Empagreat S 25mg Tab

EMPAGREAT S 25MG TABLET

EMPAGREAT S 25MG Tablet, manufactured by Mankind Pharma Ltd., is a combination medication primarily used for the management of type 2 diabetes mellitus. It works by utilizing two distinct active ingredients to effectively control blood sugar levels.

Composition Each EMPAGREAT S 25MG Tablet contains:

• Empagliflozin (25 mg): A sodium-glucose co-transporter 2 (SGLT2) inhibitor. It works by blocking SGLT2 in the kidneys, which leads to the removal of excess glucose from the body through urine, thereby lowering blood sugar.
• Sitagliptin (100 mg): A dipeptidyl peptidase-4 (DPP-4) inhibitor. Sitagliptin increases incretin hormone levels, which enhances insulin release after meals and reduces glucose production by the liver.

Uses EMPAGREAT S 25MG Tablet is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus. This combination therapy provides comprehensive glucose control by targeting both renal and pancreatic pathways. It may also offer benefits in reducing cardiovascular risks and kidney complications associated with type 2 diabetes.

Dosage and Administration The typical dosage of Empagliflozin and Sitagliptin combinations is usually once daily. Dosage should be individualized based on the patient's current regimen and medical condition. It is generally recommended to take the tablet with food.

Side Effects Common side effects can include:

• Urinary tract infections (UTIs) and genital fungal infections (e.g., vaginal yeast infections in women, penile yeast infections in men).
• Increased urination.
• Headache, nasopharyngitis, and mild gastrointestinal upset (such as nausea, constipation).
• Dehydration.

Serious side effects, though rare, may include:

• Diabetic ketoacidosis (DKA), which can occur even with blood sugar levels below 250 mg/dL.
• Hypoglycemia (low blood sugar), especially when taken with other diabetes medications like insulin or sulfonylureas.

Precautions

• EMPAGREAT S 25MG Tablet is not recommended for patients with type 1 diabetes or diabetic ketoacidosis.
• It should be used with caution in elderly patients and those with kidney impairment. Renal function should be assessed before starting treatment and monitored periodically.
• Patients should maintain adequate hydration to prevent dehydration, especially if taking diuretics.
• Inform your doctor if you have a history of kidney or liver problems, urinary tract infections, or heart conditions.
• Temporary discontinuation may be advised before surgery or major medical procedures.
• Pregnant and breastfeeding women should consult their doctor before use.

Storage Store EMPAGREAT S 25MG Tablet below 30°C. Keep all medicines out of the reach of children and pets.

EMPAGREAT S 25MG Tablet is a combination medication containing Empagliflozin (25 mg) and Sitagliptin (100 mg). It is prescribed for adults with type 2 diabetes mellitus to help control blood sugar levels.

Here are some frequently asked questions about EMPAGREAT S 25MG Tablet:

What is EMPAGREAT S 25MG Tablet used for?

EMPAGREAT S 25MG Tablet is primarily used as an adjunct to diet and exercise to improve blood sugar control in adults with type 2 diabetes mellitus. It also helps reduce the risk of serious complications associated with diabetes, such as cardiovascular disease, kidney damage, nerve issues, and vision loss. The empagliflozin component also has benefits in reducing the risk of cardiovascular death, hospitalization for heart failure, and slowing the progression of chronic kidney disease.

How does EMPAGREAT S 25MG Tablet work?

EMPAGREAT S 25MG Tablet contains two active ingredients:

• Empagliflozin (25 mg): This is a sodium-glucose co-transporter 2 (SGLT2) inhibitor. It works by blocking SGLT2 proteins in the kidneys, which are responsible for reabsorbing most of the glucose back into the bloodstream. By inhibiting SGLT2, empagliflozin increases the amount of glucose excreted in the urine, thereby lowering blood sugar levels. Its action is independent of insulin.
• Sitagliptin (100 mg): This is a dipeptidyl peptidase-4 (DPP-4) inhibitor. It works by increasing the levels of natural substances called incretins in the body. Incretins help improve insulin release after meals and reduce the amount of glucose produced by the liver, contributing to better blood sugar control.

What is the usual dosage for EMPAGREAT S 25MG Tablet?

The usual dosage for EMPAGREAT S 25MG Tablet is typically once daily, as prescribed by your doctor. The doctor will determine the appropriate dose based on your condition and response to treatment. It can be taken with or without food, but it is recommended to take it at the same time each day.

What are the possible side effects of EMPAGREAT S 25MG Tablet?

Common side effects may include vaginal yeast infections or other genital infections, urinary tract infections, increased urination, constipation, rash, itching, upper respiratory tract infections, and headache. Some individuals, especially when taking it with other antidiabetic medicines like insulin or sulfonylureas, may experience low blood sugar (hypoglycemia). If you experience any serious or persistent side effects, consult your doctor.

Is EMPAGREAT S 25MG Tablet safe during pregnancy or breastfeeding?

EMPAGREAT S 25MG Tablet is generally not recommended during pregnancy. Its safety has not been established, and animal studies suggest possible risks to the developing baby. Similarly, it is probably unsafe during breastfeeding, as it is not known whether the components pass into human breast milk, and animal studies suggest they may. Always consult your doctor for safer alternatives if you are pregnant or breastfeeding.

Can EMPAGREAT S 25MG Tablet be taken with other medications?

EMPAGREAT S 25MG Tablet can interact with other medications. Inform your doctor about all medicines, supplements, or herbal products you are taking.

• Diuretics (water pills): Concomitant use may increase the risk of dehydration or low blood pressure.
• Insulin and sulfonylureas (e.g., glimepiride): Taking these with EMPAGREAT S 25MG Tablet can increase the risk of low blood sugar (hypoglycemia). Your doctor may need to adjust the dosage of these medicines.
• Antibiotics like rifampin: May reduce the effectiveness of sitagliptin.
• Corticosteroids (e.g., prednisone) and sympathomimetics (e.g., epinephrine, albuterol): These can make blood sugar harder to control.
• ACE Inhibitors & ARBs: Can enhance blood pressure-lowering effects.
• Nonsteroidal Anti-Inflammatory Drugs (NSAIDs): May impact kidney function.

What precautions should be taken while using EMPAGREAT S 25MG Tablet?

Before taking EMPAGREAT S 25MG Tablet, inform your doctor if you have a history of kidney or liver problems, urinary tract infections, or heart conditions. It is not recommended for individuals with type 1 diabetes or a history of diabetic ketoacidosis. Use with caution if you are elderly, dehydrated, or taking diuretics, as it may increase the risk of low blood pressure. Maintain good personal hygiene to help prevent genital and urinary tract infections. Alcohol consumption should be avoided or limited, as it can cause fluctuations in blood sugar levels and increase the risk of dehydration and other side effects. Stay well-hydrated by drinking plenty of water.

What happens if a dose of EMPAGREAT S 25MG Tablet is missed?

If you miss a dose of EMPAGREAT S 25MG Tablet, take it as soon as you remember. However, if it is almost time for your next scheduled dose (typically less than 12 hours away), skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one.

How should EMPAGREAT S 25MG Tablet be stored?

EMPAGREAT S 25MG Tablet should be stored in a closed container at room temperature, typically below 30°C. Keep it away from heat, moisture, and direct light, and out of the reach of children.