Diof Suspension

DIOF SUSPENSION by ZUVENTUS HEALTHCARE LTD.

DIOF SUSPENSION is an antibiotic medication manufactured by Zuventus Healthcare Ltd., primarily used to treat a wide range of bacterial and parasitic infections.

• Composition DIOF SUSPENSION contains Ofloxacin (50 mg/5 ml) and Metronidazole (100 mg/5 ml) as its active ingredients. Ofloxacin is a fluoroquinolone antibiotic that inhibits bacterial DNA replication, while Metronidazole is a nitroimidazole antibiotic that damages the DNA of bacteria and parasites, thereby killing them.

• Uses This suspension is prescribed for various bacterial and protozoal infections, including diarrhea and dysentery caused by mixed infections. It is also effective in treating infections of the teeth, gums, lungs (pneumonia), gastrointestinal tract, urinary tract, genital tract, and skin and soft tissues.

• Dosage and Administration DIOF SUSPENSION should be taken orally, preferably at a fixed time, with or without food, as directed by a healthcare professional. Shake the bottle well before each use and measure the exact quantity with a provided measuring device. It is crucial to complete the full prescribed course of treatment, even if symptoms improve, to prevent infection recurrence and antibiotic resistance.

• Side Effects Common side effects may include nausea, vomiting, diarrhea, loss of appetite, headache, metallic taste, dizziness, insomnia, and urine discoloration (red-brown, due to metronidazole). More serious, though less common, side effects can include tendinitis, tendon rupture, peripheral neuropathy (tingling/burning sensation), and central nervous system effects such as confusion, anxiety, hallucinations, or seizures.

• Precautions Do not administer calcium, magnesium, iron supplements, vitamins, or antacids within two hours of taking DIOF SUSPENSION, as they can interfere with its absorption. Alcohol consumption should be avoided during treatment and for at least three days after completing the course due to the risk of a disulfiram-like reaction. Caution is advised in patients with a history of liver or kidney disease, central nervous system disorders (e.g., epilepsy), or heart conditions. Patients should be monitored for signs of tendon inflammation or rupture. Discontinue use and seek medical attention if severe allergic reactions, skin rash, swelling, or difficulty breathing occur.

• Storage Store DIOF SUSPENSION below 25°C in a cool, dry place, protected from direct light. Do not freeze, and keep it out of reach of children.

DIOF SUSPENSION by Zuventus Healthcare Ltd. is an antibiotic medication that combines Ofloxacin and Metronidazole, used to treat a variety of bacterial and parasitic infections.

Here are some frequently asked questions about DIOF SUSPENSION:

What is DIOF SUSPENSION used for?

DIOF SUSPENSION is primarily used to treat bacterial and parasitic infections. This includes various conditions such as infectious diarrhea, dysentery, and infections affecting the skin, throat, ear, lungs, gastrointestinal tract, urinary tract, and genital tract. It is also prescribed for conditions like pneumonia, bronchitis, pyelonephritis, cystitis, prostatitis, and joint infections.

How does DIOF SUSPENSION work?

DIOF SUSPENSION contains two active ingredients: Ofloxacin and Metronidazole. Ofloxacin is a fluoroquinolone antibiotic that works by inhibiting bacterial DNA gyrase and topoisomerase IV enzymes, which are crucial for bacterial DNA replication and repair, leading to the death of bacterial cells. Metronidazole is a nitroimidazole antibiotic that kills parasites and anaerobic bacteria by damaging their DNA. Together, they effectively eliminate the infection-causing organisms.

What is the usual dosage of DIOF SUSPENSION?

The dosage of DIOF SUSPENSION is determined by your doctor based on the type and severity of the infection, as well as your age and body weight. It is typically given in two divided doses per day. Always follow your doctor's instructions precisely regarding the dose and duration of treatment. The suspension should be shaken well before use and can be taken with or without food, preferably at a fixed time each day.

What are the possible side effects of DIOF SUSPENSION?

Common side effects may include nausea, vomiting, diarrhea, stomach pain or cramps, indigestion, loss of appetite, headache, dizziness, a metallic taste in the mouth, dry mouth, and urine discoloration (which can appear red-brown due to Metronidazole and is usually harmless). More serious but less common side effects can include tendinitis or tendon rupture, central nervous system effects such as seizures or hallucinations, and allergic reactions (e.g., swelling of the face, lips, throat, or tongue, difficulty breathing). If you experience severe or persistent side effects, contact your doctor immediately.

Is DIOF SUSPENSION safe during pregnancy or breastfeeding?

DIOF SUSPENSION is generally not recommended during pregnancy, particularly in the first trimester, due to potential risks to the fetus. It is also not advised for breastfeeding mothers as its components can pass into breast milk and may affect the infant, with potential adverse effects on joint development. Always consult your doctor if you are pregnant, planning to become pregnant, or breastfeeding.

Can DIOF SUSPENSION be taken with other medications?

DIOF SUSPENSION can interact with several medications. For example, antacids containing aluminum, magnesium, or calcium, as well as iron or zinc supplements, can reduce the absorption of Ofloxacin; these should be taken at least two hours before or after DIOF SUSPENSION. It can also enhance the effects of blood thinners like warfarin, increasing the risk of bleeding. Taking it with theophylline may increase theophylline levels, and with NSAIDs, it may increase the risk of CNS stimulation. It should not be taken with disulfiram within two weeks, and alcohol consumption must be avoided during treatment and for at least three days afterward due to potential severe reactions. Always inform your doctor about all other medications, supplements, or herbal products you are taking.

What precautions should be taken while using DIOF SUSPENSION?

You should inform your doctor if you have any known allergies to Ofloxacin, Metronidazole, or similar antibiotics (fluoroquinolones, nitroimidazoles). Caution is advised if you have a history of tendon problems, central nervous system disorders (like epilepsy or seizures), myasthenia gravis, liver or kidney disease, or certain heart conditions (e.g., irregular heartbeat, QT prolongation). This medication may cause dizziness, confusion, or blurred vision, so avoid driving or operating machinery until you know how it affects you. Also, be aware that it can increase sensitivity to sunlight. It is crucial to complete the entire course of treatment, even if symptoms improve, to prevent the infection from returning or becoming resistant.

What happens if a dose of DIOF SUSPENSION is missed?

If you miss a dose of DIOF SUSPENSION, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one.

How should DIOF SUSPENSION be stored?

DIOF SUSPENSION should be stored in a cool, dry place, typically below 25°C or 30°C, and protected from light. It should not be frozen. Always keep the medicine out of the sight and reach of children and pets.