Gluxit Trio 10/100/500 Mg Tablet (15 Tab)

GLUXIT TRIO 10/100/500 MG TABLET (15 TAB) by ERIS LIFESCIENCES LIMITED

Name

Brand Name: GLUXIT TRIO 10/100/500 MG TABLET

Composition

GLUXIT TRIO 10/100/500 MG TABLET contains a combination of three active ingredients:

• Dapagliflozin: 10 mg
• Sitagliptin: 100 mg
• Metformin: 500 mg

Uses

GLUXIT TRIO 10/100/500 MG TABLET is prescribed for the management of Type 2 Diabetes Mellitus in adults. It is used to improve blood sugar control, especially when diet and exercise alone, or therapy with metformin alone, or dual therapy with metformin and either dapagliflozin or sitagliptin, is inadequate. This medication works through a multi-pronged approach: Dapagliflozin reduces glucose reabsorption in the kidneys, leading to increased glucose excretion in urine; Sitagliptin enhances insulin release and decreases glucagon levels; and Metformin decreases glucose production in the liver and improves insulin sensitivity. It can also aid in weight management and help reduce cardiovascular risk.

Dosage and Administration

This medicine should be taken as directed by a physician. Typically, it is an oral medication that should be swallowed whole with a glass of water, without crushing or chewing. It can be taken with or without food, but taking it at the same time each day is recommended for optimal benefits. Do not exceed the prescribed dose or stop the medication abruptly without consulting your doctor.

Side Effects

Common Side Effects:

• Nausea
• Diarrhea
• Headache
• Genital fungal infections
• Urinary tract infections (UTIs)
• Common cold/Nasopharyngitis
• Back pain
• Cough
• Abdominal pain or discomfort

Serious Side Effects (consult a doctor immediately if experienced):

• Lactic acidosis (symptoms include rapid breathing, stomach pain, muscle cramps, weakness)
• Hypoglycemia (low blood sugar), especially when used with other anti-diabetic medications or insulin
• Ketoacidosis (nausea, vomiting, confusion, fruity breath)
• Allergic reactions (rash, itching, swelling of face, tongue, or lips)
• Pancreatitis (severe stomach pain, nausea)
• Liver problems (yellowing of skin/eyes, dark urine)
• Fournier's gangrene (pain, tenderness, redness, or swelling in the genital or perineal area with fever or general discomfort)

Precautions

• Kidney/Liver Impairment: Not recommended for severe kidney impairment, end-stage renal disease (ESRD), or those on dialysis. Use with caution in patients with liver issues due to the risk of lactic acidosis.
• Pregnancy & Breastfeeding: Consult a doctor before use if pregnant or breastfeeding. Breastfeeding is generally not recommended.
• Alcohol: Limit alcohol consumption as it can increase the risk of lactic acidosis.
• Drug Interactions: Inform your doctor about all other medications, supplements, and herbal products, especially diuretics, insulin, insulin secretagogues (e.g., sulfonylureas), ketoconazole, clarithromycin, ritonavir, digoxin, beta-blockers, cimetidine, or birth control pills, as interactions can occur.
• Other Conditions: Exercise caution in patients with cardiac insufficiency, coronary artery disease, hypertension, preexisting arrhythmias, gastrointestinal disorders, severe respiratory disease, epilepsy, and hyperthyroidism.
• Dehydration: Drink plenty of fluids to prevent dehydration.
• Children: Not recommended for use in children below 18 years of age.

Storage

Store GLUXIT TRIO 10/100/500 MG TABLET in a cool and dry place, below 30°C. Keep the medicine away from moisture and direct sunlight. Always place the medicine out of children's reach. Use before its expiry date.

Gluxit Trio 10/100/500 MG Tablet is a combination medicine used for the management of type 2 diabetes mellitus in adults. It contains Dapagliflozin (10 mg), Sitagliptin (100 mg), and Metformin (500 mg) as active ingredients. This medication helps to improve blood sugar control when diet and exercise alone, or dual therapy with metformin and either dapagliflozin or sitagliptin, are insufficient. Additionally, it may aid in weight management and help reduce cardiovascular risk in some individuals.

What is Gluxit Trio 10/100/500 MG Tablet used for?

Gluxit Trio 10/100/500 MG Tablet is prescribed for adults with type 2 diabetes mellitus to help control high blood sugar levels. It is used in conjunction with a healthy diet and regular exercise. The medicine works to improve glycemic control, can assist with weight management, and may lower the risk of cardiovascular disease in certain patients with type 2 diabetes.

How does Gluxit Trio 10/100/500 MG Tablet work?

Gluxit Trio 10/100/500 MG Tablet combines three antidiabetic medicines that work through different mechanisms:

• Dapagliflozin (10 mg): This is a sodium-glucose co-transporter 2 (SGLT2) inhibitor. It works by reducing the reabsorption of glucose in the kidneys, leading to more glucose being excreted through urine and thus lowering blood glucose levels. It can also help reduce body weight and blood pressure.
• Sitagliptin (100 mg): This is a dipeptidyl peptidase-4 (DPP-4) inhibitor. It helps control blood sugar by increasing the levels of natural substances (incretins) in the body that stimulate the pancreas to release more insulin when blood sugar is high and signal the liver to decrease glucose production.
• Metformin (500 mg): This is a biguanide that primarily works by decreasing the production of glucose in the liver and reducing glucose absorption from the intestines. It also improves the body's sensitivity to insulin, helping cells utilize glucose more effectively.

