Valkem-od 500 Tablet (10 Tab)

VALKEM-OD 500 TABLET (10 TAB) by ALKEM LABORATORIES LTD

VALKEM-OD 500 Tablet is an extended-release medication primarily used to manage various neurological and psychiatric conditions. It is manufactured by Alkem Laboratories Ltd.

• Name:

  • Brand Name: Valkem-OD 500 Tablet (SR/OD indicates sustained/once daily release)
  • Common Name: Divalproex (a combination of valproic acid and sodium valproate)

• Composition:

  • Active Ingredient: Divalproex 500 mg (equivalent to Valproic acid)
  • Valkem-OD 500 Tablet works by increasing the levels of gamma-aminobutyric acid (GABA) in the brain, a neurotransmitter that helps calm nerve activity and stabilize electrical activity, thereby reducing seizures and manic episodes.

• Uses:

  • Epilepsy/Seizures: Used to manage various types of epilepsy, including complex partial seizures and absence seizures, by controlling abnormal electrical activity in the brain.
  • Bipolar Disorder: Prescribed for treating manic episodes associated with bipolar disorder, helping to stabilize mood swings and reduce agitation.
  • Migraine Prophylaxis: Also used to prevent migraine headaches in adults.

• Dosage and Administration:

  • Valkem-OD 500 Tablet is usually taken once or twice a day, or as prescribed by a doctor.
  • It can be taken with or without food to avoid stomach upset, but consistency in timing is recommended.
  • Tablets should be swallowed whole with a glass of water and should not be crushed or chewed.
  • Do not discontinue the medicine abruptly without consulting a doctor, as this may trigger seizures or worsen the condition.

• Side Effects:

  • Common: Nausea, vomiting, stomach pain, diarrhoea, dizziness, sleepiness, weakness, tiredness, tremors, hair loss, and weight gain.
  • Most side effects are temporary; however, consult a doctor if they persist or worsen.
  • Serious side effects can include liver injury, and mood/behavioral changes, including suicidal thoughts.

• Precautions:

  • Pregnancy and Breastfeeding: Valkem-OD 500 Tablet is contraindicated during pregnancy due to the risk of congenital defects. Caution is advised if breastfeeding, and a doctor should be consulted.
  • Liver/Kidney Conditions: Not recommended for patients with impaired liver function or a history of liver injury, especially children under 2 years of age. Caution is also advised for patients with kidney problems. Liver function tests are often recommended before and during treatment.
  • Alcohol: Avoid alcohol consumption as it can increase the risk of side effects like dizziness and difficulty concentrating.
  • Driving and Operating Machinery: This medicine may cause dizziness or sleepiness; therefore, avoid driving or operating heavy machinery until you know how it affects you.
  • Drug Interactions: Inform your doctor about all other medications, including over-the-counter drugs, as Valkem-OD 500 Tablet can interact with anticoagulants (e.g., warfarin), antidepressants, antipsychotics (e.g., quetiapine), and benzodiazepines (e.g., diazepam), potentially enhancing their effects or increasing side effects.
  • Suicidal Thoughts: Patients should be monitored for new or worsening depression, unusual changes in mood or behavior, or suicidal thoughts.

• Storage:

  • Store at room temperature, ideally below 30°C.
  • Keep away from heat, direct light, excessive moisture, and out of reach of children and pets.
  • Always check the expiry date before use.

VALKEM-OD 500 TABLET (10 TAB) by ALKEM LABORATORIES LTD: Frequently Asked Questions

What is VALKEM-OD 500 TABLET used for?

VALKEM-OD 500 TABLET is primarily used to manage various types of epilepsy and seizures. Additionally, it is prescribed for treating manic episodes associated with bipolar disorder and for the prevention of migraine headaches in adults. It can also function as a mood stabilizer.

How does VALKEM-OD 500 TABLET work?

This medicine contains Valproic acid (Divalproex), which works by reducing excessive and abnormal electrical activity in the brain. It achieves this by increasing the concentration of gamma-aminobutyric acid (GABA), a chemical that helps calm nerve communication and has a soothing effect. It also limits the transmission of nerve pain signals, contributing to its effectiveness in controlling seizures, stabilizing mood, and preventing migraines.

What is the usual dosage for VALKEM-OD 500 TABLET?

The dosage of VALKEM-OD 500 TABLET is determined by your doctor based on your medical condition and response to treatment. It is usually taken once or twice a day. The tablet should be swallowed whole with a glass of water and should not be crushed or chewed. It can be taken with or without food, though taking it with food may help prevent stomach upset. For epilepsy, the dose can be gradually increased under medical supervision until seizures are controlled.

What are the possible side effects of VALKEM-OD 500 TABLET?

Common side effects may include nausea, vomiting, stomach pain, headache, dizziness, drowsiness or sleepiness, tremors, weight gain, and hair loss or thinning. Other reported side effects include weakness, blurred vision, diarrhea, constipation, and unsteadiness. More serious but rare side effects can include skin rash, unusual bruising or bleeding, liver injury, high ammonia levels in the blood, low body temperature, and suicidal thoughts or behaviors. If any side effects persist or worsen, or if you experience severe symptoms, consult your doctor.

Is VALKEM-OD 500 TABLET safe during pregnancy or breastfeeding?

Pregnancy: VALKEM-OD 500 TABLET is generally considered unsafe during pregnancy as there is a definite risk of serious congenital defects to the developing baby. Women of childbearing age should use effective contraception while taking this medicine. If you become pregnant, discontinue the treatment and consult your doctor immediately.

Breastfeeding: Caution is advised if you are breastfeeding, as small quantities of the medicine can pass into breast milk and may affect the infant. Your doctor may recommend monitoring the baby for signs of liver damage. It is essential to discuss breastfeeding with your doctor before taking this medication.

Can VALKEM-OD 500 TABLET be taken with other medications?

VALKEM-OD 500 TABLET can interact with several other medications. It is crucial to inform your doctor about all prescription, over-the-counter, and herbal medicines you are currently taking. Notable interactions include those with blood-thinning medications (like warfarin), some antidepressants, antipsychotics (like quetiapine), benzodiazepines (like diazepam), and certain antibiotics (e.g., carbapenem antibiotics, which may reduce its effectiveness). It may also increase the concentration of lamotrigine, potentially causing serious skin reactions, and can reduce the effectiveness of oral contraceptives.

What precautions should be taken while using VALKEM-OD 500 TABLET?

Do not stop taking VALKEM-OD 500 TABLET suddenly, as this can trigger seizures or worsen your condition; any changes to your dosage should be made under medical supervision. Avoid consuming alcohol, as it can increase dizziness, drowsiness, and the risk of seizures. You should also avoid driving or operating heavy machinery if you experience drowsiness or dizziness. Inform your doctor if you have a history of liver disease, kidney problems, pancreatitis, depression, or suicidal thoughts, as this medicine requires careful consideration in such cases. Liver function tests may be conducted before and during treatment.

What happens if a dose of VALKEM-OD 500 TABLET is missed?

If you miss a dose of VALKEM-OD 500 TABLET, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to compensate for a missed one, as this can lead to an overdose. Missing doses can trigger seizures or cause your condition to worsen, so consistent intake is important.

How should VALKEM-OD 500 TABLET be stored?

VALKEM-OD 500 TABLET should be stored at room temperature, away from excessive heat, direct light, and moisture. Keep this medicine out of the sight and reach of children and pets.