Sitared Md Xr 500

Name

• Common Name: Sitared-MD XR 500 Tablet
• Brand Name: SITARED MD XR 500 (by SUN PHARMACEUTICALS INDUSTRIES LTD)

Composition SITARED MD XR 500 contains a combination of three active ingredients:

• Dapagliflozin (10 mg)
• Metformin (500 mg)
• Sitagliptin (100 mg)

Uses SITARED MD XR 500 Tablet is prescribed for the management of type 2 diabetes mellitus in adults. It is used when diet, exercise, and therapy with conventional medicines do not result in an adequate response. This medication works by reducing glucose production, enhancing insulin response, and promoting glucose excretion through urine. Additionally, it can aid in weight management and helps reduce the risk of cardiovascular disease and diabetic kidney disease in some patients.

Dosage and Administration Take SITARED MD XR 500 Tablet exactly as advised by your physician. It can be taken with or without meals, though taking it after meals may help avoid stomach upset. Swallow the tablet whole with a glass of water; do not crush, chew, or break it. It is recommended to take the medicine at the same time every day for optimal benefits. Do not stop taking this medicine without consulting your doctor.

Side Effects Common Side Effects:

• Hypoglycemia (low blood glucose level)
• Nausea, vomiting, diarrhea, constipation, stomach pain
• Headache, dizziness, drowsiness
• Flatulence
• Genital infections, urinary tract infection, increased or more frequent urination
• Nasal congestion, sore throat, upper respiratory tract infection, common cold, influenza, cough
• Itching, dry mouth, thirst
• Decreased weight

Serious Side Effects (Consult your doctor immediately if you experience):

• Symptoms of acute pancreatitis, such as severe and persistent abdominal pain that might radiate to your back, with or without nausea and vomiting.
• Symptoms of allergic reactions like rash, hives, blisters on the skin, peeling skin, and swelling of the face, lips, tongue, and throat that may cause difficulty breathing or swallowing.
• Signs of bullous pemphigoid (blistering of the skin).
• Signs of lactic acidosis, such as weakness, breathing difficulty, or stomach pain.
• Symptoms of ketoacidosis, including nausea, vomiting, confusion, or fruity breath.

Precautions

• SITARED MD XR 500 is generally not recommended for use during pregnancy or in breastfeeding women. Consult your doctor if you are pregnant or breastfeeding.
• This medicine is not suitable for use if you have respiratory failure, severe kidney disease, liver disease, heart failure, or a recent myocardial infarction.
• Avoid excessive alcohol intake while taking this medicine as it increases the risk of hypoglycemia and lactic acidosis.
• Inform your doctor about your complete medical history and all medications you are taking, including herbs and supplements, to prevent unwanted effects.
• Regular monitoring of blood sugar levels is essential during treatment.
• Maintain good hygiene to help prevent genital fungal infections.
• Drinking plenty of fluids helps prevent dehydration.
• Use with caution if you have kidney or liver problems, a urinary tract infection, or are on diuretics.
• It is not recommended for use in children below 18 years of age.
• This medicine may decrease alertness, affect vision, or cause sleepiness and dizziness; therefore, caution is advised when driving or operating machinery.
• Inform your doctor or dentist if you are scheduled for an operation, dental work, or any X-ray procedure involving a dye, as you may need to stop Metformin temporarily.

Storage Store SITARED MD XR 500 Tablet at a consistent temperature below 30°C. Keep the medicine in a cool and dry place, away from moisture and direct sunlight. Always place the medicine out of the sight and reach of children.

Here are some frequently asked questions about Sitared MD XR 500:

What is Sitared MD XR 500 used for?

Sitared MD XR 500 Tablet is an antidiabetic medicine primarily used to manage blood sugar levels in adults with Type 2 Diabetes Mellitus. It is used as an adjunct to diet and exercise when metformin alone or dual therapy is insufficient. Beyond blood sugar control, it also helps lower the risk of heart failure and diabetic kidney disease, and can support weight loss and improve metabolic health.