This triple action provides comprehensive control of blood sugar levels.

What is the usual dosage of Gluxit Trio 10/100/500 MG Tablet?

The dosage of Gluxit Trio 10/100/500 MG Tablet is determined by your doctor based on your health condition and response to the medicine. It should be taken exactly as prescribed. The tablet should be swallowed whole with a glass of water and not crushed or chewed. It can be taken with or without food, but it is often recommended to take it with meals to minimize gastrointestinal side effects and at the same time each day for optimal benefits. Do not exceed the prescribed dose or stop taking the medicine without consulting your doctor.

What are the possible side effects of Gluxit Trio 10/100/500 MG Tablet?

Common side effects of Gluxit Trio 10/100/500 MG Tablet can include genital infections (such as fungal infections), urinary tract infections, common cold, diarrhea, headache, nausea, influenza, back pain, and cough. Some individuals may also experience hypoglycemia (low blood glucose level), especially when taken with other antidiabetic medicines or alcohol, or if meals are skipped.

Serious but rare side effects that require immediate medical attention include signs of lactic acidosis (weakness, difficulty breathing, stomach pain), ketoacidosis (nausea, vomiting, confusion, fruity breath), severe or persistent genital/urinary infections, pancreatitis (severe stomach pain, nausea), or allergic reactions (rash, swelling, breathing problems).

Is Gluxit Trio 10/100/500 MG Tablet safe during pregnancy or breastfeeding?

Gluxit Trio 10/100/500 MG Tablet is generally not recommended during pregnancy or breastfeeding. Some ingredients may potentially harm the baby or affect milk production. It is crucial to inform your doctor if you are pregnant, planning a pregnancy, or breastfeeding, as they can discuss safer alternatives.

Can Gluxit Trio 10/100/500 MG Tablet be taken with other medications?

Gluxit Trio 10/100/500 MG Tablet can interact with certain other medications. It is important to inform your doctor about all prescription, non-prescription, herbal supplements, and over-the-counter medicines you are currently taking.

Potential interactions include:

• Diuretics (water pills): Medicines like furosemide or hydrochlorothiazide can increase the risk of volume depletion or lactic acidosis when taken with Gluxit Trio.
• Insulin and insulin secretagogues: When taken with medicines like insulin or glimepiride, there's an increased risk of hypoglycemia (low blood sugar), which may necessitate a lower dose of these medications.
• Corticosteroids: Medicines like dexamethasone used for pain and inflammatory conditions may interact.
• Certain antibiotics and antifungals: Medicines like clarithromycin, ketoconazole, and itraconazole may interact.
• Ritonavir: Used for viral infections, may interact.
• Carbonic Anhydrase Inhibitors: Such as acetazolamide, can increase the risk of lactic acidosis.

Your doctor will advise on appropriate adjustments or alternatives to avoid unwanted interactions.

What precautions should be taken?

Several precautions should be considered while taking Gluxit Trio 10/100/500 MG Tablet:

• Kidney and Liver Conditions: This medication is not recommended for use in patients with severe kidney disease or liver disease due to an increased risk of lactic acidosis from metformin. Use with caution in mild to moderate kidney issues with regular monitoring.
• Alcohol Consumption: Avoid excessive alcohol intake as it can increase the risk of lactic acidosis, a serious side effect of metformin.
• Dehydration: Drink plenty of fluids to prevent dehydration, especially in hot weather or when sick, as dapagliflozin can increase fluid loss through urine.
• Hypersensitivity: Do not take this medicine if you have a known allergy to dapagliflozin, sitagliptin, metformin, or any other components of the tablet.
• Other Conditions: It is not suitable for individuals with type 1 diabetes, diabetic ketoacidosis, metabolic acidosis, respiratory failure, heart failure, or a recent myocardial infarction.
• Surgical Procedures: Inform your doctor if you are undergoing surgery or a diagnostic procedure requiring an iodine-containing contrast agent, as metformin may need to be temporarily stopped.
• Elderly Patients: Dose adjustments and regular monitoring of kidney function may be required in elderly patients.
• Children: The safety and effectiveness in children under 18 have not been established.

Regular monitoring of blood sugar levels and kidney function is essential during treatment.

What happens if a dose is missed?

If you miss a dose of Gluxit Trio 10/100/500 MG Tablet, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed one and continue with your regular dosing schedule. Do not take a double dose to compensate for the missed one.

How should it be stored?

Gluxit Trio 10/100/500 MG Tablet should be stored at a consistent temperature below 30°C. Keep the medicine away from moisture and direct sunlight. Always store it out of the reach and sight of children and pets. Use the medicine before its expiry date.