Pramipex Er 0.75 Mg Tablet (10 Tab)

Pramipex ER 0.75 MG Tablet

Pramipex ER 0.75 MG Tablet, manufactured by SUN PHARMA LABORATORIES LTD., is an extended-release medication primarily used to manage symptoms of Parkinson's disease and Restless Legs Syndrome (RLS). This medication works as a dopamine agonist, mimicking the effects of dopamine in the brain, a natural chemical crucial for controlling movement.

Composition

The active ingredient in Pramipex ER 0.75 MG Tablet is Pramipexole (0.75 mg).

Uses

Pramipex ER 0.75 MG Tablet is prescribed for:

• Parkinson's Disease: It helps alleviate symptoms such as tremors, stiffness, muscle spasms, and poor muscle control by stimulating dopamine receptors in the brain.
• Restless Legs Syndrome (RLS): It is used to treat moderate to severe RLS (also known as Willis-Ekbom disease), a neurological disorder causing uncomfortable sensations and an irresistible urge to move the legs.

Dosage and Administration

Pramipex ER 0.75 MG Tablet is an extended-release formulation taken orally once daily, with or without food. It is crucial to swallow the tablet whole and not to chew, crush, or divide it. For RLS, it is often recommended to take the medicine 2 to 3 hours before bedtime. Dosage adjustments should be made gradually under medical supervision, typically not more frequently than every 5 to 7 days for Parkinson's disease. Sudden discontinuation of the medication should be avoided, as it may lead to withdrawal symptoms.

Side Effects

Common side effects may include:

• Nausea, constipation, dry mouth
• Dizziness, drowsiness, fatigue
• Hallucinations (seeing, hearing, or feeling things that are not there)
• Unusual body movements (dyskinesia)
• Peripheral edema (leg swelling due to fluid overload)

Serious side effects to report to a healthcare professional immediately include:

• Sudden onset of sleep during daily activities
• Orthostatic hypotension (sudden drop in blood pressure upon standing, leading to dizziness or fainting)
• Unusual changes in thoughts or behavior, such as increased gambling urges, spending money, binge eating, or increased sex drive.
• Unexplained muscle pain, tenderness, or weakness (rhabdomyolysis)
• Posture changes you cannot control, such as bending forward at the neck or waist.
• Severe allergic reactions (hives, difficulty breathing, swelling of face, lips, tongue, or throat)

Precautions

• Driving and Operating Machinery: This medication can cause sudden sleepiness or dizziness; avoid activities requiring alertness until you know how it affects you.
• Alcohol and CNS Depressants: Avoid alcohol and other CNS depressants as they can increase drowsiness and dizziness.
• Renal Impairment: Use with caution in patients with kidney conditions, as dose adjustment may be necessary.
• Orthostatic Hypotension: Monitor blood pressure closely, especially during dose escalation.
• Hallucinations and Psychotic-like Behaviors: More common in elderly patients.
• Interactions: Inform your doctor about all medications, vitamins, and herbal supplements you are taking, especially antipsychotics, metoclopramide, and other drugs causing drowsiness.

Storage

Store Pramipex ER 0.75 MG Tablet at room temperature, between 68ºF to 77ºF (20ºC to 25ºC), away from moisture and heat. Keep out of reach of children.

What is Pramipex ER 0.75 mg Tablet used for?

Pramipex ER 0.75 mg Tablet is primarily used to treat the symptoms of Parkinson's disease in adults, helping to manage tremors, stiffness, slow movements, and poor muscle control. It may also be used to treat moderate to severe Willis-Ekbom disease, also known as restless legs syndrome (RLS), which causes an uncontrollable urge to move the legs.

How does Pramipex ER 0.75 mg Tablet work?

Pramipex ER 0.75 mg Tablet contains pramipexole, which is a dopamine agonist. It works by mimicking the action of dopamine, a natural chemical messenger in the brain that is essential for controlling body movement. By stimulating dopamine receptors in the brain, it helps restore the balance of dopamine activity, thereby reducing the symptoms associated with Parkinson's disease and restless legs syndrome.

What is the usual dosage for Pramipex ER 0.75 mg Tablet?

Pramipex ER 0.75 mg is an extended-release tablet typically taken once daily. It should be swallowed whole with water, without crushing, chewing, or breaking it. It can be taken with or without food; taking it with food may help reduce nausea. The initial dose for pramipexole extended-release is usually 0.375 mg once daily, which may be gradually increased by your doctor not more frequently than every 5 to 7 days, up to a maximum recommended dose of 4.5 mg per day, based on your response and tolerability.

What are the possible side effects of Pramipex ER 0.75 mg Tablet?

Common side effects include sleepiness, nausea, constipation, dizziness, fatigue, dry mouth, headache, vomiting, and swelling in the legs or hands (peripheral oedema). More serious side effects can include hallucinations (seeing or hearing things that are not real), confusion, unusual strong urges (such as increased gambling or sexual urges), sudden sleep attacks, and orthostatic hypotension (a sudden drop in blood pressure when standing up). If you experience any severe or persistent side effects, you should consult your doctor.

Is Pramipex ER 0.75 mg Tablet safe during pregnancy or breastfeeding?

Pregnancy: Pramipex ER 0.75 mg Tablet should be used with caution during pregnancy. There is limited information on its safety in human pregnancy, and animal studies have shown potential harmful effects on the developing baby. Your doctor will weigh the benefits against potential risks before prescribing it.

Breastfeeding: This medicine is probably unsafe during breastfeeding. It may reduce breast milk production and can pass into breast milk. If taking Pramipex ER 0.75 mg Tablet is unavoidable, breastfeeding should be stopped. Consult your doctor for guidance.

Can Pramipex ER 0.75 mg Tablet be taken with other medications?

Pramipex ER 0.75 mg Tablet can interact with other medications. It is important to inform your doctor about all prescription and non-prescription drugs, supplements, and herbal products you are taking. Avoid or use with caution with alcohol and other medications that cause drowsiness (e.g., opioid pain relievers, sleeping pills, antihistamines). Antipsychotics and metoclopramide may reduce its effectiveness, while cimetidine can increase pramipexole levels in the body. If taken with levodopa, there is an increased risk of hallucinations and involuntary movements (dyskinesia).

What precautions should be taken while taking Pramipex ER 0.75 mg Tablet?

Do not drive or operate heavy machinery if you experience drowsiness, dizziness, or hallucinations, as this medication can impair your reactions and may cause sudden sleep attacks without warning. You should also rise slowly from a sitting or lying position to prevent dizziness due to a sudden drop in blood pressure (orthostatic hypotension). Do not stop taking Pramipex ER 0.75 mg Tablet suddenly, as this can lead to withdrawal symptoms such as anxiety, depression, confusion, fever, or muscle stiffness; your doctor will advise on a gradual tapering of the dose if discontinuation is necessary. Report any unusual strong urges or compulsive behaviors to your doctor. Caution is advised for individuals with kidney or heart problems, mental health conditions, or vision impairment. This medication is not recommended for children under 18.

What happens if a dose of Pramipex ER 0.75 mg Tablet is missed?

If you miss a dose of Pramipex ER 0.75 mg Tablet, take it as soon as you remember. However, if more than 12 hours have passed since your regular dosing time, skip the missed dose and continue with your next scheduled dose. Do not take a double dose to make up for a missed one. If there has been a significant interruption in your therapy, your doctor may need to re-adjust your dosage.

How should Pramipex ER 0.75 mg Tablet be stored?

Pramipex ER 0.75 mg Tablet should be stored at room temperature, away from light, moisture, and heat. Keep the medication out of the reach of children and pets, and avoid storing it in the bathroom.