Pregabid D 50/20

PREGABID D 50/20 by INTAS PHARMACEUTICALS LTD

PREGABID D 50/20 is a combination medication manufactured by Intas Pharmaceuticals Ltd..

• Name:

  • Brand Name: PREGABID D 50/20, Pregabid-D 50/20 Capsule DR
  • Common Name: Pregabalin and Duloxetine combination.

• Composition:

  • Each capsule contains Pregabalin 50 mg and Duloxetine 20 mg. Pregabalin is an anticonvulsant, and Duloxetine is a selective serotonin and norepinephrine reuptake inhibitor (SNRI).

• Uses: PREGABID D 50/20 is primarily used for the management of chronic pain conditions. It is prescribed for:

  • Diabetic neuropathic pain.
  • Fibromyalgia.
  • Neuropathic pain (nerve pain).
  • Post-herpetic neuralgia (nerve pain after shingles).
  • Chronic musculoskeletal pain.
  • May also be used for anxiety disorders and as an adjunctive treatment for partial seizures.

• Dosage and Administration: This medicine should be taken orally as prescribed by a doctor. It can be taken with or without food, preferably at the same time each day to maintain consistent levels. Swallow the capsule whole; do not chew, crush, or break it. Do not stop taking it suddenly, as it may cause withdrawal symptoms; the dosage should be gradually decreased under medical supervision. Not recommended for use in children below 18 years of age.

• Side Effects: Common side effects may include:

  • Nausea, constipation, dry mouth.
  • Headache, dizziness, drowsiness, fatigue.
  • Increased sweating, loss of appetite, weight gain.
  • Blurred vision, difficulty concentrating.
  • Tingling or numbness, burning sensation.
  • Peripheral edema (swelling in the limbs).
  • Insomnia (difficulty in sleeping).
  • Ejaculation disorder, erectile dysfunction, decreased sexual drive.

  Serious side effects, though rare, can include suicidal thoughts or behavior, severe allergic reactions, abnormal bleeding, and low sodium levels. Seek immediate medical attention if any severe symptoms occur.

• Precautions:

  • Inform your doctor if you have allergies to Pregabalin or Duloxetine, or any other components of the medicine.
  • Use with caution in patients with liver or kidney disease, seizures, mania, bipolar disorder, glaucoma, or bleeding disorders.
  • Avoid alcohol consumption as it may increase drowsiness and the risk of liver damage.
  • This medicine may cause dizziness and drowsiness, so avoid driving or operating heavy machinery until you know how it affects you.
  • Inform your doctor if you are pregnant or breastfeeding, as it may be unsafe during these periods.
  • Interactions can occur with blood thinners (e.g., aspirin, warfarin), certain antibiotics (e.g., ciprofloxacin), SSRIs (e.g., sertraline), lithium, and dextromethorphan.
  • Caution is advised in elderly patients due to an increased risk of falls and dizziness.

• Storage: Store PREGABID D 50/20 in a cool and dry place, away from direct sunlight and moisture. Keep it out of the sight and reach of children and pets. Store below 30°C or at room temperature (20-25°C).

PREGABID D 50/20, manufactured by INTAS PHARMACEUTICALS LTD, is a combination medication containing Pregabalin (50 mg) and Duloxetine (20 mg). It is primarily prescribed for chronic pain conditions, particularly those involving nerve damage.

What is PREGABID D 50/20 used for?

PREGABID D 50/20 is used for the management of neuropathic pain, which is nerve pain caused by conditions like diabetes (diabetic neuropathy), shingles (post-herpetic neuralgia), and spinal cord injuries. It is also prescribed for widespread musculoskeletal pain associated with fibromyalgia.

How does PREGABID D 50/20 work?

This medicine works through its two active ingredients. Pregabalin helps reduce nerve pain by controlling the activity of calcium channels in overactive nerve cells, thereby blocking pain signals. Duloxetine, an antidepressant, increases the levels of certain chemical messengers (serotonin and norepinephrine) in the brain and spinal cord, which helps regulate mood and inhibit the movement of pain signals.

What is the usual dosage for PREGABID D 50/20?

The dosage of PREGABID D 50/20 is determined by your doctor based on your condition and response to treatment. It is typically taken once or twice a day, with or without food. It's important to take it at the same time daily to maintain consistent levels in the body and follow your doctor's instructions for dosage and duration.

What are the possible side effects of PREGABID D 50/20?

Common side effects can include dizziness, drowsiness, headache, nausea, dry mouth, blurred vision, increased appetite, weight gain, constipation, fatigue, peripheral edema (swelling in the limbs), and difficulty concentrating. More serious, but less common, side effects may include changes in mood or behavior, including suicidal thoughts, and a reduced sex drive. If side effects are persistent or severe, consult your doctor.

Is PREGABID D 50/20 safe during pregnancy or breastfeeding?

PREGABID D 50/20 should generally be avoided during pregnancy and breastfeeding. It may be unsafe during pregnancy, especially in the last trimester, and both Pregabalin and Duloxetine can pass into breast milk, potentially causing adverse effects in a nursing infant. Always inform your doctor if you are pregnant, planning a pregnancy, or breastfeeding.

Can PREGABID D 50/20 be taken with other medications?

It's crucial to inform your doctor about all medicines, supplements, or herbal products you are currently taking to avoid possible interactions. PREGABID D 50/20 can interact with medicines for brain-related disorders, blood thinners (e.g., aspirin, warfarin), and other serotonergic drugs (e.g., MAOIs, triptans, some antidepressants like SSRIs, and certain antibiotics like ciprofloxacin).

What precautions should be taken while on PREGABID D 50/20?

You should avoid consuming alcohol as it can increase side effects like dizziness, drowsiness, and blurred vision. Do not drive or operate heavy machinery until you understand how the medication affects you, as it can cause dizziness and sleepiness. Inform your doctor if you have kidney or liver disease, heart conditions, diabetes, glaucoma, a history of seizures, mood disorders (depression, bipolar disorder), or suicidal thoughts. This medicine is generally not recommended for patients under 18 years of age.

What happens if a dose of PREGABID D 50/20 is missed?

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one.

How should PREGABID D 50/20 be stored?

Store PREGABID D 50/20 in dry conditions at room temperature (below 30°C), away from moisture and direct sunlight. Keep it out of the sight and reach of children.

Is PREGABID D 50/20 habit-forming?

Yes, PREGABID D 50/20 has the potential to be habit-forming, particularly due to the Pregabalin component. It's important to take it exactly as prescribed by your doctor and not to stop the medication suddenly, as abrupt discontinuation can lead to withdrawal symptoms. Your doctor will provide guidance on gradually reducing the dose if discontinuation is necessary.