Endobloc 5 Mg Tablet (10 Tab)

ENDOBLOC 5 MG TABLET

ENDOBLOC 5 MG TABLET, manufactured by Cipla Ltd., is a medication primarily used for the management of pulmonary arterial hypertension (PAH).

Name

• Brand Name: ENDOBLOC 5 MG TABLET
• Common Name: Ambrisentan Tablets

Composition

• Active Ingredient: Ambrisentan 5 mg

Uses ENDOBLOC 5 MG TABLET is prescribed for the treatment of pulmonary arterial hypertension (PAH). PAH is a condition characterized by high blood pressure in the arteries that carry blood from the heart to the lungs. The medication works by relaxing and widening the blood vessels in the lungs, which helps improve blood flow and reduces the strain on the heart. It is used to improve exercise capacity, enhance quality of life, and delay disease progression in individuals with PAH. It can be used as a monotherapy or in combination with other PAH medications.

Dosage and Administration

• ENDOBLOC 5 MG TABLET is typically taken orally once daily, with or without food.
• It is important to follow the prescribed dosage from your healthcare provider and take the medication at the same time each day to maintain consistent levels in your system.
• The tablet should be swallowed whole with water and should not be crushed or chewed.
• The typical starting dose is 5 mg once daily, which may be increased to 10 mg based on patient response and tolerability.

Side Effects Common side effects may include:

• Peripheral edema (swelling of the limbs)
• Headache
• Flushing (sense of warmth in the face, ears, neck, and trunk)
• Nasal congestion (stuffy nose)
• Nausea
• Stomach pain/upset
• Dizziness
• Tiredness/fatigue

Serious side effects can include:

• Liver problems, including an increase in liver enzyme levels, liver toxicity, and rarely, liver failure or autoimmune hepatitis.
• Anemia (low red blood cell count)
• Fluid retention, potentially leading to worsening heart failure symptoms.
• Potential birth defects if taken during pregnancy.
• Decreased white blood cell count.
• Severe hypotension (low blood pressure)
• Pulmonary edema (rare)

Precautions

• Pregnancy: ENDOBLOC 5 MG TABLET is highly unsafe and contraindicated during pregnancy due to the risk of severe birth defects. Women of childbearing potential must have a negative pregnancy test before starting treatment and use two reliable methods of contraception during treatment and for one month after stopping the medication.
• Liver Disease: Use with caution in patients with liver disease. Regular monitoring of liver function tests is essential. It is not recommended for use in severe liver conditions.
• Heart Failure: Close monitoring for fluid retention is crucial, especially in individuals with a history of heart failure, as it can worsen symptoms.
• Anemia: Regular blood tests are required to monitor for decreases in red blood cell count.
• Kidney Disease: Use with caution in patients with severe kidney disease.
• Grapefruit Juice: Avoid consuming grapefruit juice as it can increase the levels of Ambrisentan in the body, potentially leading to an increased risk of side effects.
• Drug Interactions: Inform your healthcare provider about all medications and supplements you are taking, as Ambrisentan may interact with other drugs, particularly immunosuppressants like cyclosporine.
• Driving and Operating Machinery: This medication may cause dizziness, low blood pressure, or tiredness. Avoid driving or performing activities that require mental focus until you understand how ENDOBLOC 5 MG TABLET affects you.
• Children and Elderly: Not recommended for use in children. Use with caution in elderly patients.
• Breastfeeding: Consult your doctor before using during breastfeeding as information on its safety is limited or not available.

Storage

• Store at room temperature, between 20°C to 25°C (68°F to 77°F).
• Keep away from moisture, heat, and direct light.
• It should not be frozen.
• Keep out of reach of children and pets.

Here are the frequently asked questions about ENDOBLOC 5 MG TABLET, containing Ambrisentan 5 mg:

What is ENDOBLOC 5 MG TABLET used for?

