Tonact Asp 20/75 Mg (10 Tab) 12% Gst

TONACT ASP 20/75 MG

Tonact-ASP 20/75 MG is a combination medication manufactured by Lupin Ltd., used primarily for cardiovascular health.

• Name:

  • Brand Name: TONACT ASP 20/75 MG
  • Common Name: Atorvastatin and Aspirin Capsules

• Composition:

  • Each capsule contains Atorvastatin 20 mg and Aspirin (Acetylsalicylic acid) 75 mg.
  • Atorvastatin is a lipid-lowering medication (statin) that blocks the enzyme responsible for cholesterol production in the body, reducing "bad" cholesterol (LDL and triglycerides) and increasing "good" cholesterol (HDL).
  • Aspirin is an anti-platelet drug (blood thinner/anticoagulant) that prevents platelets from clumping together, thereby reducing blood clot formation in blood vessels.

• Uses:

  • Prevention of heart attack and stroke.
  • Lowers high cholesterol levels, especially in individuals at high risk of heart disease.
  • Manages mixed dyslipidemia (abnormal levels of blood lipids).
  • Reduces the likelihood of angina (heart-related chest pain).
  • Aids in preventing cardiovascular problems after recent heart bypass surgery (CABG).
  • Offers secondary prevention of cardiovascular diseases for diabetes patients.

• Dosage and Administration:

  • Swallow the capsule whole with a glass of water; do not crush or chew.
  • It can be taken with or without food, preferably at the same time each day.
  • The dosage and duration of treatment are determined by a physician based on the medical condition.
  • Do not stop taking the medicine abruptly, as it may worsen the condition or increase the risk of future cardiovascular events.

• Side Effects:

  • Common Side Effects: Headache, ankle swelling (oedema), dark urine, muscle weakness, slow heart rate, dizziness, nausea, diarrhea, joint pain, body pain, indigestion, heartburn, increased risk of bleeding, nasal passage swelling, bleeding from the nose, insomnia, abnormal liver function tests, urinary tract infection, throat pain.
  • Serious Side Effects: Severe allergic reactions (swelling of lips, face or body, fainting, difficulty swallowing, wheezing), reddening of the skin with high fever, muscle problems like myopathy and rhabdomyolysis, abnormal liver function, increased creatinine levels, Reye's syndrome-like symptoms.

• Precautions:

  • Allergies: Avoid if allergic to atorvastatin, aspirin, or any components.
  • Pregnancy and Breastfeeding: Highly unsafe during pregnancy (pregnancy category X for atorvastatin) and generally not recommended for breastfeeding mothers.
  • Liver Disease: Use with caution or avoid in patients with active liver disease or a history of liver problems due to increased risk of liver damage.
  • Bleeding Disorders: Contraindicated in patients with active bleeding issues (e.g., peptic ulcer, brain hemorrhage) due to the increased risk of bleeding from aspirin.
  • Alcohol: Avoid or limit alcohol consumption as it may increase the risk of gastric bleeding, ulcers, and further liver damage.
  • Drug Interactions: Inform the doctor about all medicines being taken, especially blood thinners (e.g., Warfarin), NSAIDs (e.g., ibuprofen), certain antibiotics (e.g., erythromycin), hepatitis medicines (e.g., Glecaprevir/Pibrentasvir), and medicines for high blood pressure or heart problems (e.g., Amlodipine, Digoxin).
  • Grapefruit: Avoid consuming grapefruit or grapefruit juice as it can increase atorvastatin levels and side effects.
  • Surgery: Inform the doctor or dentist about taking Tonact-ASP before any surgery or dental procedure due to the increased risk of bleeding.
  • Muscle Problems: Monitor for muscle pain, tenderness, or weakness, especially with fever or dark urine.
  • Children: Safety and effectiveness have not been established; avoid use in pediatric patients.

• Storage:

  • Store in a cool and dry place, away from direct sunlight.
  • Keep out of sight and reach of children.
  • Store at 10ºC to 25ºC or below 30ºC.

