Dapalex M 10 Mg/500 Mg Tablet (15 Tab)

DAPALEX M 10 MG/500 MG TABLET

DAPALEX M 10 MG/500 MG TABLET is an oral anti-diabetic medication manufactured by Ajanta Pharma Limited, prescribed for the management of Type 2 Diabetes Mellitus.

• Name

  • Brand Name: Dapalex M 10/500 Tablet
  • Common Name: Dapagliflozin and Metformin Tablets

• Composition Each tablet contains:

  • Dapagliflozin: 10 mg
  • Metformin: 500 mg

• Uses DAPALEX M 10/500 MG TABLET is primarily used for:

  • Treatment of Type 2 Diabetes Mellitus in adults to control high blood sugar levels, especially when diet and exercise alone are insufficient.
  • Improving glycemic control by enhancing insulin sensitivity, decreasing glucose production in the liver, and promoting glucose excretion through urine.
  • Reducing the risk of serious complications associated with diabetes, such as kidney damage, blindness, nerve damage, and heart disease or hospitalization for heart failure in adults with Type 2 diabetes and established cardiovascular disease or multiple cardiovascular risk factors.

• Dosage and Administration

  • Take DAPALEX M 10/500 MG TABLET orally as prescribed by your doctor, usually once daily in the morning, with or without food.
  • Swallow the tablet whole with a glass of water; do not crush, chew, or break it.
  • For optimal results and to aid memory, take it at the same time each day.
  • This medication is part of a comprehensive treatment plan that should include a healthy diet, regular exercise, and weight management.

• Side Effects Common side effects may include:

  • Nausea, vomiting, diarrhea, stomach ache, loss of appetite.
  • Headache, dizziness.
  • Frequent urination, dehydration, low blood pressure.
  • Genital fungal infections (mycotic infections), urinary tract infections (UTIs).
  • Sore throat, nasal congestion, runny nose (nasopharyngitis).
  • Mild skin rash or itchy skin, taste changes, difficulty in urination.
  • Hypoglycemia (low blood sugar), especially when used with other anti-diabetic medicines or alcohol, or if meals are delayed or missed. Serious, though rare, side effects can include lactic acidosis. Consult your doctor if side effects persist or worsen.

• Precautions

  • Contraindications: Do not take if you have Type 1 Diabetes Mellitus, severe kidney or liver disease, acute or chronic metabolic acidosis, or an allergy to dapagliflozin or metformin.
  • Pregnancy and Breastfeeding: Generally considered unsafe during pregnancy and not recommended during breastfeeding; consult your doctor.
  • Alcohol Consumption: Avoid excessive alcohol intake, as it may increase the risk of lactic acidosis and hypoglycemia.
  • Medical Conditions: Inform your doctor if you have kidney or liver problems, heart failure, a history of pancreatitis, blood disorders, or if you are taking diuretics. Regular monitoring of kidney function is recommended.
  • Dosage Adjustments: Do not stop taking the medicine abruptly, as it may increase blood sugar levels and the risk of complications.
  • Elderly Patients: Not recommended for individuals aged 85 years or older.

• Storage Store in a cool and dry place, away from direct sunlight. Typically, store at temperatures between 10ºC to 25ºC or below 30ºC. Keep out of sight and reach of children.

What is DAPALEX M 10 MG/500 MG TABLET used for?

DAPALEX M 10 MG/500 MG TABLET is a combination medicine primarily used to treat type 2 diabetes mellitus in adults. It is prescribed when diet and exercise alone are not sufficient to control blood sugar levels. This medication also helps to reduce the risk of hospitalization for heart failure in adults with type 2 diabetes who have established cardiovascular disease or multiple cardiovascular risk factors. Furthermore, it aims to reduce the chances of serious diabetes-related complications such as kidney damage, blindness, nerve problems, heart attacks, or strokes.

How does DAPALEX M 10 MG/500 MG TABLET work?

This medicine contains two active ingredients: dapagliflozin (10mg) and metformin (500mg), which work through different mechanisms to lower blood sugar.

• Dapagliflozin is a sodium-glucose co-transporter 2 (SGLT2) inhibitor. It works by preventing the kidneys from reabsorbing glucose back into the blood, leading to the elimination of excess sugar through urine. Dapagliflozin may also contribute to weight loss and provide cardiovascular benefits.
• Metformin is a biguanide that reduces glucose production in the liver and improves the body's sensitivity to insulin, allowing cells to absorb glucose from the blood more effectively.