ENDOBLOC 5 MG TABLET is primarily used to treat Pulmonary Arterial Hypertension (PAH) in adults. PAH is a condition characterized by high blood pressure in the arteries that carry blood from the heart to the lungs. This medication helps to relax and widen the blood vessels in the lungs, which improves blood flow and reduces the workload on the heart. It can enhance exercise capacity, alleviate symptoms like shortness of breath and fatigue, and delay the progression of the disease.

How does ENDOBLOC 5 MG TABLET work?

ENDOBLOC 5 MG TABLET contains Ambrisentan, which is an endothelin receptor antagonist (ERA). It works by blocking the action of endothelin-1, a natural substance in the body that causes blood vessels, particularly those in the lungs, to narrow and constrict. By inhibiting endothelin's effects, Ambrisentan promotes vasodilation (widening of blood vessels), thereby reducing the resistance to blood flow and lowering the blood pressure in the pulmonary arteries.

What is the usual dosage of ENDOBLOC 5 MG TABLET?

The usual recommended dosage of ENDOBLOC 5 MG TABLET for adults is 5 mg once daily, taken orally. The tablet should be swallowed whole with water and not crushed, broken, or chewed. It can be taken with or without food. Your doctor will determine the appropriate dose and duration of treatment based on your medical condition.

What are the possible side effects of ENDOBLOC 5 MG TABLET?

Common side effects may include headache, flushing, stomach upset, nasal congestion, nausea, dyspepsia, muscle pain, back pain, and pain in extremities. More serious side effects can include decreased red blood cell counts (anemia), fluid retention (oedema or swelling, especially in the ankles and feet), and potential liver problems. Signs of liver problems may include dark urine, yellowing of the skin or eyes (jaundice), persistent nausea or vomiting, loss of appetite, and upper stomach pain. If you experience any severe or persistent side effects, or signs of liver problems or significant fluid retention, you should consult your doctor immediately.

Is ENDOBLOC 5 MG TABLET safe during pregnancy or breastfeeding?

No, ENDOBLOC 5 MG TABLET is not safe during pregnancy and is contraindicated. Ambrisentan may cause serious birth defects or harm to an unborn baby. Females of reproductive potential must have a negative pregnancy test before starting treatment, monthly during treatment, and for at least one month after stopping the medication. They must also use two effective methods of contraception throughout this period. It is also advised not to breastfeed during treatment with ENDOBLOC 5 MG TABLET due to the potential for serious adverse reactions in breastfed infants. Consult your doctor if you are breastfeeding.

Can ENDOBLOC 5 MG TABLET be taken with other medications?

ENDOBLOC 5 MG TABLET can interact with various medications, affecting their effectiveness or increasing the risk of side effects. It is crucial to inform your doctor about all prescription and over-the-counter medications, supplements, traditional medicines, and herbal remedies you are taking. For instance, strong inhibitors or inducers of certain liver enzymes (like CYP3A4, e.g., ketoconazole, rifampin, ritonavir) can significantly alter the levels of Ambrisentan in your body. Also, consuming grapefruit or grapefruit juice should be avoided as it can increase the levels of this medication, potentially leading to increased side effects.

What precautions should be taken while using ENDOBLOC 5 MG TABLET?

Inform your doctor about any pre-existing medical conditions, especially heart failure, liver or kidney diseases, lung conditions (such as pulmonary fibrosis or pulmonary veno-occlusive disease), anemia, or low blood pressure. Regular blood tests will be required before and during treatment to monitor for anemia and to assess liver function. Do not stop taking the medication without consulting your doctor, as sudden discontinuation can worsen your condition. This medicine may cause dizziness or weakness, so exercise caution when driving or operating machinery until you know how it affects you.

What happens if a dose of ENDOBLOC 5 MG TABLET is missed?

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take two doses at the same time to make up for a missed dose.

How should ENDOBLOC 5 MG TABLET be stored?

ENDOBLOC 5 MG TABLET should be stored in a closed container at room temperature, away from excessive heat, moisture, and direct light. Keep this medicine out of the reach of children and pets.