Macpril 2.5 Mg Tablet (10 Tab)

MACPRIL 2.5 MG TABLET

MACPRIL 2.5 MG TABLET, manufactured by MACLEODS PHARMACEUTICALS LTD., is a medication used to manage various cardiovascular conditions.

• Name:

  • Brand Name: Macpril 2.5 Tablet
  • Common Name: Ramipril 2.5 mg Tablet

• Composition:

  • Active Ingredient: Ramipril (2.5 mg)
  • Macpril 2.5 Tablet belongs to a class of medicines known as Angiotensin-Converting Enzyme (ACE) inhibitors.

• Uses: Macpril 2.5 Tablet is prescribed for:

  • Treating high blood pressure (hypertension).
  • Reducing the risk of heart attack, stroke, and heart failure.
  • Managing heart failure.
  • Slowing the progression of kidney problems, particularly in patients with diabetes.

• Dosage and Administration:

  • Typically, it is taken once daily, with or without food.
  • Swallow the tablet whole with a glass of water; do not chew, crush, or break it.
  • Take the medicine at the same time each day for optimal benefits.
  • The initial adult dose for hypertension and heart failure can be 1.25 mg at bedtime, which may be increased up to 10 mg once daily as prescribed by a doctor. For heart failure after a heart attack, a starting dose of 2.5 mg twice a day might be prescribed.
  • Do not discontinue the medication without consulting a doctor.

• Side Effects:

  • Common Side Effects: Headache, dizziness, fatigue/tiredness, a persistent dry cough, nausea, low blood pressure (hypotension), diarrhea, vomiting, and a mild skin rash.
  • Serious Side Effects: Swelling of the face, lips, throat (angioedema), difficulty swallowing or breathing, severe stomach pain (intestinal angioedema), yellowing of the skin or eyes (liver problems), signs of blood or bone marrow disorders (unusual bruising or bleeding, easy infections, fever), increased potassium levels (hyperkalemia), and a faster heart rate or chest pain. Seek immediate medical attention if these occur.

• Precautions:

  • Pregnancy and Breastfeeding: Not recommended during pregnancy due to potential harm to the unborn baby. It is also generally not recommended during breastfeeding as ramipril can pass into breast milk.
  • Contraindications: Avoid if allergic to ramipril or other ACE inhibitors, or if there's a history of angioedema. Do not take within 36 hours before or after using sacubitril/valsartan. Use with caution or avoid with aliskiren if you have diabetes or kidney problems.
  • Drug Interactions: Inform your doctor about all other medications you are taking, including diuretics, potassium supplements, NSAIDs, other blood pressure-lowering medicines, lithium, and diabetes medications, as interactions can occur.
  • General Warnings: Regular monitoring of blood pressure, electrolyte levels (potassium, sodium), and kidney function is advised. Alcohol consumption should be limited as it can increase dizziness. Caution is needed in patients with liver, heart, or severe kidney problems. Dizziness can occur, especially at the start of treatment or with dose increases; avoid driving or operating machinery if affected. Not recommended for children under 18 years of age.

• Storage:

  • Store in a cool and dry place, below 25°C or 30°C.
  • Protect from light and moisture.
  • Keep out of sight and reach of children.

MACPRIL 2.5 MG TABLET contains Ramipril, an angiotensin-converting enzyme (ACE) inhibitor, which is used to treat high blood pressure and other cardiovascular conditions.

What is MACPRIL 2.5 MG TABLET used for?

MACPRIL 2.5 MG TABLET is primarily used to treat high blood pressure (hypertension). It is also prescribed to reduce the risk of heart attack, stroke, or cardiovascular death in high-risk individuals. Additionally, it can be used to treat heart failure following a heart attack and to reduce or delay the worsening of kidney problems, including in patients with diabetes.

How does MACPRIL 2.5 MG TABLET work?

MACPRIL 2.5 MG TABLET contains Ramipril, which belongs to a class of medicines called ACE inhibitors. It works by blocking the angiotensin-converting enzyme (ACE) in the body. This action prevents the formation of a substance that narrows blood vessels, leading to relaxation and widening of the blood vessels. This, in turn, lowers blood pressure and makes it easier for the heart to pump blood throughout the body.

What is the usual dosage for MACPRIL 2.5 MG TABLET?

For high blood pressure, the usual starting dose is often 2.5 mg once daily. Your doctor will adjust the dose as needed, and it may be increased gradually. For heart failure after a heart attack, an initial dose of 2.5 mg twice per day may be prescribed, with potential increases up to 5 mg twice per day as tolerated. The maximum dose for hypertension is generally not more than 10 mg once daily. It can be taken with or without food.

What are the possible side effects of MACPRIL 2.5 MG TABLET?

Common side effects include a dry, tickly cough that doesn't go away, dizziness (especially when standing up quickly), headaches, nausea, vomiting, diarrhea, and a feeling of weakness or tiredness. More serious, though rare, side effects can include angioedema (severe swelling of the face, lips, tongue, or throat), dangerously low blood pressure, high potassium levels, and signs of liver or kidney problems such as yellowing skin or eyes, or changes in urination. You should contact your doctor immediately if you experience any serious side effects.

Is MACPRIL 2.5 MG TABLET safe during pregnancy or breastfeeding?

MACPRIL 2.5 MG TABLET (Ramipril) is generally not recommended during pregnancy and is contraindicated in the second and third trimesters, as it can cause serious harm or even be fatal to the unborn baby. If you become pregnant while taking this medication, stop taking it and contact your doctor immediately. Its use is also not recommended during breastfeeding, especially when nursing a newborn or preterm infant, as it is unknown how much ramipril passes into breast milk and could potentially affect the baby. Your doctor may suggest alternative treatments.

Can MACPRIL 2.5 MG TABLET be taken with other medications?

Ramipril can interact with several other medications. It is important to inform your doctor about all medications you are taking, including over-the-counter drugs, supplements, and herbal remedies. Key interactions to be aware of include:

• Diuretics (water pills): Can increase the risk of very low blood pressure.
• Potassium supplements or potassium-sparing diuretics: Can lead to increased potassium levels in the blood.
• Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) (e.g., ibuprofen, naproxen): May reduce the effectiveness of Ramipril and potentially affect kidney function.
• Lithium: Ramipril can increase lithium levels in your body.
• Aliskiren: Avoid concurrent use if you have diabetes or kidney problems.
• Angiotensin Receptor Blockers (ARBs) (e.g., valsartan, losartan): Dual blockade of the renin-angiotensin system can increase risks of hypotension, hyperkalemia, and renal impairment.
• Sacubitril/valsartan (Entresto): Do not take Ramipril within 36 hours before or after taking sacubitril/valsartan.

What precautions should be taken?

You should inform your doctor if you have kidney or liver disease, diabetes, or a history of angioedema (swelling). Regular blood tests may be needed to monitor kidney function and potassium levels. Avoid using salt substitutes or potassium supplements unless advised by your doctor. Alcohol consumption should be limited as it can further lower blood pressure and increase side effects like dizziness. If you are scheduled for surgery, including dental surgery, inform your doctor or dentist that you are taking Ramipril, as it may need to be stopped beforehand.

What happens if a dose is missed?

If you miss a dose of MACPRIL 2.5 MG TABLET, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one, as this could lead to dangerously low blood pressure or other toxic side effects.

How should MACPRIL 2.5 MG TABLET be stored?

MACPRIL 2.5 MG TABLET should be stored in a closed container at room temperature, away from moisture, heat, and direct light. It should not be frozen. Keep the bottle tightly closed when not in use.