Repace Af Tablet (10 Tab)

REPACE AF TABLET (10 TAB) by SUN PHARMA LABORATORIES LTD.

Name: Repace AF Tablet

Composition: Repace AF Tablet is a combination medication containing two active ingredients:

• Amlodipine (5 mg)
• Losartan (50 mg)

Uses: This medicine is primarily prescribed for the treatment of high blood pressure (hypertension). It works by relaxing blood vessels and making it easier for the heart to pump blood throughout the body, thereby reducing blood pressure. This action helps in lowering the risk of serious cardiovascular events such as heart attacks and strokes. Repace AF Tablet may also be beneficial for patients with coexisting conditions like left ventricular hypertrophy or type 2 diabetes with nephropathy.

Dosage and Administration: Repace AF Tablet should be taken orally as directed by a doctor. It is typically administered once daily, either with or without food, but it is recommended to take it at a fixed time each day to maintain consistent levels in the body. The tablet should be swallowed whole and not chewed, crushed, or broken. Do not stop taking this medicine without consulting your doctor, even if you feel well, as it can lead to complications.

Side Effects: Common side effects may include:

• Dizziness, headache, fatigue, and sleepiness
• Swelling in hands, feet, or ankles
• Nausea, stomach upset, or abdominal pain
• Low blood pressure (hypotension)
• Palpitations (irregular heartbeats)
• Cough, taste alterations, back pain, or chest tightness
• Flushing (feeling of warmth in the face, ears, neck, and trunk)

Serious, though less common, side effects can include liver dysfunction, severe allergic reactions, heart failure, elevated potassium levels (hyperkalaemia), kidney problems, and angioedema (swelling of deeper layers of skin). If any side effects persist or worsen, immediate medical attention is advised.

Precautions:

• Pregnancy and Breastfeeding: Repace AF Tablet is considered highly unsafe and should be avoided during pregnancy, especially in the second and third trimesters, due to potential harm to the fetus. While it may be safe during breastfeeding if prescribed, it is generally not recommended.
• Liver and Kidney Conditions: Use with caution in patients with liver disease; dosage adjustments and monitoring may be necessary. Patients with kidney problems or severe dehydration should also inform their doctor. Regular monitoring of kidney function is crucial.
• Alcohol and Grapefruit Juice: Alcohol consumption is unsafe as it may enhance the blood pressure-lowering effect and increase the risk of dizziness. Avoid consuming grapefruit juice as it may interact with the medicine.
• Potassium Levels: The medication may increase potassium levels in the blood. Avoid potassium-rich foods or supplements unless advised by your doctor.
• Driving: This medicine may cause dizziness or sleepiness, which could affect the ability to drive or operate machinery.
• Children: Not recommended for use in children below 18 years of age.
• Other Conditions: Caution is advised for patients with low blood pressure, congestive heart failure, or aortic stenosis.

Storage: Store Repace AF Tablet in a cool and dry place, away from direct sunlight and out of reach of children. It should be stored at room temperature, typically between 10ºC to 25ºC or below 30ºC.

What is REPACE AF TABLET used for?

REPACE AF TABLET is primarily used to manage high blood pressure, also known as hypertension. It helps prevent serious complications associated with high blood pressure, such as heart attacks, strokes, and kidney problems. This medication may also be beneficial for individuals with coexisting conditions like left ventricular hypertrophy or type 2 diabetes with kidney complications.

How does REPACE AF TABLET work?

REPACE AF TABLET is a combination medication containing Losartan and Amlodipine. Losartan, an angiotensin II receptor blocker (ARB), works by blocking a hormone that tightens blood vessels and causes the body to retain salt and water, thereby helping blood vessels relax and reducing fluid. Amlodipine, a calcium channel blocker (CCB), relaxes and widens blood vessels by blocking calcium entry into their muscle walls. Together, these two ingredients relax the blood vessels, make it easier for the heart to pump blood throughout the body, and effectively lower blood pressure.

What is the usual dosage for REPACE AF TABLET?

The dosage of REPACE AF TABLET is determined by your doctor based on your specific medical condition and how you respond to the medication. It is typically taken orally with a full glass of water, with or without food. To ensure consistent levels of the medication in your body, it is advisable to take it at the same time each day. Do not crush, chew, or break the tablet; swallow it whole. The common dosage strength often involves Losartan (50mg) and Amlodipine (5mg).

What are the possible side effects of REPACE AF TABLET?

Common side effects may include headache, dizziness, fatigue, nausea, abdominal pain, ankle swelling (edema), upset stomach, sleepiness, flushing (a sense of warmth in the face), palpitations, and taste changes. Most of these side effects are usually mild and tend to disappear over time. However, if any side effects persist, worsen, or cause concern, you should consult your doctor immediately.

Is REPACE AF TABLET safe during pregnancy or breastfeeding?

REPACE AF TABLET is generally not recommended and is considered highly unsafe during pregnancy, particularly in the second and third trimesters, due to potential risks to the unborn child. For breastfeeding mothers, caution is advised as the medication may pass into breast milk and potentially harm the nursing infant. It is crucial to consult your doctor for alternative treatment options if you are pregnant, planning to conceive, or breastfeeding.

Can REPACE AF TABLET be taken with other medications?

It is important to inform your doctor about all other medications you are currently taking, including over-the-counter drugs, herbal supplements, and vitamins, to avoid potential drug interactions.

• Avoid with: Potassium supplements and potassium-sparing diuretics (e.g., spironolactone) as they can significantly increase blood potassium levels.
• Use with caution with: Other blood pressure-lowering medicines, NSAIDs (e.g., ibuprofen), lithium, and some antifungal medications.
• Avoid grapefruit and grapefruit juice: These can increase the levels of Amlodipine in the body, leading to increased side effects.
• Avoid potassium-rich foods: Foods high in potassium, like bananas and spinach, can increase blood potassium levels when taken with this medication.
• Limit high-sodium foods: High-sodium foods can reduce the effectiveness of REPACE AF TABLET in lowering blood pressure.

What precautions should be taken while taking REPACE AF TABLET?

Before taking REPACE AF TABLET, inform your doctor if you have any pre-existing medical conditions, especially kidney or liver problems, severe dehydration, or a history of angioedema. It is advisable to avoid alcohol consumption, as it can enhance side effects such as dizziness and low blood pressure. Since this medication may cause dizziness or sleepiness, exercise caution when driving or operating machinery until you understand how it affects you. You should also rise slowly from a sitting or lying position to prevent lightheadedness. Continue taking the medication for the entire duration prescribed by your doctor, even if you start to feel better, to ensure optimal results and prevent a relapse of your condition.

What happens if a dose of REPACE AF TABLET is missed?

If you miss a dose of REPACE AF TABLET, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one, as this can lead to an overdose and increased side effects.

How should REPACE AF TABLET be stored?

REPACE AF TABLET should be stored in a cool, dry place at room temperature, away from direct sunlight, moisture, and excessive heat. Always keep the medication out of the reach of children and pets. It is also good practice to check the expiry date before using the medicine.