Lupisit M 1000 Mg Tablet (10 Tab)

LUPISIT M 1000 MG TABLET

Lupisit M 1000 mg Tablet is a combination medication manufactured by Lupin Ltd., used for the management of Type 2 Diabetes Mellitus.

• Composition: Each tablet contains Metformin 1000 mg and Sitagliptin 50 mg.
• Uses: This medicine is prescribed to control high blood sugar levels in adults with Type 2 diabetes. It works by increasing insulin release from the pancreas, enhancing the body's sensitivity to insulin, and reducing glucose production by the liver, especially after meals. This helps prevent serious complications of diabetes such as kidney damage, blindness, nerve problems, and cardiovascular issues.
• Dosage and Administration: Lupisit M 1000 mg Tablet should be taken as advised by your doctor, usually once or twice daily with meals to minimize stomach upset. Swallow the tablet whole with a glass of water; do not crush, chew, or break it.
• Side Effects:
  • Common: Hypoglycemia (low blood sugar), dizziness, sweating, hunger pangs, dry mouth, changes in taste, nausea, diarrhea, stomach pain, headache, and upper respiratory tract infections.
  • Serious (rare): Lactic acidosis (a serious condition that requires immediate medical attention), severe allergic reactions (hives, swelling of face/lips/tongue/throat), and pancreatitis (severe stomach pain).
• Precautions: Lupisit M 1000 mg Tablet is not for Type 1 diabetes or diabetic ketoacidosis. It is contraindicated in patients with severe kidney, liver, or heart disease. Inform your doctor if you have a history of pancreatitis or low vitamin B12 levels. Avoid alcohol consumption as it can increase the risk of lactic acidosis. Consult your doctor if you are pregnant, breastfeeding, or planning a pregnancy. Regular monitoring of blood sugar levels and kidney function is recommended during treatment.
• Storage: Store in a cool and dry place, away from direct sunlight, at or below 30°C. Keep out of the sight and reach of children.

What is Lupisit M 1000 mg Tablet used for?

Lupisit M 1000 mg Tablet is primarily used to manage type 2 diabetes mellitus in adults. It is prescribed to help control blood sugar levels, especially when diet and exercise alone, or when either metformin or sitagliptin alone, are not sufficient. This medication also helps lower the risk of various diabetes-related complications such as kidney damage, blindness, nerve problems, heart-related issues, and sexual dysfunction.

How does Lupisit M 1000 mg Tablet work?

Lupisit M 1000 mg Tablet is a combination medicine containing two active ingredients: Metformin (1000 mg) and Sitagliptin (50 mg). Metformin works by reducing the production of glucose in the liver, decreasing the absorption of glucose from the intestines, and enhancing the body's sensitivity to insulin. Sitagliptin works by increasing the release of insulin from the pancreas and reducing the secretion of glucagon (a hormone that raises blood sugar) in a glucose-dependent manner, by inhibiting an enzyme called DPP-4. Together, these actions lead to better control of blood sugar levels.

What is the usual dosage for Lupisit M 1000 mg Tablet?

The daily dosage of Lupisit M 1000 mg Tablet should be taken as advised by your doctor. The dosage can vary depending on individual factors such as your health condition and how you respond to the medicine. It is typically taken once or twice daily with meals to help reduce gastrointestinal side effects. The tablet should be swallowed whole with a glass of water and should not be crushed, chewed, or broken.

What are the possible side effects of Lupisit M 1000 mg Tablet?

Common side effects include diarrhea, nausea, vomiting, abdominal pain, headache, upper respiratory tract infections (like runny nose, sore throat), flatulence, low blood sugar levels (hypoglycemia), metallic taste, constipation, and joint pain. Serious but rare side effects can include lactic acidosis (a buildup of lactic acid in the blood), severe allergic reactions (e.g., hives, swelling of face/lips/tongue/throat causing difficulty breathing), severe blistering of the skin (bullous pemphigoid), and pancreatitis (severe, persistent stomach pain). Long-term use may also lead to Vitamin B12 deficiency.

Is Lupisit M 1000 mg Tablet safe during pregnancy or breastfeeding?

Lupisit M 1000 mg Tablet should be used during pregnancy only if the potential benefits outweigh any risks, and after consulting your doctor. Some sources indicate it may be unsafe or is not recommended, as limited human studies exist and animal studies have shown harmful effects on the developing baby. Similarly, during breastfeeding, it is advisable to consult your doctor, as metformin, one of the components, is known to be excreted into human breast milk. It is generally considered probably unsafe or not recommended for breastfeeding mothers.

Can Lupisit M 1000 mg Tablet be taken with other medications?

Lupisit M 1000 mg Tablet can interact with various medications. Taking it with insulin or other insulin secretagogues (e.g., glimepiride, gliclazide) can increase the risk of low blood sugar. Salicylates (like aspirin) may also enhance its glucose-lowering effect. Other medications that can interact include iodine contrast medium, bronchodilators, corticosteroids, diuretics, NSAIDs, certain antihypertensives, ACE inhibitors, ARBs, Cimetidine, Rifampin, Beta-blockers, and Digoxin. It is crucial to inform your doctor about all prescription and over-the-counter medicines, as well as herbal supplements, you are currently taking to avoid potential interactions.

What precautions should be taken while using Lupisit M 1000 mg Tablet?

It is important to avoid alcohol consumption while taking this medicine, as it can increase the risk of lactic acidosis and hypoglycemia. Caution is advised if you have kidney, liver, or heart disease; the medication is generally not recommended for severe kidney or liver impairment. Your doctor will regularly monitor your blood sugar levels and kidney function. Inform your doctor if you have a history of pancreatitis, severe systemic infections, dehydration, or alcohol dependence. Do not stop taking the medication abruptly without consulting your doctor. Your ability to drive or operate machinery might be affected if your blood sugar levels become too low or too high. This medicine is not recommended for children under 18 years of age.

What happens if a dose of Lupisit M 1000 mg Tablet is missed?

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one. Always consult your doctor before making any changes to your dosage.

How should Lupisit M 1000 mg Tablet be stored?

Lupisit M 1000 mg Tablet should be stored below 30°C or at room temperature. Keep the medicine tightly closed in its original container, as per the label instructions, and out of the sight and reach of children. Unused medicine should be disposed of safely to prevent accidental consumption.