Perlice Cream 120 G

PERLICE CREAM 120 G

Perlice Cream 120 G is a topical medication manufactured by Curatio Healthcare Pvt Ltd, primarily used to treat parasitic infestations of the skin and hair.

• Name:

  • Brand Name: Perlice Cream, Perlice Permethrin Cream, Perlice Rinse Cream
  • Common Name: Permethrin Cream

• Composition:

  • Active Ingredient: Permethrin (10 mg/g or 1%)
  • Preservatives: Methyl Paraben IP (2.0 mg/g), Propyl Paraben IP (0.8 mg/g)
  • Excipients: Cetyl Alcohol, Citric Acid, Canada Balsam, Forestall, Sunset Yellow, Hydroxyethyl Cellulose, Isopropyl Alcohol, P-Collagen, Silver Moon Perfume, and Sodium Hydroxide

• Uses: Perlice Cream belongs to the class of medications called scabicides and pediculicides, used to eliminate parasites responsible for various conditions.

  • Scabies: Treats skin infestations caused by tiny mites that burrow into the skin, leading to intense itching and a rash. It works by paralyzing and killing the mites and their eggs.
  • Head Lice (Pediculosis Capitis): Effectively removes lice and nits (eggs) from hair and scalp. It works by disrupting the nerve cell function of lice and their eggs, leading to their death.

• Dosage and Administration: Perlice Cream is for external use only and should be used as advised by a doctor.

  • For Head Lice:
    • Apply evenly on washed, towel-dried hair from root to tip.
    • Leave on for 10-15 minutes, then wash off with warm water.
    • Use a fine-toothed comb to remove nits and dead lice.
    • A second application may be needed after at least 7 days if live lice are still observed.
  • For Scabies:
    • Thoroughly massage the cream into the skin from the head to the soles of the feet (excluding the face and scalp in adults, but including them in infants and geriatric patients if infested).
    • Leave on for approximately 8 to 14 hours (or 8-12 hours) before washing off with soap and water.
    • Usually, one application is sufficient, but a second application may be required after 7 days if the condition persists.

• Side Effects: Common side effects are usually mild and may resolve over time.

  • Common: Redness, rash, itching, burning or stinging sensation, numbness, or tingling at the application site.
  • Serious: Rare, but severe allergic reactions may occur (e.g., skin rash, swelling of face/tongue/throat, severe dizziness, breathing difficulty). Seek immediate medical attention if these occur.

• Precautions:

  • Allergies: Do not use if allergic to Permethrin, other pyrethrins, chrysanthemums, or any components of the cream.
  • External Use Only: Strictly for external use.
  • Avoid Contact: Avoid contact with eyes, nose, mouth, mucous membranes, eyelashes, eyebrows, or broken skin. Rinse thoroughly with water if accidental contact occurs.
  • Children: Not recommended for children younger than 2 months of age. Consult a doctor for children older than 2 months or below six years.
  • Pregnancy and Breastfeeding: Generally considered safe if prescribed by a doctor, but consultation is advised due to limited human studies.
  • Other Conditions: Use with caution in patients with asthma, eczema, or other skin infections. Inform your doctor about any underlying medical conditions, allergies, or other medications, supplements, or herbal products being taken.
  • Itching after Treatment: Itching may persist for a few weeks after treatment, which is often an allergic reaction to dead mites and does not necessarily indicate treatment failure.

• Storage:

  • Store in a cool and dry place, away from direct sunlight.
  • Keep out of the sight and reach of children.
  • Do not store above 30°C (or between 10ºC to 25ºC, or below 25°C). Do not freeze.

What is Perlice Cream used for?

Perlice Cream, which contains permethrin, is primarily used to treat infestations of scabies and head lice. Scabies is a skin condition caused by tiny mites that burrow into the skin, leading to intense itching and a rash. Head lice are small insects that infest the scalp and hair, causing itchiness and discomfort. It can also be used to manage other parasitic infections.

How does Perlice Cream work?

Perlice Cream's active ingredient, permethrin, is a synthetic pyrethroid pesticide. It works by targeting and disrupting the nervous system of mites and lice, causing paralysis and ultimately killing them and their eggs (nits). Permethrin is poorly absorbed through the skin, with less than 0.5% absorbed during the first 48 hours, and rapidly metabolized to inactive compounds that are excreted in urine.

What is the usual dosage and application?

For treating scabies, adults and children over 2 months of age should thoroughly massage the cream into all skin surfaces from the head to the soles of the feet. This includes areas like between fingers and toes, under fingernails, and in skin folds. For infants and elderly patients, the hairline, neck, temples, and forehead should also be treated. The cream should be left on for 8 to 14 hours, then washed off by bathing or showering. A single application is often sufficient, but a second treatment may be necessary if live mites are observed 14 days or more after the initial application.

For treating head lice, for adults and children 2 months of age and older, the cream (often a 1% formulation) is typically applied to shampooed, towel-dried hair and scalp, ensuring saturation, especially behind the ears and on the nape of the neck. It is usually left on for 10 minutes, then rinsed off. A fine-toothed comb should be used to remove dead lice and nits. Reapplication may be needed after 7 days if live lice are still present.

What are the possible side effects?

Common side effects of Perlice Cream may include mild burning, stinging, itching, redness, dryness, or a mild rash at the application site. It's not uncommon for itching and rash to persist for 2 to 4 weeks after treatment, which is usually a temporary reaction to the dead mites and does not mean the treatment failed. Severe allergic reactions, such as hives, difficulty breathing, or swelling of the face, lips, tongue, or throat, are rare but require immediate medical attention.

Is it safe during pregnancy or breastfeeding?

Permethrin is generally considered safe for use during pregnancy and breastfeeding. It has low systemic absorption, meaning very little of the medication enters the bloodstream, and it is rapidly metabolized. The CDC and other guidelines recommend permethrin as a first-choice treatment for scabies and lice in pregnant and lactating women. However, it is always advisable to consult a doctor before use if pregnant or breastfeeding. If breastfeeding, the cream should be removed from the nipple area before feeding and reapplied afterward.

Can it be taken with other medications?

Interactions with other orally taken or injected medications are generally not expected with topical permethrin. However, it is recommended to avoid using other skin products on the affected area without consulting a healthcare provider. Corticosteroids (steroids) should not be used to treat skin conditions like eczema concurrently with permethrin cream for scabies or lice, as they may worsen the infestation.

What precautions should be taken?

Perlice Cream is for external use only; do not swallow it. Avoid contact with eyes, nose, mouth, or other mucous membranes. If accidental contact occurs, rinse thoroughly with plenty of cool water. It may worsen symptoms of asthma or eczema. If you are allergic to permethrin, chrysanthemums, or other pyrethroids, you should not use this cream. Children under 2 months of age should only be treated under close medical supervision. Carers applying the cream should wear gloves. Also, avoid smoking or going near naked flames as fabric in contact with the product can burn more easily.

What happens if a dose is missed?

Since Perlice Cream is typically a single or two-application treatment, the concept of a "missed dose" as with daily medications usually doesn't apply. If you forget to apply it as directed, apply it as soon as you remember. However, do not apply a double quantity to make up for a forgotten application. If live mites are still observed after the recommended interval (e.g., 14 days for scabies, 7 days for head lice), consult your doctor, as a repeat treatment might be necessary.

How should it be stored?

Perlice Cream should be stored in a cool, dry place, away from direct sunlight, and kept out of the reach of children. It is generally advised to store it below 30°C. Do not flush medications down the toilet or pour them into a drain; consult your pharmacist or local waste disposal company for proper disposal of expired or unused product.