Neptaz 100 Mg Tablet (14 Tab)

NEPTAZ 100 MG TABLET

Name

Brand Name: Neptaz 100 mg Tablet Common Name: Sacubitril and Valsartan tablets

Composition

Neptaz 100 mg Tablet is a combination medicine containing two active ingredients:

• Sacubitril (49 mg)
• Valsartan (51 mg)

This combination belongs to a class of drugs known as angiotensin receptor neprilysin inhibitors (ARNI). Sacubitril works by inhibiting neprilysin, an enzyme that breaks down natriuretic peptides, which help relax blood vessels and reduce strain on the heart. Valsartan is an angiotensin receptor blocker (ARB) that blocks the action of angiotensin II, leading to relaxed and widened blood vessels.

Uses

Neptaz 100 mg Tablet is primarily used for the treatment of heart failure in adults, particularly those with chronic heart failure and reduced ejection fraction. It helps to reduce the risk of hospitalization and death in such patients by improving the heart's ability to pump blood effectively. The medicine helps to manage symptoms like breathlessness, tiredness, and swelling in the legs.

Dosage and Administration

This medicine should be taken as prescribed by your doctor. It can be taken with or without food, but it is advisable to take it at the same time each day for maximum benefit. Do not chew, crush, or break the tablet; swallow it whole with a glass of water. Do not exceed the recommended dose.

Side Effects

Common side effects may include:

• Dizziness, light-headedness, or fainting (due to low blood pressure)
• Cough
• Nausea, stomach pain, or diarrhea
• Weakness or fatigue
• Headache
• Increased potassium levels in the blood (hyperkalemia)
• Impaired renal function

Serious side effects that require immediate medical attention include severe allergic reactions such as angioedema (swelling of the face, lips, tongue, or throat, causing difficulty in breathing or swallowing).

Precautions

• Allergies: Do not take Neptaz 100 mg Tablet if you are allergic to Sacubitril, Valsartan, or any of its components.
• Drug Interactions:
  • Avoid taking with ACE inhibitors (e.g., captopril, enalapril) as it can increase the risk of side effects, including angioedema. A washout period of at least 36 hours is required before or after taking an ACE inhibitor.
  • Inform your doctor if you are taking potassium-sparing diuretics or potassium supplements, as this can further increase potassium levels in the blood.
  • Caution is advised with other blood pressure medications, lithium, and NSAIDs.
• Medical Conditions: Inform your doctor if you have kidney or liver diseases, diabetes, or a history of angioedema.
• Pregnancy and Breastfeeding: Neptaz 100 mg Tablet is not recommended during pregnancy or breastfeeding.
• Driving and Machinery: This medicine may cause dizziness, so avoid driving or operating heavy machinery if you experience this side effect. Rise slowly from sitting or lying positions to prevent dizziness.
• Monitoring: Regular monitoring of blood pressure, kidney function, and potassium levels is recommended.

Storage

Store Neptaz 100 mg Tablet in a cool and dry place, away from direct sunlight. Keep it out of the sight and reach of children. Store in its original package to protect it from moisture and light. The recommended storage temperature is between 10ºC to 25ºC or below 30ºC.

What is NEPTAZ 100 MG Tablet used for?

NEPTAZ 100 MG Tablet is primarily used to treat chronic heart failure in adults, particularly those with reduced ejection fraction. It helps to reduce the risk of hospitalization and cardiovascular death associated with this condition.

How does NEPTAZ 100 MG Tablet work?

NEPTAZ 100 MG Tablet is a combination of two medicines: sacubitril and valsartan, which belong to a class called angiotensin receptor neprilysin inhibitors (ARNI). Sacubitril works by inhibiting an enzyme called neprilysin, which increases the levels of natural substances (natriuretic peptides) that help relax blood vessels, eliminate excess sodium and water, and reduce strain on the heart. Valsartan blocks the action of angiotensin II, a hormone that causes blood vessels to narrow. Together, these actions relax and widen blood vessels, making it easier for the heart to pump blood throughout the body and improving overall heart function.

What is the usual dosage for NEPTAZ 100 MG Tablet?

The dosage of NEPTAZ 100 MG Tablet is determined by your doctor based on your medical condition and response to treatment. It should be taken exactly as prescribed, typically with or without food, at the same time each day for maximum benefit. It is important not to chew, crush, or break the tablet; swallow it whole with a glass of water. Do not stop taking the medicine even if you feel well, as it helps prevent future complications.

What are the possible side effects of NEPTAZ 100 MG Tablet?

Common side effects of NEPTAZ 100 MG Tablet can include dizziness, light-headedness (due to low blood pressure), cough, nausea, fatigue, headache, diarrhea, and weakness. Other potential side effects may include high potassium levels in the blood (hyperkalemia) and impaired kidney function. If you experience severe or persistent side effects, it's advisable to consult your doctor.

Is NEPTAZ 100 MG Tablet safe during pregnancy or breastfeeding?

NEPTAZ 100 MG Tablet is not recommended for use during pregnancy, especially after the first three months, as it can harm the unborn baby. If you become pregnant while taking this medicine, stop use and contact your doctor immediately. It is also generally not recommended for breastfeeding mothers, as limited data suggests it may pass into breast milk and potentially harm the baby. Your doctor will weigh the potential risks and benefits in specific situations.

Can NEPTAZ 100 MG Tablet be taken with other medications?

NEPTAZ 100 MG Tablet can interact with several other medications. It should not be taken with ACE inhibitors (such as enalapril or lisinopril), and there should be at least a 36-hour gap before or after taking an ACE inhibitor. Concomitant use with aliskiren (especially in patients with diabetes or kidney disease), potassium-sparing diuretics, potassium supplements, and NSAIDs (painkillers) should be avoided or used with caution due to increased risks of low blood pressure, high potassium levels, or worsening kidney function. Inform your doctor about all medications, herbal preparations, and supplements you are currently taking to prevent potential drug interactions.

What precautions should be taken while using NEPTAZ 100 MG Tablet?

Several precautions should be taken while using NEPTAZ 100 MG Tablet. Inform your doctor if you have kidney or liver disease, a history of hereditary angioedema (rapid swelling under the skin), or low blood pressure. To reduce the risk of dizziness from low blood pressure, rise slowly when moving from a sitting or lying position. Alcohol consumption is advised with caution as it may increase dizziness. Regular monitoring of blood pressure, kidney function, and potassium levels may be advised by your doctor.

What happens if a dose of NEPTAZ 100 MG Tablet is missed?

If you miss a dose of NEPTAZ 100 MG Tablet, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a forgotten tablet.

How should NEPTAZ 100 MG Tablet be stored?

NEPTAZ 100 MG Tablet should be stored in a cool and dry place, away from direct sunlight, at room temperature (typically below 30°C or between 10°C and 25°C). Keep the medicine in its original package to protect it from moisture and light, and always keep it out of the sight and reach of children and pets.