Apraize 30 Mg Tablet (10 Tab)

APRAIZE 30 MG TABLET

APRAIZE 30 MG TABLET, manufactured by IPCA LABORATORIES LTD., is a medication prescribed for chronic inflammatory conditions.

• Composition Each tablet contains Apremilast 30mg as its active ingredient. Apremilast is a phosphodiesterase 4 (PDE4) inhibitor that works by blocking the action of certain chemical messengers responsible for inflammation, thereby reducing the signs and symptoms of these conditions.

• Uses APRAIZE 30 MG TABLET is used to treat:

  • Moderate to severe plaque psoriasis, a skin condition characterized by red, scaly, thick, itchy, and painful patches on the skin. It is typically considered when other conventional treatments are ineffective, contraindicated, or poorly tolerated.
  • Active psoriatic arthritis, a type of arthritis that causes joint pain and swelling in people with psoriasis.
  • Oral ulcers associated with Behçet's disease.

• Dosage and Administration APRAIZE 30 MG TABLET is for oral administration and can be taken with or without food. Tablets should be swallowed whole with water and not chewed, crushed, or broken. It is important to take the medication regularly at the same time each day as prescribed by a healthcare professional.

  • Adults: For moderate to severe plaque psoriasis, the typical starting dosage is 30 mg taken orally twice daily for the first 5 days, followed by a maintenance dosage of 30 mg orally twice daily. For active psoriatic arthritis, the recommended dosage is 30 mg orally twice daily. The doctor will usually start with a low dose and gradually increase it over the first 6 days.
  • Pediatrics: APRAIZE 30 MG TABLET is generally not recommended for use in patients 17 years and younger as safety and efficacy have not been well-established in this age group.

• Side Effects Common side effects may include:

  • Nausea, diarrhea, vomiting
  • Headache
  • Upper respiratory tract infection (URTI), cough, runny nose, sore throat
  • Back pain
  • Loss of appetite, indigestion, weight loss
  • Sleep disturbances, feeling tired

  More serious, though less common, side effects include depression and suicidal thoughts. Persistent or worsening symptoms should be reported to a doctor.

• Precautions

  • Medical History: Inform your doctor about any history of mental health problems, such as depression or suicidal thoughts, as APRAIZE 30 MG TABLET may potentially worsen these conditions. If such symptoms develop, seek medical advice immediately.
  • Kidney and Liver Conditions: Use with caution in patients with severe kidney disease, as dose adjustment may be required. It is generally safe for patients with liver disease if prescribed.
  • Pregnancy and Breastfeeding: APRAIZE 30 MG TABLET may be unsafe to use during pregnancy. Pregnant women or those of childbearing age should consult their doctor regarding risks and birth control methods. Information on use during breastfeeding is not available, so consult your doctor.
  • Drug Interactions: Disclose all current medications (prescription, over-the-counter, herbal, supplements) to your doctor to prevent potential drug interactions.
  • Weight Monitoring: Regular monitoring of weight is advisable as weight loss is a potential side effect. Inform your doctor if you experience unexplained or significant weight loss.
  • Gastrointestinal Issues: If severe diarrhea, nausea, or vomiting occurs, the medication should be stopped, and a doctor consulted.
  • Alcohol and Driving: Caution is advised when consuming alcohol. If you experience dizziness or drowsiness, avoid driving or operating machinery.
  • Lactose Intolerance: Consult your doctor if you have any sugar intolerance.

• Storage Store APRAIZE 30 MG TABLET below 30°C in a clean, dry place, protected from moisture, sunlight, and heat. Keep out of sight and reach of children.

Frequently Asked Questions about APRAIZE 30 MG TABLET

What is APRAIZE 30 MG TABLET used for?

APRAIZE 30 MG TABLET is primarily used to treat moderate to severe plaque psoriasis, which is a skin condition characterized by red, scaly, thick, itchy, and painful patches on the skin. It is also used for psoriatic arthritis, a type of arthritis that affects some people with psoriasis, causing joint pain and swelling. Additionally, it can be used to treat oral ulcers associated with Behcet's disease. This medicine is often prescribed when other conventional treatments are not effective or cannot be used due to side effects.

