Dilzem 5ml

DILZEM 5ML Injection

DILZEM 5ML is an injectable medication manufactured by Torrent Pharmaceuticals Ltd..

• Name:

  • Brand Name: DILZEM I.V. Injection, DILZEM 5ML Injection
  • Common Name: Diltiazem Hydrochloride Injection

• Composition: Each mL contains 5 mg of Diltiazem Hydrochloride I.P. (Indian Pharmacopoeia). The 5 mL vial contains 25 mg of Diltiazem Hydrochloride, along with excipients like citric acid, sodium citrate dihydrate, sorbitol, and water for injection.

• Uses: DILZEM is a calcium channel blocker used to treat various heart-related conditions. It is primarily prescribed for:

  • Certain forms of arrhythmia, including atrial fibrillation and paroxysmal supraventricular tachycardia (PSVT).
  • Hypertension (high blood pressure).
  • Angina pectoris (chest pain related to heart issues). It works by relaxing blood vessels, decreasing heart rate, reducing the heart's oxygen demand, and improving blood flow.

• Dosage and Administration: DILZEM is administered intravenously under the supervision of a healthcare professional.

  • Initial Bolus Dose: Typically, 0.25 mg/kg actual body weight (e.g., 20 mg for an average patient) administered over 2 minutes. If the response is insufficient, a second bolus dose of 0.35 mg/kg actual body weight (e.g., 25 mg for an average patient) may be given 15 minutes later.
  • Continuous Infusion: Following bolus administration, an initial infusion rate of 10 mg/h is recommended for continued heart rate reduction in atrial fibrillation or flutter, for up to 24 hours. The infusion rate can be increased in 5 mg/h increments up to 15 mg/h if needed.

• Side Effects:

  • Common: Low blood pressure (hypotension), dizziness, headache, nausea, flushing (sense of warmth), edema (swelling), injection site reactions (pain, swelling, redness), constipation, and fatigue.
  • Serious: Signs of allergic reactions (skin rash, swelling of face/lips/mouth/throat, difficulty breathing), severe skin reactions (Stevens-Johnson syndrome), severe stomach pain, yellowing of skin or eyes (liver problems), or a noticeably irregular heartbeat.

• Precautions:

  • Contraindicated in patients with sick sinus syndrome (without a functioning pacemaker), second or third-degree AV block (without a functioning pacemaker), severe hypotension, cardiogenic shock, or known hypersensitivity to the drug.
  • Should not be given concurrently or in close proximity (within a few hours) with intravenous beta-blockers.
  • Caution is advised in patients with liver or kidney problems, heart failure, or Wolff-Parkinson-White (WPW) syndrome.
  • Avoid alcohol consumption as it may worsen side effects.
  • Not recommended for pregnant or breastfeeding women.

• Storage: Store in a refrigerator between 2°C to 8°C (36°F to 46°F). Do not freeze. It may be stored at room temperature for up to 1 month, but should be discarded after that period. Reconstituted material is stable for 24 hours at controlled room temperature or refrigerated.

What is DILZEM 5ML used for?

DILZEM 5ML (Diltiazem) is an injectable medication used for the temporary control of a rapid ventricular rate in conditions like atrial fibrillation or atrial flutter, and for treating paroxysmal supraventricular tachycardia (PSVT). It is also indicated for managing angina (chest pain, including that caused by coronary artery spasm) and hypertension (high blood pressure) in its oral forms, but DILZEM 5ML specifically refers to the intravenous formulation.

How does DILZEM 5ML work?

DILZEM 5ML contains Diltiazem, which is a calcium channel blocker. It works by inhibiting the influx of calcium ions into cardiac muscle and vascular smooth muscle cells during depolarization. This action leads to several effects: it relaxes blood vessels, decreases heart rate by slowing conduction through the sinoatrial and atrioventricular nodes, and reduces the force of heart muscle contraction. These combined effects help to lower blood pressure, reduce the heart's workload, and increase blood and oxygen supply to the heart.

What is the usual dosage for DILZEM 5ML?

For intravenous administration, the initial bolus dose of DILZEM 5ML is typically 0.25 mg per kilogram of actual body weight, administered over 2 minutes. If the response is not adequate, a second bolus dose of 0.35 mg per kilogram can be given 15 minutes later. For ongoing heart rate control, an intravenous infusion can follow, starting at 10 mg per hour, and potentially increased in 5 mg per hour increments up to a maximum of 15 mg per hour. The infusion can be maintained for up to 24 hours.

What are the possible side effects of DILZEM 5ML?

Common side effects can include dizziness, lightheadedness, headache, a slow heartbeat, flushing (feeling hot and redness of the skin), and swelling in the hands, ankles, or feet. Less common side effects may include nausea, vomiting, diarrhea, constipation, nasal congestion, or cough. Serious, but rare, side effects can include very slow heartbeat, symptoms of heart failure (like shortness of breath, sudden weight gain, unusual weakness), signs of liver problems (yellowing skin or eyes, severe stomach pain, dark urine), or severe allergic reactions (rash, hives, swelling of the face, lips, tongue, or throat).

Is DILZEM 5ML safe during pregnancy or breastfeeding?

Pregnancy: Diltiazem is generally not recommended during pregnancy unless the potential benefits significantly outweigh the risks to the fetus. Animal studies have shown potential harm to the embryo and fetus, and there are no adequate, well-controlled studies in pregnant women. Breastfeeding: Diltiazem does pass into breast milk in small amounts. While it's considered unlikely to harm the baby, healthcare providers might suggest an alternative medication or advise monitoring the infant for any unusual sleepiness or changes in feeding patterns.

Can DILZEM 5ML be taken with other medications?

DILZEM 5ML can interact with several other medications. For example, using it with beta-blockers or digitalis can lead to additive effects on cardiac conduction, potentially causing a very slow heart rate or heart block. It can also increase the levels of certain drugs like carbamazepine, cyclosporine, and some statins (increasing the risk of muscle problems). Concomitant use with ivabradine is generally not recommended due to increased heart rate lowering effects. Inform your doctor about all medications, supplements, and herbal products you are taking.

What precautions should be taken while using DILZEM 5ML?

Your doctor will monitor your progress with regular check-ups, which may include blood and urine tests. Use DILZEM 5ML with caution if you have certain heart conditions such as sick sinus syndrome or second/third-degree AV block (unless you have a functioning pacemaker), severe low blood pressure, or liver or kidney disease. Because Diltiazem can cause dizziness or lightheadedness, avoid driving or operating heavy machinery until you know how the medication affects you.

What happens if a dose of DILZEM 5ML is missed?

DILZEM 5ML is typically administered by a healthcare professional in a clinical setting. If you are concerned about a missed dose in an outpatient setting, contact your doctor or pharmacist immediately. For oral formulations, if a dose is missed, it should be taken as soon as it is remembered, unless it is almost time for the next scheduled dose. In that case, the missed dose should be skipped, and the regular dosing schedule resumed. Do not take a double dose to make up for a missed one.

How should DILZEM 5ML be stored?

DILZEM 5ML (Diltiazem hydrochloride injection) should be stored under refrigeration, typically between 2°C and 8°C (36°F to 46°F), and should not be frozen. It may be stored at room temperature for up to one month, after which any remaining portion should be discarded. Reconstituted solutions are generally stable for 24 hours when refrigerated or at controlled room temperature. As DILZEM 5ML comes in single-dose vials, any unused portion should be discarded.