Zoryl Mp 1 Mg Tablet (15 Tab)

ZORYL MP 1 MG TABLET

ZORYL MP 1 MG TABLET, manufactured by Intas Pharmaceuticals Ltd., is a combination medication used for the comprehensive management of type 2 diabetes mellitus.

• Name: ZORYL MP 1 MG TABLET (Brand Name)

• Composition: Each tablet contains Glimepiride (1 mg), Metformin (500 mg), and Pioglitazone (15 mg).

  • Glimepiride: A sulfonylurea that stimulates the pancreas to produce more insulin.
  • Metformin: A biguanide that reduces glucose production in the liver and improves the body's sensitivity to insulin.
  • Pioglitazone: A thiazolidinedione that increases insulin sensitivity in muscle, fat, and liver cells.

• Uses: This medicine is prescribed for adults with type 2 diabetes mellitus to control blood sugar levels when diet and exercise alone, or treatment with single or dual antidiabetic agents, are insufficient. It helps improve glycemic control and reduces the risk of diabetes-related complications.

• Dosage and Administration: ZORYL MP 1 MG TABLET should be taken once daily with food, or as directed by a physician, to minimize gastrointestinal side effects. The tablet should be swallowed whole and not crushed or chewed. Regular blood sugar monitoring is crucial during treatment.

• Side Effects:

  • Common: Hypoglycemia (low blood sugar), nausea, diarrhea, stomach pain, headache, edema (swelling), weight gain, blurred vision, and upper respiratory tract infection.
  • Serious (rare): Lactic acidosis (symptoms include cold hands/feet, dizziness, unusual muscle pain, trouble breathing), and symptoms of heart failure.

• Precautions: This medicine is contraindicated in patients with severe kidney or liver disease, type 1 diabetes mellitus, bladder cancer, severe heart failure, or a history of lactic acidosis. Caution is advised for pregnant or breastfeeding women, and alcohol consumption should be avoided as it may increase the risk of lactic acidosis. Inform your doctor about any pre-existing medical conditions, especially heart, kidney, or liver problems.

• Storage: Store ZORYL MP 1 MG TABLET at room temperature, below 25°C or 30°C, in a cool and dry place. Keep the container tightly closed to protect from light and moisture, and out of reach of children.

What is ZORYL MP 1 MG TABLET used for?

ZORYL MP 1 MG TABLET is primarily used to manage type 2 diabetes mellitus in adults. It is prescribed when diet, exercise, and other single medications are not sufficient to control blood sugar levels effectively. This medicine helps improve blood sugar control and reduces the risk of long-term diabetes-related complications such as neuropathy and retinopathy.

How does ZORYL MP 1 MG TABLET work?

ZORYL MP 1 MG TABLET is a combination medication containing three active ingredients: Glimepiride (1mg), Metformin (500mg), and Pioglitazone (15mg).

• Glimepiride is a sulfonylurea that stimulates the pancreas to release more insulin.
• Metformin is a biguanide that works by reducing the production of glucose in the liver, decreasing the absorption of glucose from the intestines, and improving the body's sensitivity to insulin.
• Pioglitazone is a thiazolidinedione that increases insulin sensitivity in the body's cells, particularly in liver and muscle tissues, allowing them to utilize insulin more effectively. Together, these components work through different mechanisms to lower blood sugar levels and maintain glycemic control.

What is the usual dosage for ZORYL MP 1 MG TABLET?

ZORYL MP 1 MG TABLET is typically taken once a day, as directed by your doctor. It should be taken with food to minimize potential gastrointestinal side effects. The tablet should be swallowed whole with a glass of water and not crushed or chewed. Your doctor will determine the precise dose and duration of treatment based on your individual condition and response to the medication.

What are the possible side effects of ZORYL MP 1 MG TABLET?

Common side effects may include low blood sugar levels (hypoglycemia), nausea, diarrhea, headache, dizziness, stomach pain, loss of appetite, a metallic taste in the mouth, weight gain, upper respiratory tract infection, muscle pain, and swelling (oedema). Serious but rare side effects can include lactic acidosis, severe hypoglycemia, liver issues, or allergic reactions. If any side effects persist or worsen, it is important to consult your doctor.

Is ZORYL MP 1 MG TABLET safe during pregnancy or breastfeeding?

Pregnancy: ZORYL MP 1 MG TABLET is generally not recommended for use during pregnancy as it may harm the unborn baby. If you are pregnant or planning to conceive, your doctor may suggest alternative treatment options. Breastfeeding: This medicine is not recommended for use during breastfeeding because it may pass into human milk and potentially cause adverse effects in the nursing infant. You should consult your doctor for safe alternatives if you are a breastfeeding mother.

Can ZORYL MP 1 MG TABLET be taken with other medications?

Yes, ZORYL MP 1 MG TABLET can be taken with other medications, but it's crucial to inform your doctor about all prescription and non-prescription medicines, supplements, or herbal products you are currently taking to avoid potential drug interactions. Some medicines that may interact include:

• Other antidiabetic medications, which can increase the risk of hypoglycemia.
• Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) like ibuprofen and aspirin, which might enhance the blood sugar-lowering effect of glimepiride.
• Certain cationic medications (e.g., amiloride, digoxin, ranitidine) may increase the accumulation of metformin, raising the risk of lactic acidosis.
• Strong inhibitors of the CYP2C8 enzyme (e.g., gemfibrozil) can significantly increase pioglitazone levels in the body.
• Alcohol consumption should be avoided as it can increase the risk of lactic acidosis and hypoglycemia.

What precautions should be taken while using ZORYL MP 1 MG TABLET?

It is important to monitor your blood sugar levels regularly while taking ZORYL MP 1 MG TABLET. You should avoid alcohol consumption, as it can increase the risk of serious side effects like lactic acidosis and hypoglycemia. Inform your doctor if you have any pre-existing kidney, liver, or heart conditions, as this medication may not be suitable or may require dose adjustment. ZORYL MP 1 MG TABLET is not recommended for individuals with type 1 diabetes, diabetic ketoacidosis, severe kidney or liver failure, or class III/IV heart failure. Additionally, caution is advised if you have a history of bladder cancer due to the pioglitazone component. Maintaining a balanced diet and regular exercise regimen is also crucial for effective diabetes management. Always carry a source of sugar (like candy or fruit juice) to quickly manage symptoms of low blood sugar.

What happens if a dose of ZORYL MP 1 MG TABLET is missed?

If you miss a dose of ZORYL MP 1 MG TABLET, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to compensate for a missed one. Missing a dose can lead to elevated blood sugar levels.

How should ZORYL MP 1 MG TABLET be stored?

ZORYL MP 1 MG TABLET should be stored at room temperature, generally below 25°C or 30°C, in a cool and dry place. Ensure the container is tightly closed to protect the tablets from light and moisture. Keep the medicine out of the reach and sight of children and pets.