Lasmiray 100 Tab

LASMIRAY 100 TAB is a medication manufactured by Torrent Pharma (Neuron) designed for the acute treatment of migraine attacks.

Name

• Brand Name: LASMIRAY 100 TAB
• Generic Name: Lasmiditan Tablets (100 mg)

Composition

Each film-coated tablet contains:

• Lasmiditan Hemisuccinate equivalent to Lasmiditan 100 mg
• Excipients include Microcrystalline cellulose, Sodium lauryl sulphate, Pregelatinized starch, Croscarmellose Sodium, Colloidal silicon dioxide, Magnesium Stearate, and Opadry II White.

Uses

LASMIRAY 100 TAB is indicated for the acute treatment of migraine attacks, with or without aura, in adults. It helps to relieve migraine symptoms once they begin and prevents the attack from worsening. It is not intended for the preventive treatment of migraines.

Dosage and Administration

The recommended initial dose in adults for acute treatment of migraine attacks is 100 mg lasmiditan. It is typically administered as one tablet once daily, as advised by a physician. The dose can be adjusted (increased to 200 mg for greater efficacy or decreased to 50 mg for greater tolerability) if necessary. If a migraine recurs within 24 hours of an initial response, a second dose of the same strength may be taken, but not within 2 hours of the initial dose. A total of no more than 200 mg should be taken within 24 hours. The tablet should be swallowed whole and can be taken with or without food. Do not chew, crush, or break the tablet. It should not be used for headaches that are not migraines.

Side Effects

Common side effects may include:

• Dizziness
• Fatigue
• Paresthesia (tingling or pricking sensation)
• Sedation/Sleepiness

Serious side effects, though rare, can include:

• Serotonin syndrome (symptoms may include agitation, fever, confusion, or muscle stiffness).
• Severe allergic reactions (e.g., swelling, rash).
• Hypersensitivity reactions, including angioedema.
• Decreases in heart rate and transient increases in blood pressure.

Precautions

• Inform your doctor about any allergies to Lasmiray 100 Tablet, other medications, or its ingredients.
• Caution is advised for patients with heart problems, high blood pressure, or a slow/irregular heartbeat, as the use of Lasmiray 100 Tablet is contraindicated in some heart diseases and may worsen these conditions. Regular monitoring of blood pressure is required.
• Due to potential sleepiness and other cognitive effects, do not drive or operate machinery until you know how this medicine affects you.
• Use with caution in combination with alcohol or other CNS depressants due to increased potential for sedation and other adverse reactions.
• Not recommended for patients with severe liver disease.
• Consult a doctor if pregnant or breastfeeding, as animal studies have shown harmful effects on the developing baby.
• Inform your doctor about all other prescription, non-prescription medications, vitamins, nutritional supplements, and herbal products being taken.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Store below 25°C or 30°C.

Here are the most frequently asked questions about LASMIRAY 100 TAB:

1. What is Lasmiray 100 Tablet used for?

Lasmiray 100 Tablet is used for the acute treatment of migraine attacks, with or without aura, in adults. It helps alleviate migraine symptoms once they begin but is not intended to prevent future migraines.

2. How does Lasmiray 100 Tablet work?

Lasmiray 100 Tablet (Lasmiditan) is a high-affinity, centrally-penetrant 5-hydroxytryptamine 1F (5-HT1F) receptor agonist. Its therapeutic effects are believed to involve decreasing neuropeptide release and inhibiting pain pathways, including the trigeminal nerve, thereby helping to improve blood flow in the brain and prevent abnormal activity that triggers migraines.

3. What is the usual dosage for Lasmiray 100 Tablet?

The recommended initial dose for adults is 100 mg for an acute migraine attack. Depending on efficacy and tolerability, the dose can be adjusted to 200 mg or decreased to 50 mg. If the migraine recurs within 24 hours of the initial dose (50 mg or 100 mg), a second dose of the same strength may be taken, but not within 2 hours of the first dose. Do not take more than 200 mg within a 24-hour period. It should not be taken daily for migraine prevention. The tablet can be taken with or without food, and should be swallowed whole without chewing, crushing, or breaking.

4. What are the possible side effects of Lasmiray 100 Tablet?

Common side effects include dizziness, fatigue, paresthesia (tingling or pricking sensation), and sedation (sleepiness). These are usually temporary and often resolve on their own. In rare cases, more serious side effects like serotonin syndrome (symptoms include agitation, fever, confusion, or muscle stiffness) or severe allergic reactions (like swelling or rash) may occur.

5. Is Lasmiray 100 Tablet safe during pregnancy or breastfeeding?

Lasmiray 100 Tablet may be unsafe to use during pregnancy as animal studies have shown harmful effects on the developing baby, and human data is limited. It is generally not recommended during pregnancy, and your doctor will assess the benefits and potential risks before prescribing it. Regarding breastfeeding, information on its presence in human milk is not available, though it has been found in rat milk. It's advisable to consult your doctor, and if used, exposure to the infant can be minimized by avoiding breastfeeding for 24 hours after treatment.

6. Can Lasmiray 100 Tablet be taken with other medications?

Caution is advised when taking Lasmiray 100 Tablet with other medications. Concomitant use with serotonergic medicinal products (such as SSRIs, SNRIs, TCAs, and MAO inhibitors) may increase the risk of serotonin syndrome. Additionally, Lasmiditan can lower heart rate, and combining it with other heart rate-lowering medications (e.g., Propranolol) might cause an additional decrease. Use with alcohol or other central nervous system (CNS) depressants should also be approached with caution due to the potential for increased sedation and other CNS adverse reactions.

7. What precautions should be taken while using Lasmiray 100 Tablet?

Due to potential side effects like sleepiness and dizziness, you should not drive or operate machinery for at least 8 hours after taking each dose of Lasmiray 100 Tablet. Inform your doctor if you have any heart problems, as the medicine is contraindicated in some heart conditions, and regular blood pressure monitoring may be required. It should also be used with caution in patients with severe liver disease. Do not exceed the prescribed dose or duration, and remember it is not for daily preventive use. Taking migraine medications for 10 or more days per month can sometimes worsen headaches (medication overuse headache).

8. What happens if a dose of Lasmiray 100 Tablet is missed?

Lasmiray 100 Tablet is taken for acute migraine attacks as needed, not on a regular schedule. Therefore, the concept of a "missed dose" for a daily medication does not directly apply. If you have an acute migraine, take it as directed. If your migraine returns after an initial response, a second dose may be taken after at least 2 hours, but do not take more than 200 mg in 24 hours.

9. How should Lasmiray 100 Tablet be stored?

Store Lasmiray 100 Tablet in a closed container at room temperature, away from heat, moisture, and direct light. Keep all medications out of reach of children and pets.