Naprosyn D 500 Mg Tablet (10 Tab)

NAPROSYN D 500 MG TABLET is a medication used to relieve pain, inflammation, and associated symptoms like nausea and vomiting, particularly in conditions such as migraine headaches and various forms of arthritis. It is manufactured by RPG LIFE SCIENCES LIMITED.

Name

• Brand Name: NAPROSYN D 500 MG TABLET
• Common Name: Naproxen with Domperidone

Composition

• Active Ingredients: Each tablet contains Naproxen 500 mg and Domperidone 10 mg.
  • Naproxen is a nonsteroidal anti-inflammatory drug (NSAID) that works by reducing hormones responsible for inflammation and pain in the body.
  • Domperidone is an antiemetic and prokinetic agent that helps control nausea and vomiting by blocking dopamine receptors in the gut and brain, and by enhancing gastric motility.

Uses

NAPROSYN D 500 MG TABLET is prescribed for a range of conditions, including:

• Migraine headaches, including the prevention and treatment of associated nausea and vomiting.
• Pain and inflammation related to various types of arthritis, such as rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, gout, and juvenile idiopathic arthritis.
• Menstrual pain (dysmenorrhea).
• Tendonitis and bursitis.
• General mild to moderate pain, including headaches, dental pain, and post-surgical discomfort.

Dosage and Administration

• The typical dosage is usually once or twice a day, as prescribed by your doctor.
• Swallow the tablet whole with a glass of water; do not crush or chew it.
• It is recommended to take the tablet with food or milk to minimize stomach upset.
• Always adhere to your doctor's prescribed dosage and duration; do not exceed the recommended dose.

Side Effects

• Common Side Effects: Dry mouth, abdominal pain, constipation, drowsiness, dizziness, headache, indigestion, heartburn, nausea, vomiting, visual disturbances, hearing problems, skin rashes, bruising, swelling, and photosensitivity.
• Serious Side Effects: This medicine carries a risk of serious cardiovascular thrombotic events, including heart attack and stroke, which can be fatal. This risk may increase with the duration of use and in individuals with heart disease or risk factors. It can also cause serious gastrointestinal adverse events including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal. Other serious effects include severe allergic reactions, and kidney or liver damage with long-term use.

Precautions

• Important Warnings: NAPROSYN D should not be used for pain immediately before or after coronary artery bypass graft (CABG) surgery due to increased risk of heart attack and stroke.
• Contraindications: Do not use if you are allergic to naproxen, domperidone, aspirin, or other NSAIDs. It is contraindicated in patients with a history of stomach/intestinal ulcers or bleeding, severe heart failure, liver or kidney disease, or a prolactin-releasing pituitary tumor.
• Pregnancy and Breastfeeding: Avoid use in the last trimester of pregnancy as it may cause fetal harm. Use during breastfeeding should only occur if the potential benefits outweigh the risks.
• Interactions: Avoid alcohol, as it increases the risk of stomach bleeding and dizziness. Inform your doctor about all other medications you are taking, especially anticoagulants (e.g., warfarin), other NSAIDs, corticosteroids, antidepressants (SSRIs), blood pressure medications, lithium, and methotrexate, as interactions can occur.
• Special Populations: Use with caution in older adults, and those with a history of heart disease, high blood pressure, high cholesterol, diabetes, or stomach problems.

Storage

• Store in a cool and dry place.
• Protect from heat and direct sunlight.
• Keep out of the reach and sight of children.
• Store below 30ºC.

NAPROSYN D 500 MG TABLET contains Naproxen and Domperidone. Naproxen is a non-steroidal anti-inflammatory drug (NSAID), and Domperidone is an anti-emetic.

What is NAPROSYN D 500 MG TABLET used for?

NAPROSYN D 500 MG TABLET is primarily used to prevent migraines and to relieve pain, swelling, and discomfort associated with various types of arthritis, such as rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, and gout. It can also be used to manage menstrual pain, muscle pain, headaches, dental pain, and post-surgical pain. The domperidone component helps prevent nausea and vomiting that can be associated with migraines or the naproxen itself.

How does NAPROSYN D 500 MG TABLET work?

