RABIVAX-S INJ

Name

• Common Name: Rabies Vaccine (Inactivated)
• Brand Name: RABIVAX-S INJ

Composition

• Active Ingredient: Purified Vero cell rabies vaccine (Inactivated rabies virus)
• Formulation: Each dose contains inactivated rabies virus grown on Vero cells, presented as a lyophilized powder for reconstitution with sterile water.

Uses

• Post-exposure prophylaxis (PEP): For individuals exposed or potentially exposed to rabies (e.g., animal bites or scratches).
• Pre-exposure prophylaxis (PrEP): For individuals at high risk of rabies exposure, such as veterinarians, animal handlers, and laboratory personnel.

Dosage and Administration

• Route: Intramuscular injection, typically in the deltoid muscle for adults and older children, or the anterolateral thigh for infants and young children.
• Post-exposure:
  • Without prior vaccination: 1 mL administered on days 0, 3, 7, and 14.
  • With prior vaccination: 1 mL administered on days 0 and 3.
• Pre-exposure: 1 mL on days 0, 7, and 21 or 28.
• Reconstitution: Mix the lyophilized powder with the provided diluent before administration.

Side Effects

• Common:
  • Pain, redness, or swelling at the injection site
  • Fever
  • Headache
  • Muscle aches
• Serious (rare):
  • Allergic reactions (rash, itching, difficulty breathing)
  • Neurological symptoms (very rare)

Precautions

• Do not administer intravenously.
• Use with caution in individuals with a history of severe allergic reactions to vaccine components.
• Immunosuppressed or immunocompromised patients may have a reduced immune response.
• Inform the healthcare provider of any current medications or illnesses.
• Co-administration with rabies immunoglobulin is recommended for certain post-exposure cases.

Storage

• Store in a refrigerator at 2°C to 8°C.
• Do not freeze.
• Protect from light.
• Use immediately after reconstitution; discard any unused portion.

What is RABIVAX-S Injection used for?

RABIVAX-S Injection is a vaccine used to prevent rabies infection in people who have been exposed to the rabies virus (post-exposure prophylaxis) or as a preventive measure for those at high risk of exposure (pre-exposure prophylaxis).

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How does RABIVAX-S work?

RABIVAX-S contains an inactivated (killed) rabies virus. It stimulates the body’s immune system to produce antibodies against rabies, providing protection if you are exposed to the virus.

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What is the usual dosage and schedule for RABIVAX-S?

For post-exposure prophylaxis (after a potential rabies exposure), the vaccine is usually given as a series of injections over several days, often on days 0, 3, 7, and 14. For pre-exposure prophylaxis (before exposure), the schedule is typically on days 0, 7, and 21 or 28. The exact schedule may vary based on guidelines and individual risk factors.

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What are the possible side effects of RABIVAX-S?

Common side effects include pain, redness, or swelling at the injection site, fever, headache, muscle aches, and mild fatigue. Rarely, allergic reactions can occur.

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Is RABIVAX-S safe during pregnancy or breastfeeding?

RABIVAX-S can be given during pregnancy or breastfeeding if the risk of rabies exposure is significant, as rabies is a life-threatening disease. The benefits of vaccination outweigh any potential risk in such circumstances.

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Can RABIVAX-S be taken with other medications or vaccines?

Yes, RABIVAX-S can generally be given with other vaccines or medications, but inform your healthcare provider about all medicines, vaccines, or supplements you are taking to avoid potential interactions.

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What precautions should be taken while receiving RABIVAX-S?

Inform your doctor if you have a history of severe allergic reactions to previous rabies vaccines or any components of RABIVAX-S. Also, share if you have any immune system disorders, as you may need extra monitoring.

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What should I do if I miss a dose of RABIVAX-S?

Contact your healthcare provider as soon as possible to reschedule the missed dose. It is important to complete the full vaccination schedule for effective protection.

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How should RABIVAX-S be stored?

RABIVAX-S should be stored in a refrigerator at 2°C to 8°C (36°F to 46°F). It should not be frozen. The vaccine should be administered by a healthcare professional.

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Who should not receive RABIVAX-S?

People with a known severe allergy to any component of the vaccine should not receive RABIVAX-S. In all other cases, especially where there is a risk of rabies, the vaccine is generally recommended due to the seriousness of the disease.