How does Sitared MD XR 500 work?

Sitared MD XR 500 is a combination of three active ingredients: Dapagliflozin, Sitagliptin, and Metformin.

• Dapagliflozin works by decreasing the reabsorption of glucose in the kidneys, leading to more glucose being excreted through the urine, thereby reducing blood glucose levels.
• Sitagliptin increases the levels of natural substances called incretins, which stimulate the pancreas to release more insulin when blood sugar is high and signal the liver to reduce sugar production.
• Metformin decreases glucose production by the liver, delays glucose absorption from the intestines, and enhances the body's sensitivity to insulin. These combined actions provide multi-targeted control of blood sugar levels.

What is the usual dosage of Sitared MD XR 500?

The dosage of Sitared MD XR 500 is determined by your doctor based on your individual condition and needs. It should be taken exactly as prescribed. The tablet can be taken with or without food, but taking it consistently at the same time each day is recommended for optimal benefits. Do not crush or chew the tablet, and do not stop taking the medicine without consulting your doctor, as this can lead to increased blood sugar levels and potential complications.

What are the possible side effects of Sitared MD XR 500?

Common side effects of Sitared MD XR 500 include urinary tract infections, genital infections, nasal congestion, sore throat, upper respiratory tract infections, nausea, vomiting, abdominal pain, headache, and flatulence. Serious but rare side effects that require immediate medical attention include symptoms of lactic acidosis (weakness, difficulty breathing, stomach pain), ketoacidosis (nausea, vomiting, confusion, fruity breath), acute pancreatitis (severe, persistent abdominal pain), or severe allergic reactions (rash, swelling of face/lips/tongue, difficulty breathing).

Is Sitared MD XR 500 safe during pregnancy or breastfeeding?

Sitared MD XR 500 is generally not recommended for use during pregnancy or while breastfeeding due to limited information on its effects and potential risks. If you are pregnant, planning pregnancy, or breastfeeding, inform your doctor before taking this medicine.

Can Sitared MD XR 500 be taken with other medications?

Sitared MD XR 500 can interact with other medications. It is crucial to inform your doctor about all prescription, non-prescription, herbal supplements, and other medicines you are taking.

• Diuretics (water pills) such as furosemide or hydrochlorothiazide can increase the risk of dehydration and low blood pressure.
• Taking it with insulin or insulin secretagogues (like sulfonylureas) may increase the risk of hypoglycemia (very low blood sugar).
• Caution should be exercised with certain antifungal medications (e.g., ketoconazole, itraconazole), antibacterial medications (e.g., clarithromycin), antivirals (e.g., ritonavir), and corticosteroids.
• Medicines for heart failure like digoxin also require caution.

What precautions should be taken?

Several precautions should be observed while taking Sitared MD XR 500:

• Alcohol consumption should be avoided or limited as it can increase the risk of hypoglycemia and lactic acidosis.
• The medicine is not recommended for patients with severe liver or kidney disease, heart failure, Type 1 diabetes, or diabetic ketoacidosis.
• Inform your doctor if you are scheduled for surgery, dental work, or an X-ray procedure involving a dye injection, as you may need to temporarily stop this medicine.
• Regular monitoring of blood sugar levels and kidney function is crucial during treatment.
• Maintain good hygiene to help prevent genital fungal infections.
• If you experience symptoms like nausea, vomiting, abdominal pain, excessive thirst, confusion, sleepiness, or tiredness, contact your doctor immediately as these could indicate serious conditions like lactic acidosis.

What happens if a dose is missed?

If you miss a dose of Sitared MD XR 500, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to compensate for the missed one.

How should it be stored?

Sitared MD XR 500 Tablet should be stored in a cool and dry place, away from direct sunlight. Keep the medicine out of the sight and reach of children. It should be stored at temperatures below 30°C.