TONACT ASP 20/75 MG is a combination medication containing Atorvastatin (20 mg) and Aspirin (75 mg). It is primarily used to manage high cholesterol levels and prevent serious cardiovascular events.

What is TONACT ASP 20/75 MG used for?

TONACT ASP 20/75 MG is used to prevent heart attack and stroke. It also helps to lower elevated levels of "bad" cholesterol (low-density lipoproteins or LDL) and triglycerides, while increasing "good" cholesterol (high-density lipoproteins or HDL) in individuals at high risk of heart disease. Additionally, it is prescribed for patients who have undergone recent heart bypass surgery (CABG) to help control cholesterol and prevent blood clots, and to reduce the likelihood of angina (chest pain).

How does TONACT ASP 20/75 MG work?

TONACT ASP 20/75 MG works through its two active ingredients: Atorvastatin and Aspirin. Atorvastatin is a statin that blocks an enzyme in the body (HMG-CoA reductase) that is essential for making cholesterol, thereby reducing bad cholesterol and triglycerides and increasing good cholesterol. Aspirin is an anti-platelet agent that prevents platelets from clumping together to form blood clots in the blood vessels, ensuring smooth blood flow and reducing the risk of heart attacks and strokes.

What is the usual dosage of TONACT ASP 20/75 MG?

The dosage of TONACT ASP 20/75 MG should be taken exactly as prescribed by your physician. It should be swallowed whole with a glass of water, and not crushed or chewed. Taking it at the same time each day can help with remembering the dose. This medicine is often recommended to be taken with food to prevent stomach upset.

What are the possible side effects of TONACT ASP 20/75 MG?

Common side effects of TONACT ASP 20/75 MG can include headache, nausea, indigestion, diarrhea, constipation, stomach pain, dizziness, muscle pain, joint pain, and ankle swelling (oedema). More serious, but less common, side effects may include severe allergic reactions, liver damage, muscle problems (myopathy and rhabdomyolysis), dark urine, and increased bleeding risk. If side effects are persistent or severe, it is important to consult your doctor.

Is TONACT ASP 20/75 MG safe during pregnancy or breastfeeding?

TONACT ASP 20/75 MG is considered unsafe during pregnancy, as Atorvastatin is a pregnancy category X medicine and studies have shown significant harmful effects to the developing baby. Women of childbearing age should use effective contraception while taking this medicine. It is also unsafe during breastfeeding, as the medicine can pass into breast milk and may harm the baby. Your doctor should be informed if you are pregnant, planning a pregnancy, or breastfeeding.

Can TONACT ASP 20/75 MG be taken with other medications?

TONACT ASP 20/75 MG can interact with several other medications. Concomitant use with blood thinners like warfarin or heparin can increase the risk of bleeding. Taking it with NSAIDs (e.g., ibuprofen, naproxen, ketorolac) may increase the risk of stomach ulcers or bleeding. Certain antibiotics (like erythromycin), antifungals (like itraconazole, posaconazole), and antiviral medicines (like ritonavir, Glecaprevir/Pibrentasvir) can increase the levels of atorvastatin, leading to a higher risk of side effects. It's crucial to inform your doctor about all medications you are taking to avoid potential interactions.

What precautions should be taken?

Avoid consuming alcohol with TONACT ASP 20/75 MG as it can increase the risk of gastric bleeding, ulcers, and liver damage. Inform your doctor if you have active liver disease, bleeding disorders, a history of stomach ulcers, gout, or kidney problems. Close monitoring for muscle pain, tenderness, or weakness is necessary, especially during the initial months of treatment, as atorvastatin can cause muscle problems. Always inform your doctor that you are taking this medicine before any surgery or dental procedures, as it can increase bleeding risk.

What happens if a dose of TONACT ASP 20/75 MG is missed?

If you miss a dose of TONACT ASP 20/75 MG, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to compensate for the missed one.

How should TONACT ASP 20/75 MG be stored?

TONACT ASP 20/75 MG should be stored in a cool, dry place, away from direct sunlight and moisture. The temperature should ideally be between 10ºC to 25ºC or below 30ºC. Keep it out of the sight and reach of children. Always check the expiry date before using the medicine.