Teneliglip M 500 Mg Tablet (10 Tab)

TENELIGLIP M 500 MG TABLET (10 TAB) by AKUMENTIS HEALTHCARE LTD.

TENELIGLIP M 500 MG TABLET, also known as Teneliglip-M 500 Tablet PR, is an antidiabetic agent prescribed for the management of type 2 diabetes mellitus.

Composition

Each tablet contains a combination of two active ingredients:

• Metformin Hydrochloride: 500 mg
• Teneligliptin Hydrobromide Hydrate: 20 mg

Uses

TENELIGLIP M 500 MG TABLET is primarily used to control high blood sugar levels in adults with type 2 diabetes mellitus. It is prescribed when diet and exercise alone are not sufficient, or when patients do not respond well to Metformin alone. The medication works by:

• Decreasing glucose production in the liver.
• Lowering intestinal glucose uptake.
• Increasing insulin levels in the body and reducing glucagon levels.
• Improving the body's sensitivity to insulin. This action helps prevent serious complications of diabetes such as kidney damage, eye damage, nerve problems, and may reduce the risk of heart attack or stroke.

Dosage and Administration

TENELIGLIP M 500 MG TABLET should be taken as prescribed by a physician. It is typically recommended to take it once daily. The tablet should be swallowed whole with a glass of water and not crushed, chewed, or broken. Taking the medicine with food may help reduce stomach upset. The dosage can vary based on individual factors, including the severity of the condition and patient response to the medication.

Side Effects

Common side effects may include:

• Nausea, vomiting, diarrhea, stomach ache/discomfort
• Headache
• Respiratory infection, sore throat, stuffy nose
• Weight gain, sweating
• Constipation, flatulence, metallic taste in mouth
• Low blood sugar level (hypoglycemia), especially when taken with insulin or sulfonylurea.

Serious side effects, though rare, can include:

• Lactic acidosis, a life-threatening condition requiring immediate medical attention, characterized by symptoms like abdominal pain, muscle cramps, vomiting, severe fatigue, or difficulty breathing.
• Serious allergic reactions (hives, swelling of the face, lips, tongue or throat causing difficulty in breathing or swallowing).
• Severe skin rashes with redness and blistering.
• Vision problems.

Precautions

Before taking TENELIGLIP M 500 MG TABLET, inform your doctor if you have any of the following conditions:

• Kidney, liver, or heart problems (especially heart failure)
• Severe infection, severe trauma, or are due to undergo surgery
• Adrenal insufficiency, bowel obstruction, irregular heartbeat
• Low potassium levels in the blood or severe dehydration due to excessive vomiting or diarrhea.
• Type 1 diabetes, diabetic coma, or severe ketosis.
• Allergies to Metformin, Teneligliptin, or any other components of the tablet.

This medicine is not recommended for use in patients with alcoholism, as it increases the risk of lactic acidosis. Pregnant or breastfeeding women should consult their doctor before taking this medicine, as it may be secreted in breast milk and can harm the newborn. Regular monitoring of blood sugar levels and kidney function is advisable during therapy. Inform your doctor about all other medications you are taking to prevent potential drug interactions with anti-diabetics, iodine contrast medium, bronchodilators, corticosteroids, diuretics, cationic medicines (e.g., amiloride, digoxin, morphine), glucose-altering medicines (e.g., isoniazid), NSAIDs, verapamil, rifampicin, and Olaparib.

Storage

Store TENELIGLIP M 500 MG TABLET in a cool and dry place, protected from direct sunlight, moisture, and heat. It should be kept out of the sight and reach of children and pets. The typical storage temperature should be between 10ºC to 25ºC or below 30ºC.

What is TENELIGLIP M 500 MG TABLET used for?

TENELIGLIP M 500 MG TABLET is an antidiabetic medication used to treat Type 2 Diabetes Mellitus in adults. It is prescribed to help control high blood sugar levels, especially when diet and exercise alone, or metformin monotherapy, are not sufficient to achieve adequate glycemic control. By managing blood sugar effectively, it helps reduce the risk of diabetes-related complications such as kidney damage and vision loss.

How does TENELIGLIP M 500 MG TABLET work?

