Vildamac M 50/1000 Tablet (15 Tab)

VILDAMAC M 50/1000 TABLET (15 TAB) by MACLEODS PHARMACEUTICALS LTD.

VILDAMAC M 50/1000 Tablet is a medication prescribed for the management of Type 2 Diabetes Mellitus. It is manufactured by Macleods Pharmaceuticals Ltd.

Composition VILDAMAC M 50/1000 Tablet contains two active ingredients:

• Vildagliptin (50 mg)
• Metformin Hydrochloride (1000 mg)

Uses This combination medication is primarily used to control high blood sugar levels in adults with Type 2 Diabetes Mellitus when diet and exercise alone, or treatment with either metformin or vildagliptin individually, are not sufficient. It works by stimulating the pancreas to produce more insulin and less glucagon (due to vildagliptin) and by improving the body's sensitivity to insulin, reducing glucose production by the liver, and decreasing glucose absorption from the intestine (due to metformin). By effectively managing blood sugar, VILDAMAC M 50/1000 Tablet helps reduce the risk of serious diabetes-related complications such as kidney damage, blindness, nerve problems, limb amputations, and cardiovascular events.

Dosage and Administration VILDAMAC M 50/1000 Tablet should be taken as advised by your doctor. It is typically recommended to be taken twice daily. The tablet should be swallowed whole with a glass of water and not crushed, chewed, or broken. While it can be taken with or without food, taking it with meals may help reduce stomach upset. For optimal results, it is recommended to take the medicine at the same time each day. Do not stop taking this medication without consulting your doctor. The dosage will depend on your condition, blood sugar levels, and any other medications you are taking.

Side Effects Common side effects may include:

• Hypoglycemia (low blood glucose levels), characterized by dizziness, sweating, hunger pangs, and dry mouth
• Nausea, vomiting, diarrhea, stomach pain, or upset stomach
• Headache and dizziness
• Fatigue or trembling
• Changes in taste (metallic taste)
• Upper respiratory tract infections or nasopharyngitis

A serious but rare side effect is lactic acidosis, symptoms of which include muscle pain, weakness, difficulty breathing, stomach pain, and a feeling of coldness in the limbs.

Precautions VILDAMAC M 50/1000 Tablet is contraindicated in individuals with known allergies to its components, severe kidney or liver impairment, congestive heart failure, lactic acidosis, or diabetic ketoacidosis.

• Alcohol: Chronic excessive alcohol consumption should be avoided as it increases the risk of lactic acidosis and can affect blood sugar levels.
• Pregnancy and Breastfeeding: This medicine is not recommended during pregnancy or breastfeeding; consult your doctor.
• Kidney and Liver Function: Your doctor may monitor kidney and liver function before and during treatment.
• Vitamin B12 Deficiency: Long-term use may lead to Vitamin B12 deficiency.
• Drug Interactions: Inform your doctor about all other medications you are taking, including cationic medications (e.g., amiloride, digoxin), carbonic anhydrase inhibitors (e.g., topiramate), hyperglycemic medications (e.g., glucocorticoids), ACE-inhibitors, iodinated contrast agents, and CYP3A4 inducers (e.g., rifampicin), as these can interact with VILDAMAC M 50/1000 Tablet.
• This medication is not for Type 1 diabetes or for children under 18 years of age.

Storage Store VILDAMAC M 50/1000 Tablet in a cool and dry place, away from direct sunlight and moisture. It should be kept at a temperature not exceeding 30°C. Keep it out of the sight and reach of children.

VILDAMAC M 50/1000 TABLET is a combination medication used to manage Type 2 Diabetes Mellitus in adults. It contains two active ingredients: Vildagliptin (50 mg) and Metformin (1000 mg).

Here are some frequently asked questions about VILDAMAC M 50/1000 TABLET:

What is VILDAMAC M 50/1000 TABLET used for?

VILDAMAC M 50/1000 TABLET is primarily used to manage high blood sugar levels in adults with Type 2 Diabetes Mellitus. It is prescribed when diet and exercise alone, or treatment with either metformin or vildagliptin alone, are not sufficient to control blood sugar. This medication helps prevent serious complications of diabetes, such as kidney damage, blindness, nerve problems, and cardiovascular events.

How does VILDAMAC M 50/1000 TABLET work?

