Sitabless M 50/500 Tab

SITABLESS M 50/500 Tablet

Name:

• Brand Name: SITABLESS M 50/500 Tablet
• Manufacturer: Mankind Pharma Ltd.

Composition: Each film-coated tablet contains:

• Sitagliptin: 50 mg
• Metformin: 500 mg

Uses: SITABLESS M 50/500 Tablet is a prescription medication primarily used to manage Type 2 Diabetes Mellitus in adults. It is an adjunct to diet and exercise to improve glycemic control. The combination of sitagliptin and metformin works by enhancing insulin release from the pancreas, improving the body's sensitivity to insulin, reducing glucose production in the liver, and decreasing sugar absorption from the intestines. This helps to control high blood sugar levels and prevent serious complications of diabetes such as kidney damage, nerve damage, blindness, and cardiovascular risks like heart attack and stroke.

Dosage and Administration: The typical starting dose for adults is one tablet once or twice a day, preferably taken with meals. The dosage may be adjusted by a doctor based on blood sugar levels and individual needs, with a maximum dose generally not exceeding two tablets per day. Tablets should be swallowed whole with a glass of water and not crushed or chewed. It is important to take the medicine regularly, at the same time each day, as prescribed by the doctor.

Side Effects:

• Common Side Effects: Nausea, diarrhea, stomach discomfort, flatulence, constipation, headache, dry mouth, upper respiratory tract infection, stuffy or runny nose, sore throat, and weakness. Hypoglycemia (low blood sugar) can occur, especially if taken with other diabetes medicines.
• Serious Side Effects: Lactic acidosis is a rare but serious side effect, particularly associated with Metformin, and symptoms can include muscle pain or weakness, dizziness, difficulty breathing, nausea, vomiting, and stomach pain.

Precautions: Inform your doctor if you have liver or kidney problems, severe dehydration, or Type 1 diabetes. SITABLESS M 50/500 Tablet is generally contraindicated during pregnancy and breastfeeding. Caution is advised for elderly patients and those with heart disease. Alcohol consumption should be limited or avoided as it can increase the risk of lactic acidosis and hypoglycemia. Regular monitoring of kidney function and blood sugar levels is recommended during treatment.

Storage: Store the medicine in a cool, dry place at room temperature, not exceeding 30°C. Protect it from light and moisture, and always keep it out of reach of children.

Here are some frequently asked questions about SITABLESS M 50/500 Tablet:

What is SITABLESS M 50/500 Tablet used for?

SITABLESS M 50/500 Tablet is a prescription medication used to manage type 2 diabetes mellitus in adults. It helps to lower high blood sugar levels, which in turn can help prevent serious complications of diabetes such as kidney damage, nerve damage, blindness, and cardiovascular risks like heart attack and stroke. It is typically used alongside a proper diet and regular exercise.

How does SITABLESS M 50/500 Tablet work?

This medicine combines two active ingredients: Sitagliptin (50mg) and Metformin (500mg). Sitagliptin is a DPP-4 inhibitor that works by increasing the body's natural insulin release, especially after meals, and reducing the amount of sugar produced by the liver. Metformin, a biguanide, reduces glucose production in the liver, decreases the absorption of glucose from the intestines, and improves the body's sensitivity to insulin. Together, these actions lead to better control of blood sugar levels.

What is the usual dosage for SITABLESS M 50/500 Tablet?

The typical starting dose for adults not currently taking metformin is one tablet (50 mg sitagliptin/500 mg metformin HCl) twice daily with meals. For patients already on metformin, the dosage of sitagliptin will be 50 mg twice daily, maintaining their current metformin dose. The maximum recommended daily dose is 100 mg of sitagliptin and 2000 mg of metformin HCl. Dosage adjustments are made by a doctor based on blood sugar levels and individual needs, and it is usually taken with meals to reduce gastrointestinal side effects.

What are the possible side effects of SITABLESS M 50/500 Tablet?

Common side effects include nausea, stomach discomfort, gas (flatulence), diarrhea, constipation, headache, upper respiratory tract infection, and dry mouth. Low blood sugar (hypoglycemia) can occur, especially if taken with other diabetes medications like insulin or sulfonylureas. A rare but serious side effect is lactic acidosis, which is an excess of lactic acid in the blood and can be a medical emergency. Long-term use may also lead to vitamin B12 deficiency.

Is SITABLESS M 50/500 Tablet safe during pregnancy or breastfeeding?

SITABLESS M 50/500 Tablet is generally contraindicated during pregnancy and breastfeeding. It is not recommended for use in pregnant women unless explicitly prescribed by a doctor, due to potential risks to the growing baby. For breastfeeding women, metformin can pass into breast milk in small amounts, and there is limited data on sitagliptin's presence, so it should be used only if the benefits outweigh the risks, and after consulting a doctor.

Can SITABLESS M 50/500 Tablet be taken with other medications?

Yes, it can be taken with other diabetes medications, including insulin and sulfonylureas, but dose adjustments may be needed to avoid low blood sugar. Certain medications can interact with SITABLESS M 50/500 Tablet, such as diuretics (e.g., furosemide, hydrochlorothiazide), ACE inhibitors (e.g., lisinopril), and corticosteroids (e.g., prednisone), potentially affecting blood sugar levels or increasing the risk of side effects like lactic acidosis. It is crucial to inform your doctor about all medications you are taking, including herbal supplements.

What precautions should be taken while using SITABLESS M 50/500 Tablet?

Before taking this medicine, inform your doctor if you have liver or kidney problems, severe dehydration, or type 1 diabetes. It should be used with caution in elderly patients and those with a history of pancreatitis. Excessive alcohol consumption should be avoided as it can increase the risk of lactic acidosis. Regular monitoring of kidney and liver function is advised during long-term use.

What happens if a dose of SITABLESS M 50/500 Tablet is missed?

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take two doses at once or an extra dose to make up for a missed one.

How should SITABLESS M 50/500 Tablet be stored?

SITABLESS M 50/500 Tablet should be stored in a cool, dry place at room temperature, not exceeding 30°C. Keep it away from direct sunlight, moisture, and out of the sight and reach of children.