Jalra M 50/1000 Mg Tablet (15 Tab)

JALRA M 50/1000 MG Tablet

JALRA M 50/1000 MG Tablet is a combination oral antidiabetic medication used to manage blood sugar levels in adults with Type 2 Diabetes Mellitus. It helps improve glycemic control when diet and exercise alone, or monotherapy with either vildagliptin or metformin, are insufficient. This medication works to prevent serious long-term complications associated with diabetes, such as kidney damage, blindness, nerve problems, and cardiovascular issues like heart attack and stroke.

Composition

JALRA M 50/1000 MG Tablet contains two active ingredients:

• Vildagliptin: 50 mg
• Metformin Hydrochloride: 1000 mg (equivalent to 780 mg metformin)

Uses

JALRA M 50/1000 MG Tablet is primarily prescribed for:

• Type 2 Diabetes Mellitus: To control high blood sugar levels in adults.
• Diabetes Management: As an adjunct to diet and exercise when metformin or vildagliptin alone is not providing adequate blood sugar control.
• Cardiovascular Health: By improving blood sugar control, it contributes to better cardiovascular health and reduces the risk of heart disease in diabetic patients.
• Polycystic Ovary Syndrome (PCOS): (Less commonly, may be used for PCOS).

Dosage and Administration

• JALRA M 50/1000 MG Tablet should be taken orally, swallowed whole with a glass of water, preferably with or immediately after food to minimize gastrointestinal upset.
• The typical recommended dose is one tablet (50 mg/1000 mg) twice daily, generally once in the morning and once in the evening.
• Your doctor will determine the appropriate dosage based on your condition and response to treatment. Do not exceed the maximum recommended daily dose of 100 mg Vildagliptin plus 2000 mg Metformin HCl.
• It is crucial to continue following dietary and exercise recommendations while on this medication.
• Do not crush, chew, or break the tablet. Do not skip meals.
• This medicine is not recommended for patients under 18 years of age.

Side Effects

Common Side Effects:

• Hypoglycemia (low blood sugar), characterized by dizziness, sweating, hunger pangs, dry mouth, and skin changes
• Changes in taste, nausea, diarrhoea, stomach pain/discomfort, vomiting, flatulence
• Headache, dizziness
• Upper respiratory tract infections, nasopharyngitis

Serious Side Effects (Rare):

• Lactic Acidosis: A rare but serious condition that can occur due to metformin accumulation, presenting with symptoms like muscle pain or weakness, difficulty breathing, unusual tiredness, feeling cold in arms and legs, persistent nausea, vomiting, stomach pain, or slow heart rate.
• Severe allergic reactions (rash, itching, difficulty breathing, swelling).
• Bullous pemphigoid (a serious skin reaction).

Precautions

• Contraindications: Do not take JALRA M if you have a known allergy to vildagliptin, metformin, or any of its components. It is also contraindicated in patients with Type 1 diabetes, diabetic ketoacidosis, severe kidney or liver disease, congestive heart failure, acute myocardial infarction, septicaemia, or acute/chronic metabolic acidosis.
• Alcohol Consumption: Avoid or limit alcohol intake as it can increase the risk of hypoglycemia and lactic acidosis.
• Pregnancy and Breastfeeding: Consult your doctor before using this medication if you are pregnant, planning to become pregnant, or breastfeeding, as it may be unsafe.
• Kidney and Liver Function: Regular monitoring of kidney and liver function is advised, and caution is needed in patients with pre-existing kidney or liver conditions. Dose adjustments or avoidance may be necessary.
• Hypoglycemia Risk: The risk of low blood sugar increases when JALRA M is used in combination with other diabetes medicines like insulin or sulfonylureas. It is advisable to carry a form of sugar to treat unexpected hypoglycemia.
• Discontinuation: Do not stop taking JALRA M abruptly without consulting your doctor, as this can lead to an increase in blood sugar levels and potential complications.
• Drug Interactions: Inform your healthcare provider about all prescription, over-the-counter, herbal, and vitamin supplements you are currently taking, as some medications can interact with JALRA M.
• Radiologic Studies: Temporarily discontinue JALRA M if you are undergoing radiologic studies involving intravascular administration of iodinated contrast materials.

Storage

• Store JALRA M 50/1000 MG Tablet in a cool and dry place, ideally at room temperature (15-25°C or below 30°C).
• Protect the medicine from direct sunlight and moisture.
• Keep it in its original packaging until use.
• Keep out of the sight and reach of children and pets.
• Always check the expiry date before use and discard any expired medicine responsibly.

What is JALRA M 50/1000 MG TABLET used for?