VILDAMAC M 50/1000 TABLET works through the combined action of its two components:

• Vildagliptin (a DPP-4 inhibitor): It increases the secretion of insulin from the pancreas in a glucose-dependent manner (meaning it acts when blood glucose levels are high). It also reduces the production of glucagon, a hormone that raises blood glucose levels.
• Metformin (a biguanide): It lowers glucose production in the liver, decreases the absorption of glucose from the intestines, and enhances the body's sensitivity to insulin, allowing cells to utilize insulin more effectively. Together, these actions help to regulate blood sugar levels, reducing both fasting and post-meal sugar levels.

What is the usual dosage for VILDAMAC M 50/1000 TABLET?

VILDAMAC M 50/1000 TABLET is typically taken orally, usually twice daily. It is recommended to take it with food to help reduce the chance of an upset stomach and for optimal results, it should be taken at the same time each day. Your doctor will determine the appropriate dose and duration based on your condition, blood sugar levels, and any other medications you are taking. Do not crush, chew, or break the tablet; swallow it whole with water.

What are the possible side effects of VILDAMAC M 50/1000 TABLET?

Common side effects may include low blood glucose (hypoglycemia, especially if taken with other diabetes medicines), headache, dizziness, nausea, vomiting, diarrhea, stomach pain, loss of appetite, metallic taste, joint pain, tiredness, constipation, and swollen hands, ankles, or feet (oedema). Serious but rare side effects include lactic acidosis, a medical emergency caused by increased lactic acid in the blood, which can manifest as vomiting, stomach pain, decreased heartbeat, difficulty breathing, muscle cramps, or severe tiredness. Pancreatitis (inflamed pancreas) is also a rare but serious side effect. If you experience any severe or worsening symptoms, consult your doctor immediately.

Is VILDAMAC M 50/1000 TABLET safe during pregnancy or breastfeeding?

VILDAMAC M 50/1000 TABLET is generally not recommended during pregnancy unless considered necessary by your doctor, as limited human studies exist and animal studies have shown harmful effects on the developing baby. It is also not recommended for breastfeeding women, as its components are known to pass into breast milk. Always consult your doctor before using this medication if you are pregnant, planning to conceive, or breastfeeding.

Can it be taken with other medications?

VILDAMAC M 50/1000 TABLET can interact with various medications. Inform your doctor about all medicines you are taking, including over-the-counter drugs and herbal supplements. Some medications that may interact include:

• Glucocorticoids (e.g., dexamethasone, prednisolone), Beta-2 agonists (e.g., albuterol, terbutaline), and Diuretics (e.g., chlorthalidone, hydrochlorothiazide) can counteract its blood sugar-lowering effect.
• NSAIDs (e.g., ibuprofen, celecoxib), ACE inhibitors (e.g., enalapril, lisinopril), and Angiotensin II receptor antagonists (e.g., losartan, telmisartan) may also interact.
• Cationic medications like amiloride, digoxin, and morphine may interact with metformin.
• Iodinated contrast agents used in imaging may increase the risk of acute kidney failure and lactic acidosis; temporary discontinuation of Vildamac M is advisable during such procedures.
• Alcohol should be avoided as it can lower blood glucose and increase the risk of lactic acidosis.

What precautions should be taken?

• Inform your doctor if you have kidney, liver, or heart problems, or a history of pancreatitis. VILDAMAC M 50/1000 TABLET is contraindicated in severe kidney or liver disease, congestive heart failure, and diabetic ketoacidosis.
• Regular monitoring of blood sugar levels, kidney function, and liver enzymes is essential during treatment.
• Avoid chronic excessive alcohol consumption due to the increased risk of lactic acidosis.
• Do not stop taking the medicine abruptly, even if you feel better, as it can lead to increased blood sugar levels and complications.
• This medication is not suitable for children and adolescents under 18 years of age. Use with caution in elderly patients.

What happens if a dose is missed?

If you miss a dose of VILDAMAC M 50/1000 TABLET, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to compensate for the missed one.

How should it be stored?

Store VILDAMAC M 50/1000 TABLET in a cool and dry place, protected from direct sunlight, moisture, and heat. Keep it out of sight and reach of children and pets. Do not use expired medicines and discard unused medicine properly.