This medicine is a combination of two active ingredients: Metformin and Teneligliptin. Metformin, a biguanide, works by decreasing glucose production in the liver, reducing glucose absorption from the intestines, and enhancing the body's sensitivity to insulin, which improves glucose uptake and utilization. Teneligliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor that increases the levels of natural substances in the body called incretin hormones (like GLP-1 and GIP). These hormones increase insulin release from the pancreas when blood sugar is high and decrease glucagon levels, thereby reducing glucose production by the liver. Together, these actions lead to better control of both fasting and post-meal blood sugar levels.

What is the usual dosage for TENELIGLIP M 500 MG TABLET?

The dosage of TENELIGLIP M 500 MG TABLET is determined by your doctor, based on your individual needs, condition severity, and response to the medication. It should be taken orally with meals to minimize gastrointestinal side effects. It is crucial to adhere strictly to the prescribed dosage and not to exceed it without consulting your doctor.

What are the possible side effects of TENELIGLIP M 500 MG TABLET?

Common side effects include nausea, vomiting, diarrhea, abdominal pain or discomfort, flatulence (gas), headache, stomach upset, respiratory infection, weight gain, and sweating. Most of these side effects are usually mild and temporary, resolving as your body adjusts to the medication.

More serious, though rare, side effects can occur. These include lactic acidosis (a build-up of lactic acid in the blood), which is a life-threatening condition. Symptoms of lactic acidosis may include abdominal pain, muscle cramps, vomiting, severe fatigue, difficulty breathing, cold hands or feet, dizziness, or an irregular heartbeat. Hypoglycemia (low blood sugar levels) can also occur, especially when this medicine is taken with other antidiabetic medications or insulin. Long-term use of metformin, a component of this medicine, can also lead to Vitamin B12 deficiency. If any side effects persist, worsen, or if you experience symptoms of serious side effects, consult your doctor immediately.

Is TENELIGLIP M 500 MG TABLET safe during pregnancy or breastfeeding?

Pregnancy: TENELIGLIP M 500 MG TABLET is generally not recommended during pregnancy due to potential risks to the fetus. It should only be used if the potential benefit to the mother justifies the potential risk to the fetus, and your doctor may consider alternative treatments like insulin therapy during pregnancy.

Breastfeeding: This medicine is not recommended for use in breastfeeding mothers as it may be secreted into breast milk and potentially cause unwanted effects in the nursing baby. If the medication is absolutely necessary, breastfeeding should be discontinued.

Can TENELIGLIP M 500 MG TABLET be taken with other medications?

TENELIGLIP M 500 MG TABLET can interact with various medications. It's important to inform your doctor about all prescription drugs, over-the-counter medicines, herbal preparations, and supplements you are currently taking. Some medications that may interact include:

• Cationic medicines (e.g., amiloride, digoxin, morphine)
• Diuretics (e.g., furosemide, hydrochlorothiazide)
• Glucose-altering medicines (e.g., isoniazid, corticosteroids like hydrocortisone, prednisone)
• Certain antibiotics (e.g., rifampicin, tetracycline, clarithromycin) and antifungals (e.g., fluconazole)
• Medicines for high blood pressure (e.g., beta-blockers like atenolol, propranolol; ACE inhibitors like enalapril, captopril)
• NSAIDs (non-steroidal anti-inflammatory drugs) like ibuprofen and celecoxib.
• Iodine contrast media (used during X-rays) – use should be discontinued at least 48 hours prior to administration. Your doctor will assess potential interactions and adjust your treatment plan accordingly.

What precautions should be taken while using TENELIGLIP M 500 MG TABLET?

Before taking this medicine, inform your doctor if you have any history of kidney, liver, or heart problems (including heart failure or irregular heartbeat), severe infections, severe trauma, adrenal insufficiency, bowel obstruction, or low potassium levels. Avoid excessive alcohol consumption as it increases the risk of lactic acidosis and low blood sugar. Regular monitoring of blood sugar levels and kidney function is advisable during treatment. If you experience vision problems, exercise caution when driving or operating heavy machinery. Do not stop taking the medication without consulting your doctor, even if your blood sugar levels appear controlled.

What happens if a dose of TENELIGLIP M 500 MG TABLET is missed?

If you miss a dose, take it as soon as you remember. However, if it's almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one.

How should TENELIGLIP M 500 MG TABLET be stored?

Store TENELIGLIP M 500 MG TABLET in a cool and dry place, protected from direct sunlight, moisture, and heat. The typical recommended storage temperature is below 25°C or 30°C. Keep the medicine in its original container, tightly closed, and always out of the sight and reach of children and pets.