Lupisulin N(nph)40i.u

LUPISULIN N (NPH) 40I.U by LUPIN LTD

Lupisulin N (NPH) 40IU/ml Injection is an intermediate-acting insulin used to manage blood sugar levels in individuals with diabetes mellitus. It is manufactured by Lupin Ltd.

• Name:

  • Common Name: Human Insulin Isophane, NPH Insulin
  • Brand Name: Lupisulin N

• Composition:

  • Each milliliter contains 40 International Units (IU) of Insulin Isophane (Human Insulin).

• Uses:

  • Lupisulin N is prescribed for the treatment of both Type 1 and Type 2 diabetes mellitus in adults and children above two years of age.
  • It effectively regulates blood glucose levels, helps control postprandial (after-meal) blood sugar spikes, and reduces the risk of long-term diabetes complications such such as damage to the retina (retinopathy), kidney (nephropathy), and nerve cells (neuropathy).
  • It works by facilitating glucose uptake by muscle and fat cells and suppressing glucose production in the liver, mimicking the body's natural insulin.

• Dosage and Administration:

  • Lupisulin N should be administered subcutaneously (under the skin) into areas such as the upper thigh, abdomen, upper arm, or buttocks, as advised by a healthcare professional.
  • The exact dosage and duration of treatment are determined by the doctor based on the patient's age, body condition, and severity of diabetes.
  • Injection sites should be rotated regularly to prevent skin damage and changes like lipodystrophy.
  • This medicine should not be administered intravenously (into the vein) and should not be mixed with other insulins before use.

• Side Effects:

  • Common side effects include low blood glucose levels (hypoglycemia), injection site reactions (pain, redness, itching, swelling), weight gain, edema (fluid retention), and changes in skin texture (lipodystrophy or lipoatrophy) at the injection site.
  • Serious side effects can include severe allergic reactions (anaphylaxis) and, rarely, heart failure when used with certain other medications like pioglitazone.

• Precautions:

  • Alcohol: Consumption of alcohol can cause fluctuations in blood glucose levels and should be avoided.
  • Medical Conditions: Patients with kidney, liver, or heart problems should use this medicine with caution, as dose adjustments may be required.
  • Pregnancy and Breastfeeding: It is generally considered safe during pregnancy and breastfeeding, but only under strict medical supervision, as dose adjustments may be necessary.
  • Driving: Ability to concentrate and react may be impaired due to low blood sugar; caution is advised while driving. It is recommended to carry sugar or glucose tablets.
  • Interactions: Inform your doctor about all other medications being taken, especially other antidiabetic agents, corticosteroids, thyroid hormones, and certain pain relievers, as interactions can occur.
  • Do not discontinue therapy without consulting your doctor.

• Storage:

  • Lupisulin N is a cold chain medicine and must be stored in a refrigerator between 2°C and 8°C.
  • Do not freeze the medicine.
  • Once opened, vials or cartridges can be stored at room temperature (below 25°C or 30°C) for up to 28 days (4 weeks).
  • Keep out of the sight and reach of children.

LUPISULIN N(NPH) 40I.U by LUPIN LTD is an intermediate-acting insulin used to manage blood sugar levels in individuals with diabetes. Below are some frequently asked questions about this medicine.

What is LUPISULIN N(NPH) 40I.U used for?

LUPISULIN N(NPH) 40I.U is used to improve blood sugar control in both adults and children with Type 1 and Type 2 Diabetes Mellitus. It helps regulate blood glucose levels and reduces the risk of serious diabetes complications like kidney damage, eye problems, nerve issues, and foot ulcers.

How does LUPISULIN N(NPH) 40I.U work?

This medicine contains Insulin Isophane (NPH), which is an intermediate-acting human insulin. It works by mimicking the body's natural insulin, facilitating the uptake of glucose from the blood into muscle and fat cells for energy, and suppressing the production of glucose by the liver. It typically starts working within 1-2 hours after injection, with peak activity around 7 hours, and an overall duration of action of 18 to 24 hours.

What is the usual dosage and administration?

LUPISULIN N(NPH) 40I.U should be administered exactly as advised by your doctor. It is given as a subcutaneous injection, usually into the upper thigh, abdomen, upper arm, or buttocks. The specific dosage depends on your age, body condition, and the severity of your diabetes. It's crucial to rotate injection sites to prevent skin damage and to never share needles. Do not stop taking it without consulting your doctor.

What are the possible side effects?

The most common side effect is low blood glucose levels (hypoglycemia), which can cause symptoms like tiredness, hunger, headache, nervousness, cold sweats, fast heartbeat, dizziness, and confusion. Other possible side effects include reactions at the injection site (pain, redness, itching, swelling), lipodystrophy (skin thickening or pits at the injection site due to repeated injections), weight gain, and edema (fluid retention causing swelling).

Is LUPISULIN N(NPH) 40I.U safe during pregnancy or breastfeeding?

LUPISULIN N(NPH) 40I.U is generally considered safe to use during pregnancy and breastfeeding if prescribed by a doctor. However, your insulin dose may need adjustment during pregnancy and after delivery, and regular blood sugar monitoring is advised.

Can LUPISULIN N(NPH) 40I.U be taken with other medications?

This medicine can interact with various other medications, including other antidiabetic agents, certain anti-asthmatic drugs, corticosteroids, thyroid hormones, diuretics, pain killers like aspirin, and some antihypertensive agents. Inform your doctor about all medications you are currently taking, as some can affect blood sugar levels or mask the symptoms of hypoglycemia. It should not be mixed with other insulins before use.

What precautions should be taken while using this medicine?

Do not use LUPISULIN N(NPH) 40I.U if you currently have low blood glucose levels (hypoglycemia). Inform your doctor if you have a history of kidney, liver, or heart problems, as dose adjustments may be necessary. Alcohol consumption should be limited, as it can significantly affect blood glucose levels. Drive with caution, especially if you experience symptoms of low blood sugar, which can impair concentration. Always carry a source of sugar (like glucose tablets or juice) to treat mild hypoglycemia.

What happens if a dose is missed?

If you miss a dose, take it as soon as you remember. However, if it's almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to compensate for the missed one, as this can lead to a dangerous drop in blood sugar.

How should LUPISULIN N(NPH) 40I.U be stored?

LUPISULIN N(NPH) 40I.U is a cold chain medicine and must be stored in the refrigerator between 2-8 degrees Celsius. It should not be frozen. Keep it away from direct sunlight and out of the reach of children. Any unused portion should be appropriately discarded according to healthcare provider instructions.