Natrise 15 Mg Tablet (4 Tab)

NATRISE 15 MG TABLET

Natrise 15 mg Tablet, manufactured by SUN PHARMA LABORATORIES LTD., is a prescription medicine primarily used to manage specific fluid and electrolyte imbalances.

• Name

  • Brand Name: Natrise 15 mg Tablet
  • Common Name: Tolvaptan

• Composition

  • Each tablet contains Tolvaptan 15 mg as the active ingredient. Tolvaptan is a selective vasopressin V2-receptor antagonist.

• Uses Natrise 15 mg Tablet is prescribed for:

  • Treating hyponatremia (low sodium levels in the blood) in conditions such as heart failure, liver cirrhosis, and Syndrome of Inappropriate Antidiuretic Hormone (SIADH).
  • Slowing the progression of autosomal dominant polycystic kidney disease (ADPKD) in adults with rapidly progressing disease.

• Dosage and Administration

  • The typical starting dose for hyponatremia is 15 mg once daily.
  • It can be taken with or without food, preferably at the same time each day.
  • Treatment for hyponatremia should generally not exceed 30 days to minimize the risk of liver injury.
  • The first few doses are often initiated in a hospital setting with close monitoring.
  • Patients should drink plenty of water or non-caffeinated drinks to prevent dehydration, typically 5-6 liters per day, as the medicine increases urine production.

• Side Effects Common side effects include:

  • Thirst, dry mouth, increased frequency of urination, excessive urination at night.
  • Headache, dizziness, tiredness, dehydration.
  • Nausea, loose motions (diarrhea), constipation. Serious side effects can include liver injury (dark urine, nausea/vomiting, upper right abdominal discomfort, yellowing of skin/eyes), severe dehydration, and a rapid rise in sodium levels.

• Precautions

  • Pregnancy and Breastfeeding: Not recommended during pregnancy or breastfeeding due to potential harm to the fetus or infant.
  • Liver and Kidney Disease: Use with caution in patients with liver disease and is not recommended in severe liver or kidney impairment (e.g., no urine production).
  • Diabetes: May affect blood sugar levels, requiring monitoring.
  • Alcohol: Avoid alcohol consumption as it may increase the risk of side effects.
  • Drug Interactions: Inform your doctor about other medications, especially ketoconazole, macrolide antibiotics (e.g., erythromycin, azithromycin), diltiazem, and other medicines that increase blood salt levels.

• Storage

  • Store below 30°C.
  • Keep away from heat, direct light, moisture, and out of the reach of children and pets.

What is Natrise 15 mg Tablet used for?

Natrise 15 mg Tablet is primarily used to treat hyponatremia, a condition characterized by abnormally low sodium levels in the blood. This can occur in various conditions such as heart failure, liver disease (cirrhosis), and Syndrome of Inappropriate Antidiuretic Hormone (SIADH). It is also used to manage Autosomal Dominant Polycystic Kidney Disease (ADPKD), a genetic disorder causing numerous kidney cysts.

How does Natrise 15 mg Tablet work?

Natrise 15 mg Tablet contains Tolvaptan, which is a vasopressin receptor antagonist. It works by blocking the action of vasopressin (also known as antidiuretic hormone) in the kidneys. This action increases urine production and reduces the reabsorption of water, leading to a decrease in overall body water content and a subsequent increase in blood sodium levels.

What is the usual dosage for Natrise 15 mg Tablet?

The typical starting dose for Natrise 15 mg Tablet is 15 mg once daily. It can be taken with or without food. The initial doses may be administered under close medical supervision in a hospital setting. Your doctor will determine the correct dose and duration based on your condition and blood sodium levels. It should generally not be taken for more than 30 days to minimize the risk of liver injury.

What are the possible side effects of Natrise 15 mg Tablet?

Common side effects may include headache, dizziness, excessive thirst, dry mouth, increased frequency of urination (including at night), loose motions or diarrhea, tiredness, and dehydration. More serious, though less common, side effects include signs of liver injury such as dark urine, nausea, vomiting, loss of appetite, or yellowing of the skin or eyes (jaundice), which require immediate medical attention.

Is Natrise 15 mg Tablet safe during pregnancy or breastfeeding?

Natrise 15 mg Tablet is generally not recommended for use during pregnancy as its components are known to be harmful to the fetus. Similarly, it is not advised for use while breastfeeding, as the active ingredient may pass into breast milk and potentially harm the baby. Women of childbearing age should use appropriate contraceptive measures to avoid pregnancy during treatment.

Can Natrise 15 mg Tablet be taken with other medications?

Yes, Natrise 15 mg Tablet can interact with several medications. Concomitant use with hypertonic saline solutions may excessively increase blood sodium levels. Taking it with certain diuretics (like thiazide and loop diuretics) can lead to severe dehydration. It may also interact with medications such as ketoconazole, certain macrolide antibiotics (e.g., erythromycin, azithromycin), diltiazem, ACE inhibitors, desmopressin, and phenobarbital. It is important to avoid grapefruit or grapefruit juice while taking this medicine, as it can increase the levels of Natrise in the blood. Always inform your doctor about all other medicines, herbal preparations, and supplements you are currently taking.

What precautions should be taken while using Natrise 15 mg Tablet?

Precautions include careful use in patients with liver disease (requiring liver function monitoring), diabetes, heart disease, or Autosomal Dominant Polycystic Kidney Disease (ADPKD). It is contraindicated if you have anuria (no urine production), severe dehydration, high blood sodium levels, or are unable to sense or respond to thirst. Patients often need to drink 5-6 liters of water or non-caffeinated drinks daily due to increased urination. This medicine is not recommended for children under 18 years of age. Due to potential dizziness and tiredness, caution is advised when driving or operating machinery.

What happens if a dose of Natrise 15 mg Tablet is missed?

If you miss a dose of Natrise 15 mg Tablet, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.

How should Natrise 15 mg Tablet be stored?

Natrise 15 mg Tablet should be stored at room temperature in a cool and dry place. Keep it away from direct heat and light, and always keep it in its original packaging. Ensure it is kept out of the reach and sight of children and pets.