Endogest Sr 200 Mg Tablet (10 Tab)

ENDOGEST SR 200 MG TABLET (10 TAB) by CIPLA LTD.

This medication is a hormonal drug primarily used to address various conditions related to hormonal imbalances in women. It contains progesterone in a sustained-release formulation.

• Name:

  • Brand Name: ENDOGEST SR 200 MG TABLET
  • Common Name: Progesterone (sustained-release)

• Composition:

  • Each tablet contains Progesterone (Natural Micronized) 200 mg in a sustained-release (SR) formulation.

• Uses: ENDOGEST SR 200 MG TABLET is prescribed for a range of conditions related to female hormonal imbalances and reproductive health:

  • Hormone Replacement Therapy (HRT): Used in conjunction with estrogen to alleviate menopausal symptoms such as hot flashes, vaginal dryness, and mood swings, and to prevent endometrial hyperplasia (thickening of the uterus lining).
  • Menstrual Irregularities: Treats amenorrhea (absence of menstrual periods), irregular periods, and dysfunctional uterine bleeding.
  • Female Infertility: Supports pregnancy, aids in the maintenance of pregnancy, prevents threatened abortion, and reduces the risk of preterm labor. It is also used for luteal phase support during assisted reproductive technologies like IVF.
  • Other uses: Management of premenstrual syndrome (PMS).

• Dosage and Administration:

  • The typical dosage varies based on the condition being treated and is determined by a physician.
  • Tablets should be swallowed whole with a glass of water; they should not be crushed, chewed, or broken, as this can affect the sustained release of the medicine.
  • It is generally recommended to take the tablet with food to optimize absorption and minimize potential stomach upset, or at bedtime to reduce the risk of dizziness or drowsiness.
  • For best results, take the medicine around the same time daily.

• Side Effects:

  • Common Side Effects: Headache, breast pain and tenderness, irregular vaginal bleeding or spotting, stomach or abdominal cramps, bloating, nausea, vomiting, constipation, hair loss, edema (fluid retention), vaginal discharge, dizziness, drowsiness, mood changes, joint pain, and hot flashes. These often resolve as the body adjusts.
  • Serious Side Effects (Seek immediate medical attention): Signs of liver disease (e.g., yellow skin/eyes), severely high blood pressure, new migraine-like headaches, sudden vision changes, bulging eyes, eye swelling, retinal vascular lesions, and signs of a blood clot (e.g., painful swelling and redness of legs, sudden chest pain, trouble breathing).

• Precautions:

  • Contraindications: Avoid if allergic to soy, progesterone, or any other components. Not recommended for individuals with breast cancer, unexplained vaginal bleeding, blood clots or clotting disorders, severe liver disease, porphyria, or cerebral hemorrhage.
  • Medical Conditions: Use with caution in patients with a history of depression, diabetes, high blood pressure, migraine or severe headaches, gallstones, asthma, fits, or systemic lupus erythematosus.
  • Pregnancy and Breastfeeding: While often used to support pregnancy under medical supervision, consult a doctor before use if pregnant or breastfeeding.
  • Driving and Machinery: May cause drowsiness or dizziness; avoid driving or operating machinery if affected.
  • Alcohol: Avoid consuming alcohol as it may intensify certain side effects like dizziness.
  • Drug Interactions: May interact with CYP3A4 enzyme inducers (e.g., rifampin) or inhibitors (e.g., ketoconazole), and estrogen-containing medicines.
  • Effective birth control methods should be used if not planning pregnancy.

• Storage:

  • Store in a cool and dry place, away from direct sunlight.
  • Keep out of reach and sight of children.
  • Maintain at room temperature, ideally between 10ºC to 25ºC or below 30ºC.

What is ENDOGEST SR 200 MG TABLET used for?

ENDOGEST SR 200 MG TABLET is primarily used to address various conditions related to hormonal imbalances in women. It is frequently prescribed for hormone replacement therapy (HRT) to manage menopause symptoms like hot flashes, night sweats, and mood swings. It also treats amenorrhoea (absence of menstrual periods), prevents endometrial hyperplasia (thickened uterus lining), manages menstrual irregularities, and addresses abnormal uterine bleeding. Additionally, it supports female infertility, early pregnancy (such as threatened abortion), and helps prevent preterm labor, particularly in women undergoing assisted reproductive technologies like IVF.

