels can cause dizziness or visual problems.
• Children: Not suitable for children and adolescents under 18 years of age.

Storage

• Store in a cool, dry place at temperatures not exceeding 30°C.
• Keep the medicine protected from direct light and moisture.
• Store in the original packaging until ready to use.
• Keep out of reach of children and pets.
• Do not use after the expiry date.

Here are frequently asked questions about METAFORT G 851 by ERIS LIFESCIENCES LTD:

What is Metafort-G 851 used for?

Metafort-G 851 is an anti-diabetic medication primarily used to manage type 2 diabetes mellitus in adults. It is prescribed when diet, exercise, and a single diabetes medication are not enough to control blood sugar levels effectively. This combination medicine helps to improve glycemic control and reduce the risk of diabetes-related complications such as kidney damage, nerve problems, eye damage, and cardiovascular issues.

How does Metafort-G 851 work?

Metafort-G 851 contains two active ingredients: Glimepiride (1mg) and Metformin (850mg). Glimepiride, a sulfonylurea, works by stimulating the beta cells in the pancreas to produce and release more insulin, which helps lower blood glucose levels. Metformin, a biguanide, works by reducing the amount of sugar produced by the liver (hepatic gluconeogenesis), delaying the absorption of sugar from the intestines, and increasing the body's sensitivity to insulin, allowing cells to use glucose more effectively. Both components contribute to improving blood glucose control and insulin sensitivity.

What is the usual dosage of Metafort-G 851?

The appropriate dosage of Metafort-G 851 is determined by your doctor based on your individual needs and blood sugar readings, which may require adjustments over time. It is crucial to take this medication with food at the same time every day for optimal results. Always follow your healthcare provider's instructions regarding dosage and duration of treatment.

What are the possible side effects of Metafort-G 851?

Common side effects of Metafort-G 851 include headache, hypoglycemia (low blood glucose level), nausea, diarrhea, stomach pain, vomiting, and a metallic taste in the mouth. These are generally mild and may decrease as your body adjusts to the medication. More serious, though rare, side effects can include lactic acidosis (an accumulation of lactic acid in the body), severe hypoglycemia, and allergic reactions. It is vital to recognize symptoms of hypoglycemia like sweating, dizziness, and trembling and be prepared with a fast-acting glucose source. If side effects persist or worsen, or if you experience symptoms of serious side effects, seek immediate medical attention.

Is Metafort-G 851 safe during pregnancy or breastfeeding?

Metafort-G 851 is generally not recommended or considered unsafe during pregnancy. Animal studies have shown potential harm to the developing baby, and it may be unsafe to use during pregnancy. If you are pregnant or planning pregnancy, consult your doctor, as they may suggest an alternative. It should also be avoided during breastfeeding as it may pass into breast milk and potentially cause adverse effects in the baby.

Can Metafort-G 851 be taken with other medications?

Metafort-G 851 can interact with other medications. Taking it with other antidiabetic medicines like insulin or gliclazide can increase the risk of low blood sugar (hypoglycemia). Corticosteroids (e.g., prednisolone, dexamethasone) can reduce its effectiveness by raising blood glucose levels. Diuretics (water tablets) may decrease its effectiveness and increase the risk of metformin toxicity. Medicines that affect kidney function can also interfere with metformin elimination, increasing side effect risks. Alcohol consumption should be avoided as it significantly increases the risk of hypoglycemia and a serious condition called lactic acidosis. Always inform your doctor about all medicines, supplements, or herbal products you are currently taking to avoid potential interactions.

What precautions should be taken with Metafort-G 851?

Several precautions should be observed:

• Medical Conditions: It is not suitable for individuals with type 1 diabetes mellitus, diabetic ketoacidosis, or severe kidney or liver conditions. Inform your doctor about any history of heart disease, metabolic acidosis, or severe infections.
• Alcohol: Avoid alcohol due to increased risks of hypoglycemia and lactic acidosis.
• Dehydration: Be vigilant for signs of dehydration (e.g., vomiting, diarrhea) as it can increase side effect risks.
• Surgery/Imaging: Inform your doctor before any surgery or X-ray procedures involving contrast dye, as metformin may need to be stopped temporarily.
• Driving: Exercise caution when driving or operating machinery as the medication can affect alertness due to blood sugar fluctuations.
• Monitoring: Regular monitoring of blood sugar levels is essential. Your doctor may also recommend additional blood tests to assess blood cell counts and liver function.
• Do not stop abruptly: Do not stop taking the medication without consulting your doctor, as this can lead to elevated blood sugar levels and serious health risks.

What happens if a dose of Metafort-G 851 is missed?

If you forget to take your Metafort-G 851, take it as soon as you remember. However, if it's close to the time for your next scheduled dose, skip the missed dose and continue with your regular dosing routine. Do not take a double dose to make up for a missed one, as this can increase the risk of hypoglycemia. Consistency in taking your medication as prescribed is important.

How should Metafort-G 851 be stored?

Store Metafort-G 851 in a cool and dry place, away from direct sunlight and moisture. The recommended temperature range is generally between 15°C to 30°C (59°F to 86°F), or below 30°C. Keep the medicine in its original packaging until ready to use and ensure it is out of the reach and sight of children and pets. Do not use the medicine after its expiry date.