Repace 50 Mg Tablet (10 Tab)

REPACE 50 MG TABLET is a medication manufactured by SUN PHARMA LABORATORIES LTD., primarily used for managing hypertension and various cardiovascular conditions.

Name

• Brand Name: REPACE 50 MG TABLET
• Common Name: Losartan Potassium

Composition

• Active Ingredient: Losartan 50 mg

Uses

REPACE 50 MG TABLET is an angiotensin II receptor blocker (ARB) used to:

• Treat high blood pressure (hypertension) in adults and children above six years of age.
• Manage heart failure in adults.
• Protect kidneys in diabetic patients with type 2 diabetes and proteinuria (diabetic nephropathy).
• Reduce the risk of stroke in patients with high blood pressure and left ventricular hypertrophy (enlargement of the heart's left side).

Dosage and Administration

The usual starting and maintenance dose for most patients is 50 mg once daily. It should be taken orally with a glass of water, with or without food, at the same time each day. For individuals with intravascular volume depletion (e.g., those on high-dose diuretics), a lower starting dose of 25 mg once daily may be considered. The total daily dose can range from 25 mg to 100 mg, administered once or twice daily. Do not crush, chew, or break the tablet.

Side Effects

Common Side Effects:

• Dizziness
• Tiredness/Weakness
• Low blood pressure (hypotension)
• Diarrhea
• Nasal congestion or stuffy nose
• Increased blood urea levels
• Increased potassium levels in blood (hyperkalemia)
• Low blood sugar (hypoglycemia)

Serious Side Effects:

• Severe allergic reactions (rash, itching, swelling of face, lips, mouth, throat, difficulty breathing)
• Significant changes in kidney function, including renal failure.

Precautions

• Pregnancy: REPACE 50 MG TABLET is contraindicated during the second and third trimesters of pregnancy as it can cause serious harm or death to the unborn baby.
• Breastfeeding: Consult a doctor before use as it is unknown if losartan is excreted in human milk.
• Alcohol: Avoid or limit alcohol consumption as it may increase the risk of low blood pressure and dizziness.
• Liver/Kidney Problems: Use with caution in patients with kidney or liver impairment, and regular monitoring of kidney function and potassium levels is recommended.
• Drug Interactions: Inform your doctor about all medications, especially diuretics, potassium-sparing diuretics, potassium supplements, NSAIDs (e.g., ibuprofen, indomethacin), ACE inhibitors, and aliskiren, as interactions can occur.
• Driving/Operating Machinery: May cause dizziness; exercise caution when driving or operating machinery.

Storage

Store in a cool and dry place, below 30°C. Protect from direct sunlight and moisture, and keep it out of sight and reach of children.

REPACE 50 MG TABLET, manufactured by SUN PHARMA LABORATORIES LTD., contains Losartan as its active ingredient. It is primarily used to treat high blood pressure and other related cardiovascular conditions.

What is REPACE 50 MG Tablet used for?

REPACE 50 MG Tablet is primarily used to treat high blood pressure (hypertension) in adults and children over six years of age. It is also prescribed to manage heart failure in adults, prevent future heart attacks and strokes, and protect kidney function in patients with type 2 diabetes and high blood pressure (diabetic nephropathy).

How does REPACE 50 MG Tablet work?

REPACE 50 MG Tablet contains Losartan, which belongs to a class of medicines called angiotensin II receptor blockers (ARBs). It works by blocking the action of a hormone called angiotensin II, which normally causes blood vessels to narrow and increases blood pressure. By blocking these receptors, Losartan helps relax and widen the blood vessels, reducing resistance to blood flow and lowering blood pressure. This allows the heart to pump blood more efficiently.

What is the usual dosage?

For most adult patients, the usual starting and maintenance dose of REPACE 50 MG Tablet is 50 mg once daily. Your doctor may adjust the dose based on your response, with a total daily dose ranging from 25 mg to 100 mg, which can be taken once or twice daily. For individuals with depleted intravascular volume (e.g., those on high-dose diuretics), a lower starting dose of 25 mg once daily might be considered. It is recommended to take the tablet at the same time each day, with or without food.

What are the possible side effects?

Common side effects of REPACE 50 MG Tablet are generally mild and temporary, including dizziness, tiredness, low blood pressure, weakness, nasal congestion, back pain, and diarrhea. Some individuals may experience an increase in potassium levels in the blood (hyperkalemia) or decreased blood sugar (hypoglycemia). Serious but less common side effects can include severe allergic reactions (swelling of the face, lips, throat), significant changes in kidney function, or problems with heart rhythms. If you experience persistent or severe side effects, consult your doctor.

Is it safe during pregnancy or breastfeeding?

REPACE 50 MG Tablet is considered unsafe and is generally not recommended during pregnancy, especially in the second and third trimesters, as it can cause serious harm or even death to the unborn baby. If you become pregnant while taking this medicine, stop it immediately and contact your doctor. It is also not recommended during breastfeeding, as it is unknown if the medicine passes into human milk and could be unsafe for the baby. A doctor should be consulted to assess the benefits and risks or to find a safer alternative.

Can it be taken with other medications?

REPACE 50 MG Tablet can interact with other medications. Inform your doctor about all prescription and over-the-counter medicines, vitamins, and herbal supplements you are taking. Key interactions to be aware of include:

• Potassium-sparing diuretics (e.g., spironolactone, amiloride, triamterene) and potassium supplements: These can increase the risk of high potassium levels in the blood.
• NSAIDs (Nonsteroidal Anti-inflammatory Drugs) like ibuprofen or naproxen: Concurrent use may reduce the antihypertensive effect and increase the risk of kidney problems.
• Other antihypertensive agents (e.g., ACE inhibitors like enalapril, ramipril, or aliskiren): Combining these can increase the risk of low blood pressure, kidney impairment, and hyperkalemia.
• Lithium: Losartan may increase lithium levels, leading to toxicity.
• Fluconazole and Rifampin: These can affect the levels of Losartan's active metabolite in the blood.

What precautions should be taken?

• Kidney and Liver Conditions: Inform your doctor if you have kidney or liver problems, as dose adjustments may be necessary, and the medicine should be used with caution.
• Alcohol Consumption: It is advisable to avoid or limit alcohol, as it can further lower blood pressure and increase the risk of side effects like dizziness.
• Dizziness: REPACE 50 MG Tablet may cause dizziness. Avoid driving or operating heavy machinery until you know how the medicine affects you.
• Monitoring: Regular monitoring of kidney function, blood pressure, and potassium levels is important while taking this medication.
• Allergies: Do not take this medicine if you are allergic to Losartan or any other ingredients in the tablet.
• Sudden Discontinuation: Do not stop taking REPACE 50 MG Tablet suddenly without consulting your doctor, as it can lead to a rise in blood pressure and worsen your condition.

What happens if a dose is missed?

If you miss a dose of REPACE 50 MG Tablet, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one.

How should it be stored?

REPACE 50 MG Tablet should be stored in a cool and dry place, typically below 30°C. Keep it in its original packaging to protect it from sunlight and moisture. Always keep it out of sight and reach of children.