JALRA M 50/1000 MG TABLET is primarily used to manage Type 2 diabetes mellitus in adults. It is prescribed when diet and exercise alone, or other single antidiabetic medications, are not sufficient to control blood sugar levels. This medicine helps improve blood sugar control, which in turn can prevent serious complications of diabetes such as kidney damage, eyesight loss, nerve problems, and may reduce the risk of heart attack or stroke.

How does JALRA M 50/1000 MG TABLET work?

JALRA M 50/1000 MG TABLET is a combination of two active ingredients: Vildagliptin (50 mg) and Metformin (1000 mg).

• Vildagliptin works by inhibiting an enzyme called DPP-4, which increases the levels of natural hormones called incretins. These incretins help the pancreas produce more insulin when blood sugar levels are high and decrease the production of glucagon, a hormone that raises blood sugar.
• Metformin works by lowering the amount of glucose produced by the liver, reducing the absorption of glucose from the intestines, and increasing the body's sensitivity to insulin, allowing cells to utilize more circulating blood glucose. Together, these actions provide better control of blood sugar levels.

What is the usual dosage of JALRA M 50/1000 MG TABLET?

The usual dosage of JALRA M 50/1000 MG TABLET is typically one tablet once or twice daily, as directed by your doctor. It should preferably be taken with food to minimize gastrointestinal side effects. Your doctor will determine the appropriate dose based on your condition, blood sugar levels, and response to the medicine. Do not crush, chew, or break the tablet.

What are the possible side effects of JALRA M 50/1000 MG TABLET?

Common side effects may include:

• Hypoglycemia (low blood sugar), especially when used with other antidiabetic drugs like sulfonylureas. Symptoms can include dizziness, sweating, hunger, dry mouth, headache, and palpitations.
• Gastrointestinal issues such as nausea, vomiting, diarrhea, stomach pain, or flatulence.
• Headache
• Upper respiratory tract infection or nasopharyngitis.
• Fatigue or weakness.

Serious side effects, though rare, can include lactic acidosis (symptoms like muscle pain or weakness, difficulty breathing, unusual tiredness, and feeling cold) and pancreatitis (severe and persistent abdominal pain with or without nausea or vomiting). If you experience any severe or persistent side effects, contact your doctor immediately.

Is JALRA M 50/1000 MG TABLET safe during pregnancy or breastfeeding?

JALRA M 50/1000 MG TABLET is generally not recommended during pregnancy unless clearly advised by a doctor after evaluating the potential risks and benefits. For breastfeeding women, it is probably unsafe and generally contraindicated; a thorough consultation with your doctor is necessary to decide whether to continue nursing or discontinue the medication.

Can it be taken with other medications?

JALRA M 50/1000 MG TABLET can interact with certain medications, potentially affecting its efficacy or increasing the risk of side effects. It's crucial to inform your doctor about all medicines you are currently taking, including prescription, over-the-counter drugs, herbal supplements, and vitamins. Some medications that may interact include:

• Cationic medicines like amiloride, digoxin, and morphine.
• Diuretics (e.g., chlorthiazide, hydrochlorothiazide, furosemide).
• Corticosteroids (e.g., dexamethasone, prednisolone).
• Phenothiazines and thyroid products.
• Carbonic anhydrase inhibitors (e.g., topiramate, acetazolamide).
• NSAIDs (e.g., ibuprofen, celecoxib).
• Angiotensin-converting enzyme (ACE) inhibitors (e.g., enalapril, lisinopril).
• Iodinated contrast agents, as they may increase the risk of metformin-induced lactic acidosis.

What precautions should be taken?

Several precautions should be taken:

• Kidney and Liver Conditions: JALRA M should be used with caution in patients with kidney disease and is contraindicated in severe kidney or liver impairment due to the increased risk of metformin accumulation and lactic acidosis.
• Alcohol Consumption: Avoid excessive alcohol intake while taking this medicine, as it can increase the risk of lactic acidosis and hypoglycemia.
• Heart Conditions: Use with caution in patients with congestive heart failure.
• Monitoring: Regular monitoring of blood sugar levels, kidney function, and liver enzymes is essential during treatment.
• Hypoglycemia: Be aware of the symptoms of low blood sugar and carry a source of sugar with you.
• Allergies: Do not take if you are allergic to vildagliptin, metformin, or any other ingredients of the tablet.
• Driving: Your ability to drive may be affected if your blood sugar is too low or too high; exercise caution.

What happens if a dose is missed?

If you miss a dose of JALRA M 50/1000 MG TABLET, take it as soon as you remember, unless it is almost time for your next scheduled dose. In that case, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a forgotten dose.

How should it be stored?

JALRA M 50/1000 MG TABLET should be stored in a cool and dry place, ideally at room temperature (below 25°C or 10ºC to 25ºC). Protect it from direct sunlight, moisture, and heat. Keep the medication in its original packaging and out of the sight and reach of children and pets. Always check the expiry date and discard any expired medicine.