Estrabet Gel 80 Gm

ESTRABET GEL 80 GM by ABBOTT INDIA LIMITED

Estrabet Gel 80 GM is a topical hormone replacement therapy (HRT) containing estradiol, a form of estrogen. It is manufactured by Abbott India Limited and is primarily used to alleviate symptoms associated with menopause.

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Name

• Common Name: Estrabet Gel
• Brand Name: ESTRABET GEL 80 GM

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Composition

• Active Ingredient: Estradiol 0.06% w/w. Estradiol is a bioidentical form of 17 beta estradiol, a female sex hormone.

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Uses Estrabet Gel is prescribed for Hormone Replacement Therapy (HRT) to manage various conditions primarily related to estrogen deficiency, especially during menopause.

• Menopausal Symptoms: It is used to prevent and treat hot flashes (hot flushes), night sweats, and mood swings.
• Vaginal Discomfort: It alleviates vaginal itching, dryness, and burning sensations (atrophic vaginitis) often experienced during menopause.
• Osteoporosis Prevention: Estrabet Gel helps prevent and manage postmenopausal osteoporosis, which involves the thinning and weakening of bones, thereby reducing the risk of fractures.
• Estrogen Deficiency: It addresses symptoms arising from a decrease in estrogen levels in the body.
• Other Uses: In some specific cases, it may be prescribed for urethritis or vaginal atrophy.

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Dosage and Administration Estrabet Gel is for external (topical) use only and should be applied as advised by a healthcare professional.

• Application: Apply a thin layer to clean, dry, unbroken skin on areas such as one arm (from wrist to shoulder), the front of the thigh, or the inner arm.
• Drying: Allow the gel to dry completely before covering the area with clothing.
• Frequency: It is typically applied once daily, preferably at the same time each day to maintain stable hormone levels.
• Hygiene: Wash hands thoroughly with soap and water immediately after application to prevent accidental transfer to sensitive areas like eyes or mouth.
• Important Notes:
  • Do not apply to breasts or genital areas.
  • Avoid showering, bathing, or swimming for at least an hour after application.
  • Do not exceed the recommended dose.
  • If a dose is missed, apply it as soon as remembered. However, if it is close to the time for the next scheduled dose, skip the missed dose and continue with the regular schedule.

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Side Effects As with any medication, Estrabet Gel can cause side effects, though not everyone experiences them.

• Common Side Effects: Headache, breast pain or tenderness, diarrhea, gas or flatulence, heartburn, irregular vaginal bleeding or spotting, abdominal cramps or bloating, nausea, vomiting, hair loss, lower abdominal pain, and skin irritation at the application site. Most of these are temporary and resolve over time.
• Serious Side Effects (uncommon, but require immediate medical attention): These may include breast cancer, ovarian cancer, uterus cancer, stroke, heart attack, blood clots (in legs or lungs), gallbladder disease, and dementia. Seek immediate medical attention if you experience symptoms like breast lumps, unusual vaginal bleeding, dizziness, faintness, severe or persistent headaches, chest pain, shortness of breath, unexplained swelling and pain in limbs, or changes in vision.

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Precautions

• Allergies: Do not use if you are allergic to estradiol or any other component of the gel.
• Medical History: Inform your doctor about any history of hysterectomy, abnormal vaginal bleeding, heart attack, stroke, breast cancer, blood clots, high blood pressure, high cholesterol, diabetes, liver or kidney problems, asthma, migraine, seizures, uterine fibroids, or endometriosis.
• Pregnancy and Breastfeeding: Estrabet Gel is generally considered unsafe and not recommended during pregnancy or breastfeeding.
• Flammability: Avoid smoking or going near an open flame until the gel has completely dried on the skin, as it may be flammable.
• Other Medications: Discuss all other medications, including over-the-counter drugs and herbal supplements, with your doctor to avoid potential interactions.
• Regular Check-ups: Regular breast examinations, including self-exams and mammograms, are crucial as HRT may increase the risk of breast cancer.
• Special Populations: Not recommended for use in children. It should not be applied to the face.
• Contraindications: Contraindicated in individuals with pre-existing conditions such as angioedema, depression, high blood pressure, blood clotting disorders, or thrombophlebitis.

