Rosuvas 40 Mg Tablet (10 Tab)

ROSUVAS 40 MG TABLET

Name:

• Brand Name: ROSUVAS 40 MG TABLET
• Common Name: Rosuvastatin (as rosuvastatin calcium)

Composition: Each tablet contains 40 mg of Rosuvastatin as its active ingredient. Inactive ingredients may include lactose monohydrate, microcrystalline cellulose, crospovidone, magnesium stearate, sodium citrate, hypromellose, titanium dioxide, and macrogol 400.

Uses: ROSUVAS 40 MG TABLET is a statin medication primarily used to lower elevated levels of "bad" cholesterol (LDL-C) and triglycerides in the blood, while simultaneously increasing "good" cholesterol (HDL-C). It is prescribed to reduce the risk of heart disease, heart attacks, and strokes by preventing the buildup of fatty deposits in arteries (atherosclerosis). It is also used in the management of primary hyperlipidemia, mixed dyslipidemia, hypertriglyceridemia, primary dysbetalipoproteinemia, and familial hypercholesterolemia.

Dosage and Administration: The typical adult dosage range is 5 mg to 40 mg, taken once daily. The 40 mg dose is generally reserved for patients who have not achieved their LDL-C goal with a 20 mg dose or those with severe hypercholesterolemia and high cardiovascular risk. Tablets can be taken at any time of day, with or without food, and should be swallowed whole with water. Dose adjustments are usually made at intervals of four weeks or more. Rosuvas 40 mg tablet is not suitable for use in children.

Side Effects:

• Common: Headache, stomach pain, nausea, constipation, muscle pain, weakness, dizziness, and protein in urine. There is also an increased risk of developing diabetes, especially in individuals with pre-existing risk factors.
• Serious (Rare): Severe allergic reactions (including swelling of the face, lips, tongue, or throat, and difficulty breathing or swallowing), muscle damage (myopathy or rhabdomyolysis) which may present as unexplained muscle pain, tenderness, or weakness, dark-colored urine, and fever. Liver problems (e.g., yellowing of skin/eyes, dark urine, persistent nausea, stomach pain) and severe stomach pain (pancreatitis) are also rare but serious side effects.

Precautions: ROSUVAS 40 MG TABLET is contraindicated in pregnant or breastfeeding women, and individuals with active liver disease or allergies to rosuvastatin. Caution is advised in patients with kidney disease, hypothyroidism, and a history of muscle problems. Regular alcohol consumption should be moderated as it can increase the risk of liver problems. Patients of Asian origin may have increased exposure to rosuvastatin and may require a lower starting dose. Interactions can occur with medicines like cyclosporine, gemfibrozil, fusidic acid, and certain antivirals, necessitating dose adjustments or avoidance. Regular monitoring of cholesterol and liver function is recommended during treatment.

Storage: Store the medicine in its blister pack at room temperature, ideally between 20°C to 25°C or below 30°C. Keep away from heat, moisture, direct light, and out of the reach of children. Do not freeze.

What is ROSUVAS 40 MG TABLET used for?

ROSUVAS 40 MG TABLET, which contains the active ingredient rosuvastatin, is primarily used to lower high cholesterol and triglyceride levels in the blood. It helps to reduce "bad" cholesterol (LDL) and triglycerides while increasing "good" cholesterol (HDL). By doing so, it significantly reduces the risk of serious cardiovascular events such as heart attacks and strokes, and can slow the progression of atherosclerosis (hardening of the arteries).

How does ROSUVAS 40 MG TABLET work?

ROSUVAS 40 MG TABLET belongs to a class of medicines called statins. It works by blocking an enzyme in the liver known as HMG-CoA reductase, which is essential for cholesterol production in the body. By inhibiting this enzyme, the medication reduces the production of "bad" cholesterol (LDL) and improves the body's ability to remove existing cholesterol from the bloodstream.

What is the usual dosage for ROSUVAS 40 MG TABLET?

