Glipy Dm Tab

GLIPY DM TAB

GLIPY DM TAB is a combination medication manufactured by Alembic Pharmaceuticals Ltd, designed to manage blood sugar levels in adults with Type 2 Diabetes Mellitus. It is also known by its brand name, Glipy-DM Tablet, or Glipy-DM Tablet SR (Sustained Release).

---

Composition GLIPY DM TAB contains a triple combination of active ingredients:

• Dapagliflozin (10mg): A sodium-glucose cotransporter-2 (SGLT2) inhibitor that works by increasing the excretion of glucose through urine, thereby lowering blood sugar levels.
• Vildagliptin (100mg): A dipeptidyl peptidase-4 (DPP-4) inhibitor that enhances insulin secretion and reduces glucagon levels, improving blood sugar control.
• Metformin (500mg): A biguanide that decreases glucose production in the liver, reduces sugar absorption from the intestines, and improves the body's sensitivity to insulin.

---

Uses GLIPY DM TAB is primarily used for:

• Management of Type 2 Diabetes Mellitus: It helps control high blood sugar levels in adults when diet and exercise alone are insufficient.
• Improved Glycemic Control: The combination of three antidiabetic agents works synergistically to improve insulin sensitivity, reduce glucose production, and increase glucose excretion.
• Cardiovascular and Renal Protection: It may help reduce the risk of heart failure and kidney complications associated with diabetes.

---

Dosage and Administration GLIPY DM TAB should be taken exactly as prescribed by your doctor. It can be taken with or without food, or as advised by a doctor, preferably at the same time each day to maintain consistent blood sugar levels. The tablet should be swallowed whole with a glass of water and not crushed, chewed, or broken. Do not exceed the recommended dose or stop the medication abruptly without consulting your doctor, as this may lead to uncontrolled blood sugar levels.

---

Side Effects Common side effects may include:

• Vomiting, nausea, abdominal pain.
• Headache.
• Frequent urination, painful urination.
• Genital infections, urinary tract infections.
• Low blood sugar (hypoglycemia).
• Back pain, dizziness, fatigue.

More serious side effects or conditions that require caution include lactic acidosis, especially with hepatic or renal insufficiency. Consult your doctor if side effects persist or worsen.

---

Precautions

• Allergies: Avoid if allergic to dapagliflozin, vildagliptin, metformin, or any other ingredients.
• Pregnancy and Breastfeeding: Limited information is available, and it is generally not recommended during pregnancy or breastfeeding. Consult your doctor.
• Liver and Kidney Problems: Use with caution or avoid if you have liver or severe kidney problems due to an increased risk of lactic acidosis.
• Alcohol Consumption: Limit alcohol intake as it increases the risk of hypoglycemia and lactic acidosis.
• Children: Not recommended for use in children below 18 years of age.
• Other Medical Conditions: Inform your doctor if you have heart problems, uncontrolled diabetes, or severe infections.
• Drug Interactions: Inform your doctor about all current medications, supplements, or herbal products, especially diuretics, insulin, sulfonylureas, or certain antibiotics and heart medications.

---

Storage Store GLIPY DM TAB in a cool and dry place, away from direct sunlight and moisture. Keep it out of the sight and reach of children. It should be stored at temperatures between 10ºC to 25ºC or below 30ºC.

Here are the Frequently Asked Questions (FAQs) about GLIPY DM TAB by ALEMBIC PHARMACEUTICALS LTD:

What is GLIPY DM TAB used for?

GLIPY DM TAB is an antidiabetic medicine primarily used to treat Type 2 Diabetes Mellitus in adults. It helps control high blood sugar levels when diet and exercise alone are insufficient. This medication also contributes to cardiovascular and renal protection, reducing the risk of heart failure and kidney complications associated with diabetes. It can help lower HbA1c levels and maintain stable blood glucose throughout the day.

How does GLIPY DM TAB work?

GLIPY DM TAB is a combination of three active ingredients: Dapagliflozin, Vildagliptin, and Metformin.

• Dapagliflozin (a sodium-glucose cotransporter-2 inhibitor or SGLT2 inhibitor) works by increasing the excretion of excess sugar from the body through urine.
• Vildagliptin (a dipeptidyl peptidase-4 inhibitor or DPP-4 inhibitor) enhances glucose-mediated insulin secretion, which reduces fasting and post-meal blood sugar concentrations by increasing incretin hormones that prompt the pancreas to release more insulin.
• Metformin (a biguanide) helps reduce sugar production by cells in the liver, delays sugar absorption from the intestines, and improves the body's response to insulin.

What is the usual dosage?

The dose of GLIPY DM TAB will be decided by your doctor based on your specific condition. It is crucial to follow your doctor's instructions on the dosage and timing, and you should not change your dosage or stop taking the medication without consulting your doctor. It is often recommended to take it with or after food to help minimize stomach upset.

What are the possible side effects?

Common side effects of GLIPY DM TAB include low blood sugar (hypoglycemia), nausea, vomiting, abdominal pain, headache, frequent urination, genital infections (like vaginal yeast infection), and urinary tract infections. More serious but rare side effects can include lactic acidosis, particularly in patients with hepatic or renal insufficiency. If side effects persist or worsen, consult your doctor.

Is it safe during pregnancy or breastfeeding?

GLIPY DM TAB is generally not recommended during pregnancy, and limited information suggests it may be unsafe due to potential risks to the developing baby; therefore, pregnant women or those planning pregnancy should inform their doctor. Similarly, it is probably unsafe to use during breastfeeding as limited human data suggests the drug may pass into breast milk and harm the baby. Always consult your doctor if you are pregnant or breastfeeding.

Can it be taken with other medications?

You should inform your doctor about all current medications, supplements, or herbal products you are taking to avoid possible interactions. Taking diuretics like furosemide with GLIPY DM TAB can lead to excessive water loss. If you are using other diabetes medications such as insulin or sulfonylureas, your doctor may need to adjust their dosages. Certain medications like rifampicin may reduce the effectiveness of Vildagliptin. Iodinated contrast agents used for X-rays or scans may require temporary discontinuation of GLIPY DM TAB due to the risk of acute kidney failure and lactic acidosis.

What precautions should be taken?

Use GLIPY DM TAB with caution if you have liver or kidney problems, as these conditions can increase the risk of side effects like lactic acidosis. Alcohol consumption should be limited or avoided as it can increase the risk of hypoglycemia and lactic acidosis. Individuals with heart problems or a history of heart attack should also inform their doctor. The medicine is not recommended for children below 18 years of age.

What happens if a dose is missed?

If you forget to take a dose of GLIPY DM TAB, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one, as this can cause your sugar level to fall too rapidly or increase the chance of adverse effects.

How should it be stored?

GLIPY DM TAB should be stored in a cool and dry place, away from direct sunlight and moisture. Keep it out of the sight and reach of children. The medicine should be stored at room temperature, typically between 10ºC to 25ºC or below 30ºC.