How does ENDOGEST SR 200 MG TABLET work?

This medicine contains progesterone, a natural female sex hormone. It works by supplementing or replacing the body's progesterone levels. Progesterone plays a crucial role in regulating the menstrual cycle and preparing the uterus lining (endometrium) for the implantation of a fertilized egg and maintaining a healthy pregnancy. In HRT, it helps balance estrogen levels to relieve menopausal symptoms and protect the uterus from the adverse effects of estrogen alone.

What is the usual dosage for ENDOGEST SR 200 MG TABLET?

The dosage varies depending on the specific condition being treated, its severity, and individual patient response, as determined by a physician. It is typically taken orally, once daily, and should be swallowed whole with a glass of water, without crushing, chewing, or breaking it. Some sources recommend taking it with food for optimal absorption and to minimize stomach upset, while others state it can be taken with or without food. For best results, it's advised to take the tablet around the same time daily.

What are the possible side effects of ENDOGEST SR 200 MG TABLET?

Common side effects include dizziness, drowsiness, headache, mood changes, diarrhea, vaginal discharge, joint pain, hot flashes, constipation, nausea, vomiting, abdominal cramps, breast pain or tenderness, irregular vaginal bleeding or spotting, hair loss, fluid retention, and vaginal yeast infection. More serious side effects, though less common, can include signs of liver disease (e.g., yellow skin), severely high blood pressure, migraine-like headaches, sudden vision changes, bulging eyes, or signs of a blood clot (e.g., painful leg swelling, chest pain, difficulty breathing). Most common side effects are temporary and often resolve as the body adjusts to the medication.

Is ENDOGEST SR 200 MG TABLET safe during pregnancy or breastfeeding?

During pregnancy, ENDOGEST SR 200 MG TABLET may be prescribed to support the early stages of pregnancy and fetal growth, especially in cases of infertility or threatened miscarriage, if deemed safe by a doctor. However, some information also advises against taking it if pregnant as it may harm the unborn baby, and recommends using birth control while on the medication. Therefore, it is crucial to consult your doctor before taking this medicine if you are pregnant or planning a pregnancy.

While breastfeeding, components of ENDOGEST SR 200 MG TABLET may pass into breast milk, and its effect on breastfed infants is unknown. Some sources advise consulting a doctor, while others state it is not recommended or contraindicated for breastfeeding women. Always consult a healthcare professional before using this medicine while breastfeeding.

Can ENDOGEST SR 200 MG TABLET be taken with other medications?

Yes, ENDOGEST SR 200 MG TABLET can interact with other medications. For example, medicines that induce the CYP3A4 enzyme, such as rifampin (a tuberculosis medicine), can reduce progesterone levels and its effectiveness. Conversely, CYP3A4 enzyme inhibitors like ketoconazole (an antifungal) can increase progesterone levels, potentially leading to adverse side effects. It may also interact with estrogen-containing medicines, carbamazepine, insulin, phenobarbital, venetociax, and edoxaban. Always inform your doctor about all medicines, supplements, and herbal products you are currently taking to avoid undesired interactions.

What precautions should be taken while using ENDOGEST SR 200 MG TABLET?

Avoid taking ENDOGEST SR 200 MG TABLET if you have a known allergy to soy or any of its ingredients. It is generally contraindicated in individuals with breast cancer, unexplained vaginal bleeding, blood clots or clotting disorders, severe liver disease, porphyria, or cerebral hemorrhage. Caution is advised if you have a history of depression, kidney or heart problems, high blood pressure, migraine, gallstones, asthma, fits, systemic lupus erythematosus, or diabetes. Since it can cause dizziness or drowsiness, avoid driving or operating machinery until you know how the medicine affects you. Inform your doctor if you are about to undergo any surgery.

What happens if a dose of ENDOGEST SR 200 MG TABLET is missed?

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to compensate for the missed one.

How should ENDOGEST SR 200 MG TABLET be stored?

ENDOGEST SR 200 MG TABLET should be stored in a cool and dry place, away from direct sunlight. The recommended storage temperature is typically below 30°C (or between 10°C to 25°C). Keep the medicine out of reach and sight of children.