For adults, the dosage range for rosuvastatin is typically 5 mg to 40 mg orally once daily. The usual starting dose is often 10 mg or 20 mg once a day. The 40 mg dose is generally reserved for patients who have not achieved their LDL cholesterol goals with a 20 mg dose and are at a high risk of heart attacks or strokes. Your doctor will determine the most appropriate dose for your specific condition and may adjust it based on your cholesterol levels, which are usually checked every 4 weeks after starting or adjusting the medication. The tablet should be swallowed whole with water, and can be taken at any time of day, with or without food.

What are the possible side effects of ROSUVAS 40 MG TABLET?

Common side effects may include headache, stomach pain, constipation, nausea, muscle pain, feeling weak, and dizziness.

More serious, though rare, side effects can occur. These include unexplained muscle pain, tenderness, or weakness, especially if accompanied by fever or unusual tiredness, which could indicate serious muscle problems like myopathy or rhabdomyolysis, potentially leading to kidney damage. Liver problems are also a serious, rare side effect, indicated by symptoms such as unusual tiredness, dark urine, pale stools, severe stomach pain, or yellowing of the eyes or skin (jaundice). If you experience any severe or persistent side effects, or signs of liver or muscle problems, contact your doctor immediately.

Is ROSUVAS 40 MG TABLET safe during pregnancy or breastfeeding?

ROSUVAS 40 MG TABLET (rosuvastatin) is generally not recommended during pregnancy and is considered unsafe. If you become pregnant while taking this medicine, you should stop taking it and inform your doctor right away, as it may harm the unborn baby. Women of childbearing potential should use effective birth control while on this medication.

Regarding breastfeeding, ROSUVAS 40 MG TABLET is also considered unsafe. Small amounts of rosuvastatin may pass into breast milk and could potentially affect the baby's lipid metabolism. It's advised not to breastfeed while using this medication, and you should discuss the best way to feed your baby with your doctor.

Can ROSUVAS 40 MG TABLET be taken with other medications?

Yes, but it's crucial to inform your doctor about all other medications, supplements, or herbal remedies you are taking, as rosuvastatin can interact with certain drugs. For example, taking antacids containing aluminum and magnesium hydroxide should be done at least 2 hours after taking rosuvastatin.

Concomitant use with certain medications, such as cyclosporine, gemfibrozil, some antiviral medicines (e.g., those for HIV or hepatitis like lopinavir, ritonavir, atazanavir), and antibiotics like fusidic acid, may require dose adjustments or should be avoided due to an increased risk of side effects like muscle problems. Oral contraceptives and hormone replacement therapy may also have increased side effects when taken with rosuvastatin. Your doctor will assess potential interactions and adjust your treatment plan if necessary.

What precautions should be taken while on ROSUVAS 40 MG TABLET?

Regular monitoring by your doctor is important to check the medicine's effectiveness and to detect any unwanted effects, particularly blood and urine tests to check liver function and muscle health.

Avoid excessive alcohol consumption, as it may increase the risk of liver problems.

Inform your doctor if you have pre-existing conditions such as kidney disease, liver disease (especially active liver disease or elevated liver enzymes, where it should not be used), or diabetes, as these may require careful monitoring or dose adjustments.

Be vigilant for signs of muscle pain, tenderness, or weakness, and report them to your doctor immediately, as these can be serious.

If you need major surgery or develop other serious health problems, your doctor may advise you to temporarily stop taking this medicine.

What happens if a dose is missed?

If you miss a dose of ROSUVAS 40 MG TABLET, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one, as this could increase the risk of side effects.

How should ROSUVAS 40 MG TABLET be stored?

ROSUVAS 40 MG TABLET should be stored in a closed container at room temperature, away from excessive heat, moisture, and direct light. It should be kept from freezing and out of the reach of children and pets. Do not keep outdated medicine or medicine no longer needed, and dispose of it safely as advised by your healthcare professional.