Dapanorm Gm 1

DAPANORM GM 1

DAPANORM GM 1 (often seen as Dapanorm GM 1 Forte or Dapanorm GM 1 Tablet ER) is a combination medication manufactured by Alkem Laboratories Ltd. used in the management of Type 2 Diabetes Mellitus.

• Composition: Each tablet typically contains Dapagliflozin (10 mg), Glimepiride (1 mg), and Metformin (500 mg or 1000 mg as Metformin Hydrochloride).

  • Dapagliflozin belongs to the class of sodium-glucose cotransporter-2 (SGLT2) inhibitors, which helps remove excess sugar from the body via urine.
  • Glimepiride is a sulfonylurea that stimulates the pancreas to produce more insulin.
  • Metformin is a biguanide that reduces sugar production by the liver and improves the body's response to insulin.

• Uses: This medicine is prescribed for adults with Type 2 Diabetes Mellitus to control high blood sugar levels when diet and exercise, or dual therapy, are insufficient. It helps improve glycemic control and reduces the risk of serious complications associated with diabetes.

• Dosage and Administration: DAPANORM GM 1 should be taken orally as prescribed by a doctor, usually once daily with food, preferably with the first meal of the day, to minimize gastrointestinal upset and the risk of low blood sugar. The tablet should be swallowed whole with water and not crushed, broken, or chewed.

• Side Effects: Common side effects may include:

  • Low blood sugar (hypoglycemia), which can manifest as sweating, shakiness, dizziness, or confusion.
  • Gastrointestinal issues like nausea, vomiting, abdominal pain, and diarrhea.
  • Headache.
  • Genital or urinary tract infections.
  • Increased urination. Serious but less common side effects can include lactic acidosis (due to metformin accumulation), especially in individuals with kidney or liver impairment.

• Precautions:

  • Not recommended for individuals with Type 1 diabetes, severe kidney or liver disease, bladder cancer, or severe heart failure.
  • Avoid during the second and third trimesters of pregnancy and generally not recommended for breastfeeding mothers.
  • Alcohol consumption should be avoided as it increases the risk of hypoglycemia and lactic acidosis.
  • Caution is advised if taking diuretics, insulin, or other insulin secretagogues due to potential drug interactions and risk of hypoglycemia or dehydration.
  • Regular monitoring of blood sugar levels and kidney function is advised during treatment.

• Storage: Store in a cool and dry place, away from direct sunlight, typically between 10ºC and 25ºC or below 30ºC. Keep out of the sight and reach of children.

DAPANORM GM 1, manufactured by Alkem Laboratories Ltd, is a combination medication used to manage Type 2 Diabetes Mellitus. It contains three active ingredients: Dapagliflozin, Metformin, and Glimepiride.

Here are some frequently asked questions about DAPANORM GM 1:

What is DAPANORM GM 1 used for?

DAPANORM GM 1 is an anti-diabetic medicine primarily used to treat Type 2 Diabetes Mellitus in adults. It helps to control high blood sugar levels, especially when diet and exercise alone, or therapy with single or dual medications, are not sufficient. By managing blood glucose, it helps reduce the risk of serious complications associated with diabetes, such as kidney damage, blindness, and heart disease.

How does DAPANORM GM 1 work?

DAPANORM GM 1 combines three different medications, each working in a distinct way to lower blood sugar:

• Dapagliflozin: This is a sodium-glucose cotransporter-2 (SGLT2) inhibitor that helps the kidneys remove excess sugar from the body through urine.
• Metformin: Belonging to the biguanide class, Metformin works by reducing the production of sugar by cells in the liver and delaying the absorption of sugar from the intestines. It also improves the body's response to insulin.
• Glimepiride: As a sulfonylurea, Glimepiride stimulates the beta cells in the pancreas to produce more insulin, which then helps remove sugar from the blood.

What is the usual dosage?

DAPANORM GM 1 should be taken exactly as prescribed by your doctor. It is typically taken once daily with or without food, preferably with the first meal of the day, to help reduce the risk of stomach upset or low blood sugar. Do not exceed the recommended dose or discontinue the medicine without consulting your doctor.

What are the possible side effects?

Common side effects of DAPANORM GM 1 may include low blood sugar levels (hypoglycemia), nausea, vomiting, abdominal pain, headache, dizziness, diarrhea, genital infections, and urinary tract infections. More serious but rare side effects can include lactic acidosis (a dangerous build-up of acid in the blood) and severe allergic reactions. If any side effects persist or worsen, or if you experience severe symptoms, consult your doctor immediately.

Is it safe during pregnancy or breastfeeding?

DAPANORM GM 1 is generally not recommended during pregnancy, especially during the second and third trimesters, as it may affect kidney development in the unborn baby. There is limited information on its use during breastfeeding, and the active ingredients can pass into breast milk, potentially causing low blood sugar in nursing infants. Therefore, it is important to inform your doctor if you are pregnant, planning pregnancy, or breastfeeding before taking this medication.

Can it be taken with other medications?

DAPANORM GM 1 can interact with other medications. It's crucial to inform your doctor about all medicines, supplements, or herbal products you are currently taking to avoid potential interactions. For instance, taking it with diuretics may increase the risk of dehydration and low blood pressure. Combining it with insulin or other insulin secretagogues can lead to extremely low blood sugar levels. Carbonic anhydrase inhibitors may increase the risk of lactic acidosis when taken with the metformin component.

What precautions should be taken?

Before taking DAPANORM GM 1, inform your doctor if you have any history of kidney disease, liver disease, heart problems, severe infections, or a sulfa allergy. Avoid excessive alcohol consumption while on this medication, as it can increase the risk of hypoglycemia and lactic acidosis. Regular monitoring of blood sugar levels and kidney function is often recommended during therapy. This medicine is not recommended for individuals with Type 1 diabetes or children under 18 years of age.

What happens if a dose is missed?

If you miss a dose of DAPANORM GM 1, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to compensate for the missed one, as this can cause your blood sugar level to drop rapidly.

How should it be stored?

DAPANORM GM 1 should be stored in a cool and dry place, away from direct sunlight. Keep the medicine out of the sight and reach of children. Generally, it should be stored at temperatures between 10ºC to 25ºC or below 30ºC.