How does APRAIZE 30 MG TABLET work?

APRAIZE 30 MG TABLET contains Apremilast, which is a phosphodiesterase 4 (PDE4) inhibitor. It works by blocking the action of certain chemical messengers in the body that are responsible for inflammation associated with psoriatic arthritis and psoriasis. By reducing these inflammatory mediators, it helps to alleviate the signs and symptoms of these conditions, such as joint pain, stiffness, swelling, and skin plaques.

What is the usual dosage of APRAIZE 30 MG TABLET?

For adults, the typical starting dosage for moderate to severe plaque psoriasis is 30 mg taken orally twice daily for the first 5 days. This is followed by a maintenance dosage of 30 mg taken orally twice daily. For active psoriatic arthritis, the recommended dosage is also 30 mg taken orally twice daily. It's crucial to follow your doctor's recommendations precisely, as the dose may be gradually increased by your doctor after an initial period. The tablets should be swallowed whole with a glass of water and not crushed, chewed, or broken. It can be taken with or without food. APRAIZE 30 MG TABLET is generally not recommended for children and adolescents under 17 years of age.

What are the possible side effects of APRAIZE 30 MG TABLET?

Common side effects include diarrhea, nausea, vomiting, headache, and upper respiratory tract infection. Other possible side effects may include weight loss, back pain, indigestion, cough, feeling tired, stomach pain, loss of appetite, and difficulty sleeping. Most of these side effects are usually mild and tend to improve over time as your body adjusts to the medication. If side effects are persistent or worsen, you should inform your doctor. This medication may also cause depression and suicidal thoughts, especially in patients with a history of depression, and unexplained weight loss should be reported to a doctor immediately.

Is APRAIZE 30 MG TABLET safe during pregnancy or breastfeeding?

APRAIZE 30 MG TABLET is generally considered unsafe during pregnancy and should not be taken by pregnant women. If you are a woman of childbearing age, discuss birth control methods with your physician due to potential hazards to an unborn baby. If you become pregnant while taking this medication, inform your doctor immediately. It is not known whether APRAIZE 30 MG TABLET passes into breast milk, and it is generally not recommended for use while breastfeeding as it may harm the newborn. Always consult your doctor before taking this medicine if you are pregnant, planning a pregnancy, or breastfeeding.

Can APRAIZE 30 MG TABLET be taken with other medications?

It is crucial to inform your doctor about all the medications, supplements, and herbal remedies you are currently taking to avoid potential drug interactions. APRAIZE 30 MG TABLET may interact with certain medications such as rifampicin (for tuberculosis), phenytoin, phenobarbital, and carbamazepine (for epilepsy or fits), and St. John's Wort (a herbal medicine). Strong CYP3A4 inducers (like rifampin, phenytoin, and carbamazepine) may decrease apremilast levels, reducing its effectiveness, while strong CYP3A4 inhibitors (like ketoconazole, itraconazole, and clarithromycin) may increase apremilast levels, potentially leading to side effects.

What precautions should be taken with APRAIZE 30 MG TABLET?

Before starting APRAIZE 30 MG TABLET, inform your doctor if you have any history of depression or suicidal thoughts, severe kidney problems, or if you are underweight. Regular monitoring of your weight is advisable, as the medication can cause weight loss. If you experience severe diarrhea, nausea, or vomiting, or any changes in behavior or mood, including sleeplessness or depressive mood, contact your doctor immediately. This medicine is not recommended for individuals under 17 years of age. While there's no known interaction with alcohol, it's advisable to consult your doctor if you consume alcohol regularly. Avoid consuming grapefruit or grapefruit juice, as it may interfere with the metabolism of the medication.

What happens if a dose is missed?

If you miss a dose of APRAIZE 30 MG TABLET, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to compensate for the missed one.

How should APRAIZE 30 MG TABLET be stored?

APRAIZE 30 MG TABLET should be stored in a cool and dry place, away from direct sunlight, moisture, and heat. It should be kept out of sight and reach of children and pets. The recommended storage temperature is below 30°C, or between 10°C to 25°C. Any unused medicine should be discarded properly.