Triolsar 20

TRIOLSAR 20 by TORRENT PHARMACEUTICALS LTD

Name: TRIOLSAR 20 (Commonly known as TRIOLSAR 20mg Tablet or TRIOLSAR 20 HS Tablet).

Composition: TRIOLSAR 20 is a combination medication containing three active ingredients:

• Amlodipine (5mg)
• Chlorthalidone (6.25mg)
• Olmesartan Medoxomil (20mg)

Uses: TRIOLSAR 20 is primarily prescribed for the management of hypertension (high blood pressure). It also helps to reduce the risk of cardiovascular events such as heart attack and stroke. Additionally, it may be used to manage heart failure, protect kidney function in patients with both hypertension and type II diabetes mellitus, and reduce fluid retention (edema) in the body.

Dosage and Administration: This medicine is typically taken orally once daily, with or without food. It is advisable to take it at the same time each day. Due to its diuretic component, it is best to avoid taking it close to bedtime. The tablet should be swallowed whole. The exact dosage and duration will be determined by a healthcare professional based on the patient's condition and response to treatment. It is crucial not to stop taking the medication without consulting a doctor.

Side Effects:

• Common Side Effects: Headache, dizziness, tiredness, weakness, ankle swelling, stomach upset (nausea, vomiting, diarrhea, constipation), flu-like symptoms, sore throat, runny nose, cough, high blood uric acid levels, low blood sodium or magnesium levels, high blood potassium levels, low blood pressure, impotence in men, increased blood cholesterol levels, changes in taste, palpitations, sleepiness, and flushing.
• Serious Side Effects: May include chest pain, allergic reactions (rash, itching, severe dizziness, trouble breathing), severe skin reactions, inflammation of the pancreas, and liver problems (abdominal pain, yellowing of skin/eyes).

Precautions:

• TRIOLSAR 20 is not recommended for pregnant or breastfeeding women.
• Avoid alcohol consumption and grapefruit/grapefruit juice as they may increase side effects or lower blood pressure.
• Use with caution in patients with liver or kidney problems, diabetes, coronary artery diseases, or a history of heart conditions.
• Not recommended for children under 18 years of age.
• Regular monitoring of blood pressure, kidney function, electrolyte levels, and blood sugar is advised.
• Driving or operating machinery should be avoided if dizziness or drowsiness occurs.

Storage: Store TRIOLSAR 20 in a cool, dry place away from direct sunlight and moisture, preferably between 10ºC and 25ºC or below 30ºC. Keep out of reach of children.

TRIOLSAR 20 is a combination medication used to treat high blood pressure (hypertension). It contains three active ingredients: Amlodipine, Olmesartan, and Chlorthalidone. This combination works to relax blood vessels, remove excess fluid, and reduce the workload on the heart, thereby lowering blood pressure and decreasing the risk of associated cardiovascular events like heart attack and stroke.

What is TRIOLSAR 20 used for?

TRIOLSAR 20 is primarily used to manage high blood pressure (hypertension) in adults. It can also be prescribed to reduce the risk of heart attack, stroke, and heart failure, and may protect kidney function, especially in diabetic patients with hypertension. It can also help reduce fluid retention (edema) caused by certain kidney or liver conditions.

How does TRIOLSAR 20 work?

TRIOLSAR 20 combines three different types of medications:

• Olmesartan Medoxomil (an Angiotensin II Receptor Blocker - ARB) works by blocking the action of a hormone called angiotensin II, which normally causes blood vessels to narrow. By blocking this, it allows blood vessels to relax and widen, reducing blood pressure.
• Amlodipine (a Calcium Channel Blocker) relaxes and widens blood vessels by blocking calcium channels in artery walls, which helps improve blood flow and oxygen supply to the heart.
• Chlorthalidone (a thiazide-like diuretic) increases the removal of excess water and electrolytes (like sodium and chloride) from the body through urine. This reduces fluid volume, improving blood flow and further lowering blood pressure.

These three components work together to provide comprehensive blood pressure control.

What is the usual dosage for TRIOLSAR 20?

The daily dose of TRIOLSAR 20 should be taken exactly as prescribed by your doctor. It is typically recommended to take it once daily, preferably in the mornings, and can be taken with or without food. Consistency in taking the medicine at the same time each day is important. Your doctor will determine the correct dose and duration of therapy based on your individual health condition and response to the medication.

What are the possible side effects of TRIOLSAR 20?

Common side effects can include headache, dizziness, tiredness, weakness, and nausea. Other possible side effects are ankle swelling, fatigue, stomach upset, low blood pressure, high blood uric acid levels, high blood potassium levels, low blood sodium or magnesium levels, sore throat, runny nose, cough, flu-like symptoms, urinary tract infections, increased blood cholesterol levels, and blurred vision. If any side effects persist or worsen, contact your doctor.

Is TRIOLSAR 20 safe during pregnancy or breastfeeding?

TRIOLSAR 20 is generally not recommended for use during pregnancy, especially during the second and third trimesters, as it may cause serious harm to the developing fetus. It is also not recommended for use during breastfeeding, as it may pass into breast milk and potentially harm the nursing infant. Always consult your doctor for advice if you are pregnant, planning to become pregnant, or breastfeeding.

Can TRIOLSAR 20 be taken with other medications?

It is crucial to inform your doctor about all medicines, supplements, or herbal products you are currently taking or plan to take to avoid potential drug interactions. TRIOLSAR 20 can interact with:

• Other blood pressure medications (e.g., ACE inhibitors, beta-blockers)
• Antifungals (e.g., ketoconazole, itraconazole)
• Antivirals (e.g., ritonavir, indinavir, nelfinavir)
• Antibiotics (e.g., rifampicin, erythromycin, clarithromycin)
• Potassium supplements or potassium-sparing diuretics (e.g., spironolactone) as it can increase blood potassium levels.
• Non-steroidal anti-inflammatory drugs (NSAIDs) like ibuprofen or aspirin, which may reduce its effectiveness or increase kidney damage risk.
• Lithium, potentially increasing its toxicity.
• Colesevelam (used for cholesterol).
• Immunosuppressants and anti-HIV medicines.

What precautions should be taken while using TRIOLSAR 20?

Before taking TRIOLSAR 20, inform your doctor if you have any liver or kidney problems, diabetes, severe high or low blood pressure, heart problems (such as narrowing of heart valves, cardiogenic shock, or a recent heart attack), dehydration, or very low blood sodium, potassium, or magnesium levels. Avoid consuming alcohol, as it can further lower blood pressure and increase dizziness. Grapefruit juice should also be avoided as it can increase the levels of amlodipine in your blood and lead to increased side effects. Do not drive or operate heavy machinery if you experience dizziness or drowsiness. Do not stop taking the medication abruptly without consulting your doctor, as this can cause your blood pressure to rise again.

What happens if a dose is missed?

If you miss a dose of TRIOLSAR 20, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one.

How should TRIOLSAR 20 be stored?

Store TRIOLSAR 20 in a cool, dry place, away from direct sunlight and moisture. Keep it out of reach of children and pets. Always check the expiry date before taking the medication.