This medicine works due to its two active ingredients:

• Naproxen: It belongs to a class of medicines called non-steroidal anti-inflammatory drugs (NSAIDs). Naproxen works by inhibiting the production of certain chemical messengers in the body called prostaglandins, which are responsible for causing pain, inflammation, and fever.
• Domperidone: This acts as an anti-emetic (anti-vomiting medicine). It works by blocking dopamine receptors in the brain's chemoreceptor trigger zone and in the gut, thereby preventing nausea and vomiting. It also helps to increase the movement of the stomach and intestines.

What is the usual dosage?

NAPROSYN D 500 MG TABLET should be taken exactly as prescribed by your doctor. It is typically taken once or twice a day with food or milk to help prevent stomach upset. The dose and duration of treatment can vary based on the specific condition and individual response. For adults, a common starting dose of naproxen can be 500 mg, followed by 250 mg every 6 to 8 hours as needed, with a total daily dose not exceeding 1250 mg to 1500 mg.

What are the possible side effects?

Common side effects of NAPROSYN D 500 MG TABLET may include dry mouth, indigestion, abdominal pain, constipation, drowsiness, dizziness, visual disturbances, hearing problems, and headache. More serious, but less common, side effects can include gastrointestinal bleeding or ulcers, cardiovascular events like heart attack or stroke (especially with long-term, high-dose use), and kidney or liver problems. If you experience any severe or persistent side effects, or signs such as chest pain, shortness of breath, black tarry stools, or vomiting blood, seek immediate medical attention.

Is it safe during pregnancy or breastfeeding?

NAPROSYN D 500 MG TABLET is generally not recommended during pregnancy, especially in the third trimester, as it may affect the baby's heart and blood flow and can cause fetal kidney problems leading to low amniotic fluid.

During breastfeeding, naproxen passes into breast milk in small amounts. While adverse effects in breastfed infants are uncommon, there have been rare reports of issues such as prolonged bleeding time, thrombocytopenia, acute anemia, drowsiness, and upset stomach in infants. Due to its long half-life and potential for serious adverse events in newborns, other pain relief options may be preferred, especially for newborn or preterm infants. Consult your doctor to determine the safest approach if you are pregnant or breastfeeding.

Can it be taken with other medications?

NAPROSYN D 500 MG TABLET can interact with various medications, increasing the risk of side effects or reducing the effectiveness of either drug. It's crucial to inform your doctor about all medicines, supplements, or herbal products you are currently taking or plan to take.

Significant interactions can occur with:

• Blood thinners (anticoagulants like warfarin) and antiplatelet agents (like aspirin): Increased risk of bleeding.
• Other NSAIDs (e.g., ibuprofen, ketorolac): Increased risk of stomach problems and other side effects.
• Corticosteroids: Increased risk of gastrointestinal ulcers and bleeding.
• Antihypertensives (medicines for high blood pressure, e.g., ACE inhibitors, ARBs, beta-blockers, diuretics): May reduce their effectiveness or increase the risk of kidney problems.
• Antidepressants (SSRIs, SNRIs): Increased bleeding risk.
• Lithium and methotrexate: Can increase the levels of these drugs in the body, potentially leading to toxicity.
• Antacids (containing aluminum or magnesium) and sucralfate: May affect naproxen absorption.

What precautions should be taken?

Inform your doctor about your complete medical history, especially if you have:

• Heart disease, high blood pressure, high cholesterol, or a history of heart attack or stroke. NSAIDs can increase the risk of cardiovascular events.
• A history of stomach ulcers, gastrointestinal bleeding, or other stomach problems.
• Kidney or liver disease.
• Asthma or allergies to aspirin or other NSAIDs.
• Bleeding disorders.
• Diabetes.
• This medicine should not be used just before or after heart bypass surgery (coronary artery bypass graft, or CABG).
• Avoid alcohol consumption as it may increase the risk of stomach bleeding and dizziness.
• NAPROSYN D 500 MG TABLET may cause dizziness or drowsiness, so avoid driving or operating machinery if you experience these symptoms.
• Do not exceed the recommended dosage.

What happens if a dose is missed?

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a forgotten one.

How should it be stored?

Store NAPROSYN D 500 MG TABLET in a cool and dry place, protected from heat and sunlight. Keep it out of sight and reach of children and pets. Typically, it should be stored at temperatures between 10ºC to 25ºC or below 30ºC.