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Storage

• Store Estrabet Gel in a cool and dry place, away from direct sunlight.
• Keep it out of the sight and reach of children.
• The recommended storage temperature is typically between 10ºC to 25ºC or below 30ºC.
• Do not freeze the gel.

ESTRABET GEL 80 GM is a hormone replacement therapy (HRT) containing estradiol, a form of estrogen. It is primarily used to manage symptoms associated with menopause.

What is Estrabet Gel used for?

Estrabet Gel is primarily used to alleviate moderate to severe menopausal symptoms such as hot flashes, night sweats, vaginal dryness, itching, and burning sensations. It can also be prescribed to help prevent postmenopausal osteoporosis (thinning and weakening of bones) in women at high risk of fractures. In some specific cases, it may be used alongside other medications for the treatment of breast or prostate cancer.

How does Estrabet Gel work?

Estrabet Gel contains estradiol, which is a key female sex hormone (estrogen). During menopause, the body's natural estrogen levels decline, leading to various symptoms. By applying Estrabet Gel, the estradiol is absorbed through the skin into the bloodstream, effectively replacing the diminished estrogen. This helps to restore hormonal balance, thereby reducing menopausal symptoms and contributing to bone health by inhibiting bone resorption.

What is the usual dosage of Estrabet Gel?

The typical dosage involves applying Estrabet Gel to the skin once a day. For estradiol gel 0.06%, 1.25 grams per day is a common approved dose. The gel should be applied to a clean, dry area of skin, such as one arm from the shoulder to the wrist, or on the upper thigh. It is important to allow the gel to dry completely before dressing and to avoid washing the application site for at least one hour after application to ensure proper absorption. Your doctor will determine the appropriate dose and duration of treatment based on your individual needs.

What are the possible side effects of Estrabet Gel?

Common side effects include headache, breast pain or tenderness, irregular vaginal bleeding or spotting, abdominal cramps or bloating, nausea, vomiting, gas, diarrhea, weight gain, and irritation or redness at the application site. More serious, but rare, side effects can include liver injury, stroke, blood clots, heart attack, and an increased risk of certain cancers (uterine, breast, ovarian) or dementia. It's important to discuss any persistent or concerning side effects with your doctor.

Is Estrabet Gel safe during pregnancy or breastfeeding?

Estrabet Gel is considered highly unsafe during pregnancy as studies have shown significant harmful effects to the developing baby. It is also generally considered unsafe during breastfeeding, as data suggests the drug may cause toxicity to the baby. Always inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding before using this medication.

Can Estrabet Gel be taken with other medications?

It is crucial to inform your doctor about all medications you are currently taking, including over-the-counter drugs, herbal supplements, and vitamins, to avoid potential interactions. Estradiol can affect thyroid hormone levels, which may necessitate an adjustment in the dosage of thyroid replacement therapy if you are taking it. If you have a uterus, your doctor may prescribe a progestogen alongside Estrabet Gel to help reduce the risk of endometrial cancer.

What precautions should be taken while using Estrabet Gel?

Do not use Estrabet Gel if you have undiagnosed abnormal vaginal bleeding, a history of certain cancers (such as breast or uterine cancer), blood clots, a stroke, a heart attack, liver problems, or an allergy to estradiol. Inform your doctor about any pre-existing medical conditions like diabetes, high blood pressure, high cholesterol, gallbladder disease, lupus, migraines, kidney disease, or thyroid disease. Regular medical check-ups, including breast exams and mammograms, are recommended. Avoid smoking and proximity to open flames until the gel has dried, as it contains alcohol and may be flammable. Do not apply the gel to your face.

What happens if a dose of Estrabet Gel is missed?

If you miss a dose of Estrabet Gel and remember it within 12 hours of your usual application time, you should apply the missed dose. However, if more than 12 hours have passed, skip the missed dose and continue with your regular dosing schedule. Do not apply a double dose to make up for a missed one.

How should Estrabet Gel be stored?

Estrabet Gel should be stored in a cool and dry place, away from direct sunlight. It should be kept at room temperature, typically between 10ºC to 25ºC or below 30ºC. Always keep the medication out of sight and reach of children and pets.