What is the usual dosage for DAPALEX M 10 MG/500 MG TABLET?

DAPALEX M 10 MG/500 MG TABLET is usually taken once or twice daily with meals to minimize gastrointestinal side effects. The tablet should be swallowed whole with a glass of water and not crushed, chewed, or broken. Your doctor will determine the appropriate dosage based on your individual needs and response to the medication. It is important to take the medication at the same time(s) each day for consistent blood glucose control.

What are the possible side effects of DAPALEX M 10 MG/500 MG TABLET?

Common side effects may include nausea, vomiting, diarrhea, abdominal pain or discomfort, headache, dizziness, frequent urination, urinary tract infections (UTIs), and genital fungal infections. Other reported side effects include sore throat, nasal congestion, runny nose, flatulence, changes in taste, and back pain. Staying hydrated can help prevent dehydration, which can be a side effect due to increased urination. While rare, serious side effects like lactic acidosis can occur. Hypoglycemia (low blood sugar) may also occur, especially if taken with other diabetes medications or alcohol.

Is DAPALEX M 10 MG/500 MG TABLET safe during pregnancy or breastfeeding?

• Pregnancy: DAPALEX M 10 MG/500 MG TABLET is generally considered unsafe during pregnancy as it may cause harm to the fetus. Dapagliflozin is specifically not recommended during the second or third trimester of pregnancy. Always consult your doctor if you are pregnant or planning to conceive.
• Breastfeeding: This medication is probably unsafe to use during breastfeeding as its components may be excreted into breast milk. It is advised to seek medical advice from your doctor if you are breastfeeding.

Can DAPALEX M 10 MG/500 MG TABLET be taken with other medications?

DAPALEX M 10 MG/500 MG TABLET can interact with several other medications. Inform your doctor about all medicines, supplements, or herbal products you are currently taking.

• Diuretics (e.g., furosemide, hydrochlorothiazide): Concurrent use may increase the risk of dehydration and low blood pressure.
• Insulin and insulin secretagogues (e.g., sulfonylureas like glipizide or glyburide): Combining with these medications can significantly increase the risk of extremely low blood sugar levels (hypoglycemia).
• Iodinated contrast agents: This medicine should not be used if you are undergoing X-rays with certain injectable dyes.
• Cimetidine: Should not be used with this medication.
• Carbonic anhydrase inhibitors (e.g., acetazolamide): May increase the risk of lactic acidosis.
• Cationic medicines (e.g., amiloride, digoxin): These can reduce the elimination of metformin, potentially increasing its levels in the body.

What precautions should be taken while using DAPALEX M 10 MG/500 MG TABLET?

• This medication is not for individuals with type 1 diabetes mellitus or diabetic ketoacidosis.
• Inform your doctor about any history of kidney or liver problems, heart failure, or pancreatitis before starting treatment.
• Regular monitoring of blood sugar levels and kidney function is recommended during treatment.
• Stay well-hydrated by drinking plenty of fluids, as dapagliflozin can increase urination and lead to dehydration.
• Maintain good genital hygiene to help prevent fungal infections, a potential side effect.
• Avoid excessive alcohol consumption, as it can increase the risk of lactic acidosis (a rare but serious side effect) and low blood sugar.
• If you are scheduled for surgery or any medical procedure, notify your doctor that you are taking this medication.
• Exercise caution when driving or operating machinery, as blood sugar levels that are too high or too low can affect your ability.
• Do not stop taking the medicine abruptly without consulting your doctor, as this can cause blood sugar levels to rise and increase the risk of complications.
• It is generally not recommended for individuals aged 85 years or older.

What happens if a dose of DAPALEX M 10 MG/500 MG TABLET is missed?

If you miss a dose of DAPALEX M 10 MG/500 MG TABLET, take it as soon as you remember, unless it is almost time for your next scheduled dose. In that case, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one, as this can increase the risk of side effects.

How should DAPALEX M 10 MG/500 MG TABLET be stored?

DAPALEX M 10 MG/500 MG TABLET should be stored at room temperature, ideally below 30°C or between 10°C to 25°C. Keep it away from moisture and heat, and out of the reach of children.