Glucoryl Mp 1 Tab

GLUCORYL MP 1 TAB

Glucoryl MP 1 Tablet, manufactured by ALKEM LABORATORIES LTD., is an antidiabetic medication used for the management of Type 2 Diabetes Mellitus. It is prescribed when diet and exercise alone, or treatment with a single antidiabetic agent, are insufficient to control blood sugar levels. This medicine helps to control high blood sugar, thereby lowering the risk of diabetes-related complications such as nerve problems, kidney problems, eye problems, and cardiovascular disease.

Composition Glucoryl MP 1 Tablet contains a combination of three active ingredients:

• Glimepiride (1 mg): A sulfonylurea that stimulates the pancreas to release more insulin.
• Metformin (500 mg): A biguanide that reduces glucose production in the liver, delays sugar absorption from the intestines, and increases the body's sensitivity to insulin.
• Pioglitazone (15 mg): A thiazolidinedione that increases the sensitivity of liver, muscle, and fat cells to insulin, enabling them to remove glucose more effectively from the blood.

Uses Glucoryl MP 1 Tablet is primarily used for the treatment of Type 2 Diabetes Mellitus in adults. It works by improving insulin sensitivity, reducing hepatic glucose production, enhancing peripheral glucose uptake and utilization, and delaying intestinal glucose absorption.

Dosage and Administration The tablet should be taken orally, preferably with meals, or as advised by the physician. It should be swallowed whole with water and not crushed or chewed. The dosage and duration of therapy depend on the patient's age, body weight, and disease condition, and should be strictly followed as prescribed by a doctor. Doubling the dose should be avoided.

Side Effects Common side effects may include:

• Hypoglycemia (low blood sugar levels), which can cause headache, nausea, and dizziness.
• Gastrointestinal issues such as stomach pain, nausea, diarrhea, vomiting, and loss of appetite.
• Metallic taste.
• Headache.
• Weight gain.
• Muscle pain, joint pain, or back pain.
• Edema (swelling due to fluid build-up).
• Respiratory tract infections.

Serious side effects that require immediate medical attention include signs of lactic acidosis (e.g., cold hands or feet, unusual muscle pain, trouble breathing, dizziness, irregular heartbeat) or symptoms of heart failure (e.g., unusual shortness of breath, rapid weight increase, swelling in ankles or legs).

Precautions

• Allergies: Do not take if allergic to glimepiride, metformin, pioglitazone, or any other ingredients.
• Pregnancy and Breastfeeding: Not recommended during pregnancy as it may harm the unborn baby, and breastfeeding should be avoided as it may be excreted in human milk.
• Pre-existing Conditions: Inform your doctor if you have liver, kidney, or heart problems (especially severe heart failure), bladder cancer, or metabolic acidosis (like lactic acidosis, diabetic ketoacidosis).
• Alcohol Consumption: Avoid alcohol as it may increase the risk of lactic acidosis and low blood sugar.
• Driving: May decrease alertness; drive only if you are alert after taking the medicine.
• Drug Interactions: Inform your doctor about all medicines, supplements, or herbals you are taking to avoid potential interactions. Interactions can occur with other antidiabetic agents, non-steroidal anti-inflammatory agents, antibiotics, antifungals, anticoagulants, and certain heart and blood pressure medications.
• Children and Elderly: Not recommended for children. Use with caution in elderly patients.
• Overdose: Exceeding the recommended dose can lead to hypoglycemia, lactic acidosis, and pancreatitis. Seek immediate medical attention in case of suspected overdose.

Storage Store in a cool and dry place, away from direct sunlight. Keep it in its original container, tightly closed, and out of reach and sight of children. Store below 30°C.

GLUCORYL MP 1 TAB is a medication prescribed for the management of type 2 diabetes mellitus. It contains a combination of three active ingredients: Glimepiride, Metformin, and Pioglitazone, which work together to help control blood sugar levels when diet, exercise, and single-agent treatments are not sufficient.

What is GLUCORYL MP 1 TAB used for?

GLUCORYL MP 1 TAB is primarily used to treat type 2 diabetes mellitus in adults. It helps control high blood sugar levels, especially when diet and exercise alone, or with a single antidiabetic agent, are not enough. This medication aids in preventing complications associated with diabetes, such as kidney damage, nerve problems, eye problems, and cardiovascular disease.

How does GLUCORYL MP 1 TAB work?

GLUCORYL MP 1 TAB works through the combined action of its three active ingredients:

• Glimepiride: This acts on the pancreas to increase the release of insulin, a hormone that helps move sugar from the blood into cells.
• Metformin: This reduces the production of glucose by the liver and decreases the absorption of sugar from the intestines. It also improves the body's sensitivity to insulin.
• Pioglitazone: This increases the sensitivity of liver, muscle, and fat cells to insulin, helping them absorb and utilize glucose more effectively from the blood.

What is the usual dosage for GLUCORYL MP 1 TAB?

GLUCORYL MP 1 TAB should be taken exactly as directed by your doctor. It is typically taken once daily with a meal to minimize gastrointestinal side effects. Your doctor will determine the correct dose and duration of treatment based on your age, body weight, and the severity of your condition. It is crucial not to exceed the recommended dose.

What are the possible side effects of GLUCORYL MP 1 TAB?

Common side effects include low blood sugar (hypoglycemia), nausea, vomiting, diarrhea, abdominal pain, headache, a metallic taste in the mouth, muscle pain, and weight gain. Less common side effects can include eye disorders, fractures, upper respiratory tract infections, and fluid retention. If side effects persist or worsen, consult your doctor.

Is GLUCORYL MP 1 TAB safe during pregnancy or breastfeeding?

GLUCORYL MP 1 TAB is generally not recommended during pregnancy as it may harm the unborn baby. Similarly, it should not be used while breastfeeding, as it is not known if it passes into human milk and could harm the baby. Always inform your doctor if you are pregnant, planning a pregnancy, or breastfeeding.

Can GLUCORYL MP 1 TAB be taken with other medications?

GLUCORYL MP 1 TAB can interact with other medications, potentially affecting its effectiveness or increasing the risk of side effects. It is important to inform your doctor about all medicines, supplements, or herbal products you are currently taking, especially other antidiabetic agents (like insulin), blood pressure medications, antibiotics, painkillers, blood thinners (like warfarin), and certain heart medications. Combining it with insulin or other antidiabetic agents can increase the risk of hypoglycemia.

What precautions should be taken when using GLUCORYL MP 1 TAB?

Inform your doctor about any pre-existing medical conditions, particularly kidney, liver, or heart problems, class III or IV heart failure, or a history of bladder cancer. Regular monitoring of blood sugar levels is essential during treatment. Avoid excessive alcohol consumption, as it can increase the risk of low blood sugar and lactic acidosis. If you experience symptoms of low blood sugar, consume a sugary snack or drink.

What happens if a dose of GLUCORYL MP 1 TAB is missed?

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to compensate for the missed one, as this can lead to low blood sugar levels.

How should GLUCORYL MP 1 TAB be stored?

Store GLUCORYL MP 1 TAB at room temperature, below 30°C, in a cool, dry place. Protect it from light and moisture. Keep the medication out of the reach of children and pets.